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Bone Extreme primarily pertains to Kidney disease. The Kidney corresponds to the bones, and the bones harmonize with the Kidneys. If wind pathogen is encountered in winter causing Bone Bi (Bone Obstruction Syndrome), and if this condition persists without resolution while further pathogens are contracted, the pathogen may internally lodge within the Kidneys. This results in severe deficiency pain, which constitutes the manifestation of Bone Extreme. When the Qi of the Foot-Shaoyin meridian ceases, the bones become withered. The Shaoyin meridian is the pulse channel of the Kidney; it travels deep within and warms the bone marrow. If the bone marrow fails to receive warmth, the muscles will detach from the bones, and death may occur within a day.

To treat Bone Extreme, characterized by heat in the head, pain in the limbs and joints, inability to sleep or lie down comfortably, and accompanied by loss of appetite, Sheng Gan Di Huang San (Raw Dried Rehmannia Powder) is indicated.
Ingredients: Sheng Gan Di Huang (Raw Dried Rehmanniae Radix, 1 liang), Bai Fu Ling (Poria, 1 liang), Dang Gui (Angelicae Sinensis Radix, 1 liang), Mai Men Dong (Ophiopogonis Radix, 1 liang, heart removed), Ren Shen (Ginseng Radix, 1 liang, radix tip removed), Che Qian Zi (Plantaginis Semen, 1 liang, stir-fried until slightly reddish).
Preparation: Crush and sieve the above ingredients into a powder. For each dose, take 4 qian, decoct with one zhong zhan (approx. 200-300ml) of water until reduced to 6 fen (approx. 120-180ml), filter out the dregs, and take warm at any time.

To treat Bone Extreme due to Kidney deficiency, presenting with soreness and pain in the feet, knees, and bone marrow, Suan Zao Ren San (Ziziphus Jujube Seed Powder) is indicated.
Ingredients: Suan Zao Ren (Ziziphi Spinosae Semen, 8 liang, lightly stir-fried), Hu Jing Gu (Tigriis Ossis, 8 liang, coated with butter and roasted until yellow), Shu Gan Di Huang (Prepared Dried Rehmanniae Radix, 8 liang), Du Zhong (Eucommiae Cortex, 3 liang, coarse bark removed, roasted until yellow).
Preparation: Finely chop the ingredients. Soak in 1 dou 5 sheng (approx. 1.5 liters) of clear wine for three days, then sun-dry. Repeat soaking and drying until the wine is exhausted. Grind into a fine powder through a silk sieve. Take 2 qian before meals, mixed with warm wine.

To treat Bone Extreme, aiming to strengthen the bones and marrow and promote robust health, Di Huang Jian (Rehmannia Decoction/Paste) is indicated.
Ingredients: Sheng Di Huang Zhi (Fresh Rehmanniae Radix Juice, 3 sheng), Fang Feng (Saposhnikoviae Radix, 2 liang, radix tip removed), Huang Qi (Astragali Radix, 2 liang, sliced), Lu Jiao Jiao (Cervi Cornu Colla, 2 liang, crushed and stir-fried until dry and yellow), Dang Gui (Angelicae Sinensis Radix, 1 liang).
Preparation: Grind the solid ingredients into a fine powder. First, decoct the fresh Rehmannia juice until reduced by one sheng. Add the powder and marrow to the juice, stir well, and simmer over low heat until it reaches a paste-like consistency.

To treat Bone Extreme, characterized by soreness and pain in the limbs and joints, weakness in the calves, and tinnitus due to deficiency, Fu Zi Wan (Aconite Pill) is indicated.
Ingredients: Fu Zi (Aconiti Lateralis Radix Praeparata, 2 liang, split, skin and umbilicus removed), Rou Cong Rong (Cistanches Herba, 2 liang, soaked in wine overnight, scraped clean, and dried), Bu Gu Zhi (Psoraleae Fructus, 1 liang, lightly stir-fried), Lu Rong (Cervi Cornu Pantotrichum, 1 liang, hair removed, roasted until yellow), Niu Xi (Achyranthis Bidentatae Radix, 1 liang, sprouts removed), Tu Si Zi (Cuscutae Semen, 1 liang, soaked in wine for three days, dried).
Preparation: Grind into powder, mix with refined honey, and pound 300-200 times. Form into pills the size of Sophora seeds. Take 3 pills with warm wine on an empty stomach and before evening meals.

To treat Bone Extreme, characterized by emaciation, weak Kidneys, weakness in the waist and legs, vexing pain in the joints, Lu Jiao Jiao Wan (Deer Antler Glue Pill) is indicated.
Ingredients: Lu Jiao Jiao (Cervi Cornu Colla, 2 liang, crushed and stir-fried until dry and yellow), Bu Gu Zhi (Psoraleae Fructus, 1 liang, lightly stir-fried), Shi Hu (Dendrobii Caulis, 1 liang, roots removed and sliced), Shu Gan Di Huang (Prepared Dried Rehmanniae Radix, 1 liang), Shan Yao (Dioscoreae Rhizoma, 1 liang, separately pounded into powder), Suan Zao Ren (Ziziphi Spinosae Semen, 1 liang, lightly stir-fried), Rou Cong Rong (Cistanches Herba, 1 liang, soaked in wine, scraped, and roasted).
Preparation: Grind into powder, mix with refined honey, and pound 500-300 times. Form into pills the size of Sophora seeds. Take 30 pills with warm wine on an empty stomach and before evening meals.

To treat Bone Extreme due to Kidney labor injury, presenting with shortness of breath, insufficiency of Qi, emaciation, weakness, joint soreness, frequent pain in the waist and legs, and inability to stand for long periods, a formula to fill the bone marrow is indicated.
Ingredients: Sheng Di Huang (Fresh Rehmanniae Radix, 8 jin, washed, dried, crushed, and juiced), Da Ma Ren (Cannabis Fructus, half jin, ground in water and juiced), Niu Sui (Bovine Marrow, 1 jin), Bai Mi (White Honey, 2 jin).
Preparation: Simmer the base mixture in a silver pot. Additionally, prepare Suan Zao Ren (Ziziphi Spinosae Semen, 2 liang, roasted and husked), Bu Gu Zhi (Psoraleae Fructus, 2 liang, roasted until yellow and sliced), Tu Si Zi (Cuscutae Semen, 2 liang, soaked in wine for three days and dried). Grind these additional herbs into powder, add to the Rehmannia decoction, and simmer over low heat. When suitable for pill formation, shape into pills the size of quail eggs. Take by dissolving in warm wine.

To treat Bone Extreme, characterized by emaciation, mental restlessness due to deficiency heat, pain in the feet and knees, and inability to stand for long, Shu Gan Di Huang Wan (Prepared Rehmannia Pill) is indicated.
Ingredients: Shu Gan Di Huang (Prepared Dried Rehmanniae Radix, 2 liang), Bai Fu Ling (Poria, 1 liang), Niu Xi (Achyranthis Bidentatae Radix, 1 liang, sprouts removed), Ling Yang Jiao Xie (Saiga Tataricae Cornu, 3 fen), Suan Zao Ren (Ziziphi Spinosae Semen, 1 liang, lightly stir-fried), Bai Zi Ren (Platycladi Semen, 1 liang), Shi Hu (Dendrobii Caulis, 1 liang, roots removed and sliced).
Preparation: Grind into powder, mix with refined honey, and pound 300-200 times. Form into pills the size of Sophora seeds. Take 30 pills with warm wine on an empty stomach and before evening meals daily.

To treat Bone Extreme, characterized by soreness and pain in the knees and calves, and multiple joint pains, Hu Jing Gu Jiu (Tiger Tibia Wine) is indicated.
Ingredients: Hu Jing Gu (Tigriis Ossis, one pair, coated with butter and roasted until yellow).
Preparation: Crush the bone. Brew wine using rice koji according to standard methods. After twenty days when the wine is ready, take one zhong zhan (approx. 200-300ml), warm it, and consume on an empty stomach and before evening meals.

To treat Bone Extreme with excess heat, characterized by soreness and pain in the bone marrow, Sheng Di Huang Jian (Fresh Rehmannia Paste) is indicated.
Ingredients: Sheng Di Huang Zhi (Fresh Rehmanniae Radix Juice, 3 sheng), Sheng Tian Men Dong Zhi (Fresh Asparagi Radix Juice, 1 sheng), Bai Mi (White Honey, half jin).
Preparation: Mix evenly and simmer over low heat until it becomes a paste. Take half a spoonful after meals, mixed with decoction of Bamboo Leaves (Zhu Ye Tang).