Drinking decoctions in place of water is most effective, or Nie's Qingjie San (a formula from Nie Jiuwu's *Doumen Fangzhi*) is also excellent. Once the smallpox eruptions have fully appeared and are filled with pus, it is appropriate to employ methods to invigorate blood and clear toxins. One may酌情 (discretionarily) choose between Nie's Qingdu Huoxue Tang (from *Doumen Fangzhi*) and Wu's Liangxue Jiedu Tang (from Ye Tianshi's *Youke Yaolüe*). If adverse syndromes occur with multiple cases of sinking/retraction: for purple sinking, use Qingdu Huoxue Tang as the main prescription, heavily augmented with Rhinoceros Horn (Xi Jiao) and pig tail blood; for black sinking, use Fei's Bisheng Tang (from Fei Jianzhong's *Jiu Pian Suo...