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Injuries caused by tigers, dogs, snakes, scorpions, centipedes, leeches, and similar creatures all fall into this category. There are twenty-three formulas in total, all recorded in the ancient texts from entry 326 to entry 258.

The poison of Gu (a mythical venomous creature or toxin) is rarely seen in the Central Plains. It is said that people in the deep mountains of Guangdong and Guangxi place three animals—venomous snakes, centipedes, and toads—in the same vessel on the Dragon Boat Festival, allowing them to devour each other until only one survives. This survivor is considered Gu, also known as "Tiao Sheng" (picking life). When used to harm others, Gu is secretly placed in food or drink. Once ingested, the victim suffers severe abdominal pain as if being gnawed by insects, with vomit and excrement resembling rotting cotton. If not treated immediately, the poison consumes the five zang organs, leading to death within ten days or more. In slower cases, it may take months, causing extreme depletion of qi and blood before the victim dies after the five zang organs are consumed.

Another theory states that in the valleys of Guangdong and Guangxi, there is a herb called Human Cao (Hu Man Grass), also known as Duanchang Cao (Intestine-Severing Grass). If swallowed with fast-flowing water, death occurs rapidly; if swallowed with slow-flowing water, death occurs slowly. Currently, in the Jingchu region, there is a plant called Shumang Cao (Rat Poison Grass); ingestion leads to fatal poisoning, which is believed to be the same as Human Cao.

Yet another account describes how people in Lingnan kill venomous snakes, cover them with grass, and sprinkle them with water. After several days, mushrooms grow. These mushrooms are ground into powder, mixed with wine, and used to poison victims. Initially, there are no symptoms, but later, drinking alcohol triggers the poison, leading to death. In local customs, promiscuous women often have illicit relations with men from the north. After a long time, they develop affection but refuse to drive the men away. Instead, they secretly poison their food. When the northern man leaves, he is warned: "When will you return?" If he returns as promised, an antidote is administered. If he fails to return on time, he dies. This is called "Nian Nian Gu" (Year-Determining Gu). Northerners visiting these regions should take precautions, carrying antidotes such as Jiedu Dan (Detoxification Pill) at all times. Whenever one feels discomfort in the four elements (earth, water, fire, wind) after eating, an antidote should be taken immediately. Without prior knowledge and preparation, emergency rescue may be impossible. As the saying goes, "Preparedness ensures security." Those who value life must not neglect this.

"Dun Zhai Xian Lan" states: The fish from Hainan includes the Stone-Head Fish, whose bone forms the "fish pillow." Vessels made from this bone can hold food and drink. If exposed to Gu poison, the vessel will crackle and burst, demonstrating its efficacy. Fujian artisans craft these vessels exquisitely, yet most people merely admire their appearance without understanding their function.

1. Method to test for Gu: Spit saliva into clear water. If it sinks, it indicates Gu; if it floats, it does not.

Another method: Hold a soybean in the mouth. If poisoned by Gu, the bean swells and its skin peels off. If not poisoned, the bean remains unchanged.

Another method: Boil one egg, remove the shell, insert a pair of silver hairpins into it, and swallow it whole. After a moment, retrieve and inspect. If both the hairpins and the egg turn black, it confirms Gu poisoning.

Sun Simiao stated: Anyone who chews raw black beans without a fishy smell, or holds alum in the mouth finding it sweet rather than bitter, has been poisoned by Gu.