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Huangdi asked: What about diseases arising from Yin? Qibo replied: Worry and overthinking damage the Heart; double cold (external exposure to cold pathogens combined with internal consumption of cold food/drink) damages the Lungs; anger damages the Liver; sexual intercourse while drunk, with sweat exposed to wind, damages the Spleen; excessive physical exertion, or sexual intercourse followed by sweating, damages the Kidneys. These are the diseases occurring in the three regions of interior and exterior. Huangdi asked: How should they be treated? Qibo replied: Observe the site of pain to determine the corresponding organ, distinguish between excess and deficiency, tonify when appropriate, reduce when appropriate, do not go against the timing of nature; this is called supreme treatment.

This passage summarizes the meaning of the preceding text. The previous text mentioned that excessive eating, irregular lifestyle, and internal injury due to worry and anger are all diseases arising from Yin. Here, the causes of injury are detailed to differentiate damage among the five Zang organs. "Double cold" refers to external contraction of cold pathogens and internal injury from cold food and drink. External contraction involves differences in wind, rain, cold, and heat; internal injury involves distinctions in diet and seven emotions. The five Zang and six Fu organs, as well as the depth of meridians, must all be distinguished. In summary, these fall within the scope of diseases arising from the three regions of interior and exterior. Treatment must first examine the cause and the nature of the pain, as mentioned above, to understand the correspondence between interior and exterior, and the location of accumulations. Then, differentiate between deficiency/excess and cold/heat to apply tonification or reduction methods. By conforming to the seasonal changes of cold, heat, warmth, and coolness, and the order of Yin-Yang ascension and descent, one harmonizes Qi and Blood, unblocks meridians, and harmonizes the Zang-Fu organs; this is called the most excellent treatment.

In *Ling Shu: Wu Bian Pian*, Huangdi asked: How can we predict who is prone to intestinal accumulations? Shaoyu replied: If the skin is thin and lacks luster, and the muscles are not firm but soft and moist, such individuals have poor gastrointestinal function. Poor function allows pathogenic factors to remain and accumulate, causing harm. Between the Spleen and Stomach, if cold and warmth are disordered, even slight pathogenic invasion leads to retention and accumulation, resulting in large masses.

Thin skin lacking luster indicates Lung Qi deficiency; muscles that are not firm but soft and moist ("nao ze," meaning soft like mud) indicate Spleen Qi deficiency. The Intestines and Stomach are the Fu organs of the Lungs and Spleen. When the Zang organs are deficient, the Fu organs inevitably become dysfunctional, allowing turbid pathogenic factors to stagnate and accumulate, thereby causing harm. If there is a disorder of cold and warmth between the Spleen and Stomach, even slight exposure to pathogens will combine with existing retained accumulations, leading to stagnation and eventually forming large pathological masses.