漏芦 升麻 大黄 蓝叶 黄芩 玄参等分 芒硝（甚者加至二钱）
疫疠积热，时生疙瘩结毒，俗称流注，面肿咽塞者，此方主之。
经曰∶营气不从，逆于肉理，乃生毒痈；又曰∶热胜则肿，故疫疠之余热，解之未尽，
逆留于分肉之间，则作上件诸证。药之为性，辛能解散，苦能胜热，漏芦、升麻、蓝叶，辛
而且苦，故足以解结热；咸能软坚，苦能泻实，大黄味苦，芒硝味咸，故足以软坚而泻实；
玄参苦而润，黄芩苦而枯，润者去血中之热，而枯者去气中之热尔，况与漏芦、升麻走散之
药同用之，则又无所不至矣。
大黄（酒浸） 牡蛎（炙） 僵蚕（等分）
疫毒内郁，时成疙瘩者，此方主之。
《内经》曰∶陷脉为 ，留连肉腠。谓阳毒乘脉之虚而陷入之，便壅结而为 核，留连
于肉腠之间，正此疫毒疙瘩之谓也。苦能下热，故用大黄；咸能软坚，故用僵蚕、牡蛎。
凡觉天行时气，恐其相染，须日饮雄黄酒一卮，仍以雄黄豆许用绵裹之，塞鼻一窍，男
左女右用之。或用大蒜塞鼻，或用阿魏塞鼻皆良。
雄黄气悍，能辟恶邪；大蒜、阿魏，气之至臭者，臭胜则诸秽皆不足以加之矣。但蒜大
热，阿魏透脑，虚人难用，不若雄黄便于事尔。
叙曰∶大头瘟，前古未之论也，东垣始论之。
今上壬午，北方病此者甚众，死者不啻数万人。昆居南土，未尝见其证。乡人自北来者
，皆言患者头大如斗，跻头而还自若也。今考三方，观其大略。
Rhizoma Euphorbiae Humifusae (Loulu), Rhizoma Cimicifugae (Shengma), Radix et Rhizoma Rhei (Dahuang), Folium Isatidis (Lanye), Radix Scutellariae (Huangqin), Radix Scrophulariae (Xuanshen) in equal parts; Natrii Sulfas (Mangxiao) (increase to 2 qian for severe cases).
This formula is indicated for epidemic pestilence with accumulated heat, manifesting as nodules and toxic swellings, commonly known as Liuzhu (flowing abscesses), characterized by facial swelling and pharyngeal obstruction.
The *Neijing* states: "When Ying Qi (Nutritive Qi) does not flow smoothly and reverses into the muscle tissue, toxic carbuncles arise"; it also states: "Excessive heat leads to swelling." Therefore, residual heat from an epidemic, if not fully resolved, may reverse and remain between the muscles (Fenrou), causing the aforementioned symptoms. The nature of herbs is such that Pungent flavors can disperse, and Bitter flavors can overcome heat. Loulu, Shengma, and Lanye are both pungent and bitter, thus sufficient to resolve knotting heat; Salty flavors can soften hardness, and Bitter flavors can purge excess. Dahuang is bitter, and Mangxiao is salty, thus sufficient to soften hardness and purge excess; Xuanshen is bitter and moistening, while Huangqin is bitter and drying. Moistening herbs remove heat from the blood, while drying herbs remove heat from the Qi. Moreover, when used together with dispersing herbs like Loulu and Shengma, their therapeutic effects reach everywhere.
Radix et Rhizoma Rhei (Dahuang) (soaked in wine), Concha Ostreae (Muli) (calcined), Bombyx Batryticatus (Jiangcan) in equal parts.
This formula is indicated for internal stagnation of epidemic toxins, manifesting as nodules.
The *Neijing* states: "When pathogens sink into the vessels, they become scrofula (Luo Li), lingering in the muscle interstices." This refers to Yang toxins taking advantage of vessel deficiency to sink in, causing congestion and knotting into nodular masses, lingering in the muscle interstices, which precisely describes epidemic toxin nodules. Bitter flavors can descend and clear heat, hence Dahuang is used; Salty flavors can soften hardness, hence Jiangcan and Muli are used.
Whenever one feels exposed to seasonal epidemic Qi and fears infection, one should drink a cup of Xionghuang Wine daily. Additionally, take a piece of Xionghuang (Asinum Corneum / Realgar) the size of a soybean, wrap it in cotton, and insert it into one nostril (left for males, right for females). Alternatively, using Garlic or Asafetida (Awei) inserted into the nose is also effective.
Xionghuang has a potent aroma capable of repelling evil pathogens; Garlic and Awei have extremely foul odors; overpowering foulness prevents all turbid evils from invading. However, Garlic is excessively hot, and Awei's odor penetrates the brain, making them difficult to use for deficient individuals, whereas Xionghuang is more convenient for practical application.
Preface: Da Tou Wen (Big Head Plague) was not discussed in ancient texts; Li Dongyuan was the first to discuss it.
In the Renwu year of this reign, many in the North suffered from this disease, with deaths exceeding tens of thousands. I reside in the South and have never witnessed these symptoms. Those coming from the North report that patients' heads swelled as large as a bushel basket, yet they walked with their heads remaining steady and balanced. Here, I examine these three formulas to observe their general principles.