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Those who appear healthy but have the Five Elements (Wu Xing, the five phases of material transformation) severed will die. Those who appear healthy but undergo a change in temperament will die. Those who appear healthy but suddenly speak deliriously will die. Those who appear healthy but suddenly become mute will die. Those who appear healthy but develop panting/asthma will die. Those who appear healthy but develop Qiangzhong (priapism/pathological erection) will die. Those who appear healthy but suddenly go blind will die. Those who appear healthy but suddenly develop swelling and fullness will die. Those who appear healthy but suffer from constipation will die. Those who appear healthy but suddenly lose their pulse will die. Those who appear healthy but suddenly fall into a coma resembling drunkenness will die. This is because both internal and external vital energies are exhausted. If the condition is contrary (Ni), death occurs immediately; if it follows the natural order (Shun), survival for two years is possible, yet ultimately none survive.

When a patient should feel cold but instead feels hot, or should feel hot but instead feels cold; when they should vomit but do not, or should have diarrhea but do not; when they should sweat but do not, or should speak but do not; when they should sleep but do not, or should drink water but do not—all these belong to Zai Guai (abnormal/ominous symptoms). These arise because the Qi of the Five Zang Organs fails to follow one another harmoniously. The appearance of Si Ni (Four Reversals/Cold Extremities) indicates an untreatable condition. Si Ni refers to the mismatch between Host Qi and Guest Qi, where neither conforms to the appropriate seasonal timing.

Diseases originating in the Six Fu Organs belong to the Yang system. Their onset may manifest upwards or downwards, internally or externally, or even centrally, representing the extreme of Qi movement. Patients may exhibit singing and laughing, weeping and mourning, running about, groaning, curling up in submission, or acting with arrogant self-importance. Some may sleep without waking. If a patient desires water, provide water to nourish them; if they desire ice, provide ice to assist them. Do not forcibly contradict the patient's preferences, nor forcibly suppress them. By following and accommodating their wishes, ten out of ten can be saved, a hundred out of a hundred can be saved, and no disease will remain incurable.

Diseases originating in the Five Zang Organs belong to the Yin system. Their onset may present as Pian Ku (hemiplegia), Wei Jue (flaccidity and cold extremities), exterior cold with interior heat, or exterior heat with interior cold. It may cause abdominal distension and fullness, spasms and curling of the hands and feet, deviation of the mouth and eyes, numbness of the skin, difficulty walking, or rigidity of the body. It may lead to incessant vomiting and diarrhea, or indicate that Yang Qi is inevitably deficient. Conversely, if Yang Qi is excessive, Yin Qi must be insufficient. As stated previously: "If Yang is deficient, aid it with Fire Essence; if Yin is deficient, nourish it with Water Mother." This is the principle. Therefore, if the patient desires sweating, induce sweating; if they desire warmth, apply warmth; if they desire heat, apply heat; if they desire fire therapy, apply fire therapy; if they desire decoctions, administer decoctions. Sweating, warming, heating, fire therapy, and decoctions are all applied according to what is appropriate. The way of treatment and rescue lies herein.