（素问五常政大论）
帝曰∶有毒无毒，服有约乎？（约，度也。禁服篇曰∶夫约方者，犹约囊也，囊满而弗约则输泄，方成有药则神与
弗俱。）岐伯曰∶病有久新，方有大小，有毒无毒，固宜常制矣。（病重者宜大，病轻者有小，无毒者宜多，有毒者宜少，
皆常制之约也。）大毒治病，十去其六，常毒治病，十去其七，小毒治病，十去其八，无毒治病，十去其九。（药性有大
毒、常毒、小毒、无毒之分，去病有六分、七分、八分、九分之约者，盖以治病之法，药不及病，则无济于事，药过于
病，则反伤其正而生他患矣。故当知约制，而进止有度也。王氏曰∶大毒之性烈，其为伤也多。小毒之性和，其为伤也
少。常毒之性，减大毒之性一等，加小毒之性一等，所伤可知也。故至约必止之，以待来证尔。然无毒之药，性虽平和，
久而多之，则气有偏胜，必有偏绝，久攻之则脏气偏弱，既弱且困，不可长也，故十去其九而止。）谷肉果菜，食养尽之，
无使过之，伤其正也。（病已去其八九而有余未尽者，则当以谷肉果菜饮食之类培养正气而余邪自尽矣。如藏气法时论曰，
毒药攻邪，五谷为养，五果为助，五畜为益，五菜为充者是也。然毒药虽有约制，而饮食亦贵得宜，皆不可使之太过，
过则反伤其正也。）不尽，行复如法。（如此而犹有未尽，则再行前法以渐除之，宁从乎慎也。）必先岁气，无伐天和。（五
运有纪，六气有序，四时有令，阴阳有节，皆岁气也。人气应之以生长收藏，即天和也。设不知岁气变迁而妄呼寒热，
则邪正盛衰无所辨，未免于犯岁气、伐天和矣，夭柱之由，此其为甚。又治其王气义，详本类前七。）无盛盛，无虚虚，
而遗人夭殃。（邪气实者复助之，盛其盛矣。正气夺者复攻之，虚其虚矣。不知虚实，妄施攻补，以致盛者愈盛，虚者愈
虚，真气日消，则病气日甚，遗人夭殃，医之咎也。）无致邪，无失正，绝人长命。（盛其盛，是致邪也。虚其虚，是失
正也。重言之者，所以深戒夫伐天和而绝人长命，以见岁气不可不慎也。）
The Yellow Emperor asked: Regarding the use of toxic and non-toxic medicines, is there a limit to their administration? ("Yue" refers to a limit. The *Jin Fu Pian* states: To constrain a prescription is like binding a bag; if the bag is full but not bound, it will leak. If a prescription is compounded with herbs but not constrained, the spirit and medicinal power cannot work together.) Qibo replied: Diseases vary in duration (new vs. chronic), and prescriptions vary in size. Whether the medicines are toxic or non-toxic, they should always adhere to standard regulations. (Severe diseases require larger prescriptions, while mild diseases require smaller ones; non-toxic medicines can be used in larger doses, while toxic medicines should be used in smaller doses. These are all standard limits.) When using highly toxic medicines to treat disease, stop when six-tenths of the disease is eliminated; when using moderately toxic medicines, stop when seven-tenths is eliminated; when using slightly toxic medicines, stop when eight-tenths is eliminated; and when using non-toxic medicines, stop when nine-tenths is eliminated. (Medicines are classified into highly toxic, moderately toxic, slightly toxic, and non-toxic categories. The limits for eliminating disease are six, seven, eight, and nine-tenths respectively. This is because the method of treatment dictates that if the medicinal strength does not reach the pathogen, it is ineffective; if it exceeds the pathogen, it damages healthy Qi and causes other complications. Therefore, one must understand the principle of restraint and regulate the administration and cessation of medicine. Wang Bing said: The nature of highly toxic medicines is fierce, causing much harm. The nature of slightly toxic medicines is mild, causing little harm. The nature of moderately toxic medicines is one degree less than highly toxic and one degree more than slightly toxic, so the extent of harm can be inferred. Thus, one must stop at the prescribed limit to await further conditions. However, although non-toxic medicines have a mild nature, long-term and excessive use leads to an imbalance of Qi, resulting in deficiency. Long-term attack weakens Zang-Fu Qi; once weak and exhausted, it cannot be sustained. Hence, one stops when nine-tenths of the disease is eliminated.) Use dietary nourishment from grains, meats, fruits, and vegetables to completely eliminate the remaining pathogens, ensuring no excess occurs that might damage healthy Qi. (When the pathogenic factor has been reduced by eight or nine-tenths but some remains, one should cultivate healthy Qi through diet such as grains, meats, fruits, and vegetables, allowing the residual pathogens to clear naturally. As stated in the *Zang Qi Fa Shi Lun*: Toxic medicines attack pathogens; five grains provide nourishment; five fruits assist; five animals benefit; five vegetables fill. Although toxic medicines have constraints, diet must also be appropriate. Excess in either case damages healthy Qi.) If the disease is not fully resolved, repeat the previous methods. (If there is still residue after following the above, repeat the prior methods to gradually eliminate it, preferring caution.) One must first consider the annual climate (Sui Qi) and not violate the harmony of Heaven (Tian He). (The Five Movements have order, the Six Qi have sequence, the Four Seasons have commands, and Yin and Yang have rhythm; these constitute Sui Qi. Human Qi responds to Sui Qi through growth, flourishing, harvesting, and storage, which is Tian He. If one ignores changes in Sui Qi and arbitrarily uses cold or heat therapies, the balance between pathogenic and healthy Qi cannot be distinguished, inevitably violating Sui Qi and damaging Tian He, leading to premature death. For details on treating dominant Qi, see Part Seven of this category earlier.) Do not reinforce excess (Sheng Sheng) and do not deplete deficiency (Xu Xu), thereby avoiding causing premature death to patients. (Reinforcing a patient with excess pathogenic factors makes the excess greater; attacking a patient with deficient healthy Qi makes the deficiency worse. Ignoring deficiency and excess and blindly applying tonification or purgation results in excess becoming more excessive and deficiency becoming more deficient. Healthy Qi diminishes daily, while pathogenic Qi intensifies, leaving patients vulnerable to premature death. This is the fault of the physician.) Do not invite pathogens and do not lose healthy Qi, thus preserving human longevity. (Making excess more excessive invites pathogens. Making deficiency more depleted loses healthy Qi. Repeating this emphasizes the warning against violating Tian He and cutting short human life, highlighting the necessity of caution regarding Sui Qi.)