《病源论》云∶霍乱大吐下，其肠胃俱虚，乃至汗出，其脉欲绝，手足皆冷，名为四逆
者，
《葛氏方》先手足逆冷者方∶灸足内踝上一夫，两足各七壮。
又云∶治下不止手足逆冷方∶椒百枚，附子一枚，水三升，煮取一升，一服。
《医门方》霍乱吐利不止，心烦，四肢逆冷方∶
浓朴 甘草 人参 白术（各二两） 生姜（三两）
以水六升，煮取二升，分二服。
《短剧方》霍乱多寒，手足寒厥，脉绝，茱萸四逆汤主之，方∶
吴茱萸（二升） 当归（三两） 夕药（二两） 桂心（四两） 细辛（二两） 生姜
（半斤） 通草（
凡八物，以水四升，清酒四升，合煮取三升，分四服。
《录验方》∶霍乱吐下而汗出，小便复利，或下利清谷，里外无热，脉微欲绝，或恶寒，
四
人参（三两） 干姜（三两） 附子（二两） 甘草（三两）
凡四物，以水六升，煮取二升半，分三服，转筋肉冷汗出、呕 者良。（《短剧方》同之。）
《葛氏方》治霍乱欲死不能语方∶生姜一斤，切，水七升，煮取二升，分三服。
又方∶饮竹沥少许。
又方∶芦蓬茸大把，浓煮饮二升即瘥。
又方∶干姜（三两） 甘草（一两） 附子（一两）
水三升，煮取一升，分三服。
《病源论》云∶霍乱而欲死者，由饮食不消，冷气内搏，或未得吐利，或虽吐利，冷气
未歇
《极要方》疗霍乱呕而烦闷，胀喘垂死，经日不解方∶
浓朴（四两） 桂心（四两） 枳实（三两） 生姜（十两）
以水八升，煮取三升，分三服。
《葛氏方》治霍乱众治不瘥，烦躁欲死，胀气急方∶烧童女月经衣血末，以酒服少少，
立瘥
又云∶治霍乱神秘起死灸法∶以物横度病患口中，屈之从心鸠尾度以下，灸度下头五壮，
横
又方∶灸脊上，以物围令正心厌。又夹脊左右一寸各七壮，是腹背各灸三处也。
又云∶华佗治霍乱已死，上屋唤魄者，诸治皆至而犹不瘥者方∶捧病患覆卧之，伸臂对，
以
即
又云∶注利不止而转筋入腹欲死方∶生姜三累，拍破，以酒升半，煮三四沸，顿服之。
*The Zhu Bing Yuan Hou Lun* states: In severe cholera with profuse vomiting and diarrhea, the stomach and intestines become deficient. This may lead to sweating, a pulse that is faint and nearly imperceptible, and cold extremities. This condition is referred to as "Si Ni" (Four Coldness / Four Reversals).
*Ge Shi Fang* provides a prescription for cases where cold reversals in the hands and feet appear first: Moxibustion at a distance of one *fu* above the medial malleolus of each foot, seven moxa cones per foot.
It further states: For treating persistent diarrhea and cold reversals in the extremities: One hundred seeds of Zanthoxyli Fructus (Huajiao), one Radix Aconiti Lateralis Preparata (Fuzi), boiled in three sheng of water until one sheng remains; taken once.
*Yi Men Fang* treats cholera with unceasing vomiting and diarrhea, mental restlessness, and cold reversals in the four limbs:
Cortex Magnoliae Officinalis (Houpo), Radix Glycyrrhizae (Gancao), Radix Ginseng (Renshen), Poria Cocos (Baizhu) (each two liang), Rhizoma Zingiberis Recens (Shengjiang) (three liang).
Boil in six sheng of water until two sheng remain; divide into two doses.
*Duan Ju Fang* treats cholera with excessive cold, cold and厥 (jue) extremities, and an imperceptible pulse. It is primarily treated with Zhuyu Si Ni Tang (Evodia Four Coldness Decoction):
Fructus Evodiae (Wuzhuyu) (two sheng), Radix Angelicae Sinensis (Danggui), Radix Paeoniae Alba (Shaoyao) (two liang each), Cortex Cinnamomi (Guixin) (four liang), Radix Asari (Xixin), Rhizoma Zingiberis Recens (Shengjiang) (half jin), Herba Tectariae (Tongcao) (quantity unspecified).
These eight ingredients are boiled together with four sheng of water and four sheng of clear wine until three sheng remain; divide into four doses.
*Lu Yan Fang*: For cholera with vomiting and diarrhea accompanied by sweating, free urination, or diarrhea with undigested food, absence of heat inside and outside, a faint and nearly imperceptible pulse, or aversion to cold, Si Ni Tang (Four Coldness Decoction) is used:
Radix Ginseng (Renshen) (three liang), Rhizoma Zingiberis Secatus (Ganjiang) (three liang), Radix Aconiti Lateralis Preparata (Fuzi) (two liang), Radix Glycyrrhizae (Gancao) (three liang).
These four ingredients are boiled in six sheng of water until two and a half sheng remain; divide into three doses. This is effective if muscle twitching, cold sweat, and vomiting occur. (*Duan Ju Fang* is identical.)
*Ge Shi Fang* treats severe cholera where the patient cannot speak: One jin of Rhizoma Zingiberis Recens (Shengjiang), sliced, boiled in seven sheng of water until two sheng remain; divide into three doses.
Another prescription: Drink a small amount of Bamboo Sap (Zhuli).
Another prescription: Boil a large handful of Reed Catkin (Lupengrong) strongly and drink two sheng; this will cure the condition.
Another prescription: Rhizoma Zingiberis Secatus (Ganjiang) (three liang), Radix Glycyrrhizae (Gancao) (one liang), Radix Aconiti Lateralis Preparata (Fuzi) (one liang).
Boil in three sheng of water until one sheng remains; divide into three doses.
*Zhu Bing Yuan Hou Lun* states: Cholera leading to a critical state occurs because undigested food combines with internal cold qi. The patient may not yet have vomited or had diarrhea, or even if they have, the cold qi has not subsided.
*Ji Yao Fang* treats cholera with vomiting, mental distress, abdominal distension, panting, approaching death, and no relief after a day:
Cortex Magnoliae Officinalis (Houpo) (four liang), Cortex Cinnamomi (Guixin) (four liang), Fructus Aurantii Immaturus (Zhishi), Rhizoma Zingiberis Recens (Shengjiang) (ten liang).
Boil in eight sheng of water until three sheng remain; divide into three doses.
*Ge Shi Fang* treats cholera refractory to various treatments, characterized by extreme irritability, approaching death, and urgent abdominal distension: Burn the menstrual cloth of an unmarried girl to ash, take a small amount with wine; immediate recovery ensues.
It also states: A mysterious moxibustion method for reviving those near death from cholera: Measure horizontally across the patient's mouth, bend the measuring object, and extend it from the heart center (Jiuwei CV15) downwards. Moxa five cones at the lower end of this measurement... [text incomplete].
Another prescription: Moxibustion on the spine, aligning the measuring object centrally over the heart. Also, moxa seven cones on each side, one cun lateral to the spine. This constitutes three points on the abdomen and back.
It also states: Hua Tuo's method for reviving those who have died from cholera, involving calling the soul from the roof, for cases where all other treatments fail: Place the patient prone, extend arms opposite each other... [text incomplete].
Another prescription: For unceasing diarrhea with spasms moving into the abdomen and approaching death: Three units of Rhizoma Zingiberis Recens (Shengjiang), crushed, boiled in half a sheng of wine for three to four boils; taken in one dose.