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In epidemic febrile diseases (Epidemic Febrile Disease) caused by damp-heat, cases with polyuria are rare. After the pathogen transmits inward, polyuria may occasionally occur; this is due to the stomach earth transforming into dryness-heat, and urgent purgation should be employed. If polyuria persists after repeated purgations, it indicates Qi deficiency, and treatment should focus on tonifying Qi and raising Yang. There are also cases of polyuria due to Kidney deficiency, treated with Liuwei Dihuang Tang (Six-Ingredient Rehmannia Decoction) added with Wuweizi (Schisandrae Fructus). Generally, before purgation, polyuria belongs to dryness-heat syndrome; the urine must be slightly yellow, accompanied by vexatious heat, thirst, and a desire to drink. After purgation, polyuria belongs to deficiency syndromes. In Qi deficiency, there is no desire to drink, and the Cun pulse is weaker than the Chi pulse, with the superficial pulse being weaker than the deep pulse; in Yin deficiency, there is a desire to drink, and the Chi pulse is weaker than the Cun pulse, with the deep pulse being weaker than the superficial pulse. If untreated for a long time, it may transform into Xiao Ke (Wasting-Thirst Syndrome). This describes polyuria in epidemic febrile diseases. As for polyuria caused by wind-cold, it belongs to Yang deficiency and is not included in this discussion.

Polyuria occurring at the initial stage of epidemic febrile disease mostly belongs to San Yang He Bing (Combined Disease of the Three Yang Channels). When the pathogen enters the Yang channels, Yang becomes excess and Yin becomes deficient. Heat is intense on the exterior, causing the interior to lose its control. Additionally, with mental confusion in the upper jiao, the patient is unaware of the discharge from the lower orifices, resulting in enuresis. If this condition is combined with abdominal fullness, body heaviness, inability to taste properly, dirty facial complexion, and delirium, Zhang Zhongjing advocates using Baihu Tang (White Tiger Decoction) exclusively. This condition should not be treated with purgation because the pathogen is fully abundant in the exterior and meridians; purging would cause the exterior pathogen to sink inward, leading to slight sweating on the forehead and cold extremities. It is especially inadvisable to use diaphoresis (sweating method), as the pathogen is inherently heat; sweating would increase the heat, causing mental restlessness and worsening delirium. One should only use Baihu Tang to clear the floating and overflowing heat. If additionally complicated by dryness accumulation and pain, Dahuang (Rhei Radix et Rhizoma) can be added to the base decoction for purgation.

Scrotal retraction (Nuo Suo) in epidemic febrile disease results from heat entering the Jueyin channel. If there is both accumulation and heat, purgation is used; if there is heat without accumulation, clearing heat is used. Once the heat subsides, the scrotum naturally relaxes. Scrotal retraction in Yin syndromes is quite similar to that in epidemic febrile diseases, as both present with cold body, cold extremities, and a deep pulse. However, one is cold and the other is hot, so they differ. In Yin syndrome scrotal retraction, the penis shrinks or completely retracts into the abdomen, resembling a woman's anatomy; in epidemic heat-jue scrotal retraction, the penis remains normal in shape. Differentiation can further be made through accompanying symptoms: in Yin syndrome scrotal retraction, urination is clear, the lower abdomen pulls and hurts but is not full, prefers warmth and pressure, often accompanied by spontaneous diarrhea, with clear consciousness and no vexation; in epidemic scrotal retraction, urination is red, the lower abdomen is full, hard, painful, and rejects pressure, stool is constipated, and the patient is vexed with confused consciousness.