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For restlessness (Fan Zao) occurring before the eruption of variola (smallpox/variolae), use Xiaodu Yin (Detoxification Decoction) to calm it; for restlessness after eruption, use Liangxue Jiedu Tang (Blood-Cooling and Detoxifying Decoction) to pacify it; if the pustules are flat and clear with scanty fluid accompanied by vexation, treat with Baoyuan Tang (Protect the Origin Decoction); for deficiency-type restlessness after the scabs fall off, use Jiashi Siwu Tang (Modified Four Substances Decoction).

[Note]
In variola cases, tranquility is always auspicious, but the emergence of restlessness inevitably leads to other complications.
"Fan" (vexation/restlessness) refers to mental agitation and indignation; "Zao" (fidgeting/restlessness) refers to physical tossing and turning. These symptoms arise from excessive toxic fire that prevents the Shen (Spirit/Mind) from remaining tranquil.
Restlessness appearing before the eruption indicates exterior constraint; the primary formula is Xiaodu Yin (Detoxification Decoction).
Restlessness appearing after the eruption indicates heat in the blood level; the primary formula is Liangxue Jiedu Tang (Blood-Cooling and Detoxifying Decoction).
If during the stage of pus formation, the pustule tops are flat and the fluid is clear and thin, accompanied by restlessness, this indicates Qi deficiency; the primary formula is Jiawei Baoyuan Tang (Modified Protect-the-Origin Decoction).
Restlessness occurring after the scabs have fallen off (shou ye) indicates Blood deficiency; the primary formula is Jiashan Siwu Tang (Modified Four Substances Decoction).

(Xiaodu Yin / Modified Detoxification Decoction) See the section on Fever among miscellaneous diseases.
(Liangxue Jiedu Tang / Blood-Cooling and Detoxifying Decoction) See the section on Scabbing and Sloughing.
(Jiawei Baoyuan Tang / Modified Protect-the-Origin Decoction) Ren Shen (Ginseng Radix et Rhizoma), Huang Qi (Astragali Radix, processed), Gan Cao (Licorice Radix et Rhizoma, honey-fried), Dang Gui (Angelicae Sinensis Radix, wine-washed), Bai Shao Yao (Paeoniae Radix Alba, stir-baked), Mai Dong (Ophiopogonis Radix, heart removed), Suan Zao Ren (Ziziphi Spinosae Semen, stir-baked and crushed). Decoct in water and take orally.
(Verse Formula)
Jiawei Baoyuan treats deficiency vexation,
Ren Shen, Huang Qi, and Gan Cao gather together;
Wine-washed Dang Gui and stir-baked Bai Shao Yao,
Mai Dong and Suan Zao Ren decocted as one.

(Jiashan Siwu Tang / Modified Four Substances Decoction) Ren Shen (Ginseng Radix et Rhizoma), Dang Gui (Angelicae Sinensis Radix), Mai Men Dong (Ophiopogonis Radix, heart removed), Sheng Di Huang (Rehmanniae Radix), Zhi Zi (Gardeniae Fructus, stir-baked), Bai Shao Yao (Paeoniae Radix Alba, stir-baked). Decoct in water and take orally.
(Verse Formula)
After scabs fall, Blood deficiency often causes restlessness,
Jiashan Siwu Tang is most excellent;
Ren Shen, Dang Gui, and Mai Men Dong,
Sheng Di Huang, Zhi Zi, and Bai Shao Yao prove effective.

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Miscellaneous Diseases in Variola
Delirium (Chan Wang)
When toxic heat blazes and invades the Heart Meridian, it causes confused speech, delirious talking, and unclear spirit; with hallucinations (seeing/hearing things that are not there) and mental confusion, taking Huanglian Jiedu Tang (Coptis Decoction for Resolving Toxins) brings immediate peace.

[Note]
Delirium arises from blazing toxic heat disturbing the Qi of the Heart,
resulting in confused speech, delirious talking, unclear spirit, hallucinations, and mental obtundation. The primary formula is Huanglian Jiedu Tang (Coptis Decoction for Resolving Toxins).
(Huanglian Jiedu Tang / Coptis Decoction for Resolving Toxins) See the section on Scabbing and Sloughing.

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Miscellaneous Diseases in Variola