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The disease of the Yangming channel (Er Yang, referring to the Stomach and Large Intestine) often originates from dysfunction of the Heart and Spleen. Patients may experience difficulties in expressing hidden or delicate matters (Bu De Yin Qu), and women may suffer from amenorrhea (Bu Yue). [Note: Er Yang refers to the Yangming channel. The Stomach belongs to Earth, and the Heart belongs to Fire; Fire generates Earth, hence they are in a mother-son relationship. Excessive emotional desires can internally damage essence and externally injure the form, both leading to stomach pathology. This is why diseases of Er Yang originate from the Heart and Spleen. "Bu De Yin Qu" indicates the decline of Yang energy; "Bu Yue" means menstruation does not flow down. "Yin Qu" refers to concealed or difficult-to-express matters, or bowing the head (Yin) and bending the body (Qu).] If the condition transmits (Chuan) over time and develops into "Feng Xiao" (Wind Wasting, characterized by emaciation due to Liver Wood overacting on Spleen Earth) or "Xi Ben" (Panting/Rebellious Qi, where Lung Qi is obstructed by Fire pathogen causing rapid breathing), it is considered a fatal and incurable syndrome. [Note: "Chuan" refers to transmission over time. "Feng" relates to Wind-Wood qi. "Xiao" means withering and emaciation. When Liver Wood attacks Spleen Earth, muscles waste away, named "Feng Xiao". When the Lung is affected by Fire, Qi movement is hindered and becomes rebellious, named "Xi Ben". This results from deficiency of Essence in the lower Jiao affecting all five Zang organs, representing an untreatable state.]

Disease of the Taiyang channel (San Yang, referring to the Bladder and Small Intestine) manifests as alternating chills and fever, abscesses or swellings in the lower body, as well as flaccidity syndromes (Wei) and cold extremities (Jue). [Note: San Yang refers to the Taiyang channel. The Bladder governs Water transformation, and the Small Intestine governs Fire transformation; thus, pathology presents with chills and fever. Fire pathogens cause ulceration and abscesses, while Water pathogens cause coagulation and swelling, leading to lower-body abscesses or swellings. Excess Heat leads to Wei (flaccidity), excess Cold leads to Jue (cold extremities). Conflict between Cold and Heat causes sour pain (Yuan).] If transmitted, it may develop into "Suo Ze" (loss of luster/dryness due to fluid depletion) or "Tui Shan" (scrofula/hernia involving testicular swelling). [Note: The Bladder and Small Intestine govern fluids; depletion leads to loss of luster. Regarding "Suo Ze", Wu's annotation suggests "Suo Gao" (retracting testicles); "Tui Shan" refers to non-painful testicular swelling. Pain indicates Fire/Small Intestine involvement, while non-pain indicates Water/Bladder involvement.]

Disease of the Shaoyang channel (Yi Yang, referring to the Triple Burner and Gallbladder) manifests as shortness of breath (Shao Qi), frequent coughing, and diarrhea. [Note: Yi Yang refers to the Shaoyang channel. Both the Triple Burner and Gallbladder contain Ministerial Fire. Vigorous Fire consumes Qi and damages the Lung, causing shortness of breath and coughing. The Large Intestine (Dry Metal) is constrained by Fire, leading to diarrhea.] If transmitted, it may develop into "Xin Che" (pulling sensation in the Heart) or "Ge" (diaphragmatic obstruction). [Note: The Heart is Monarch Fire; when Ministerial Fire flares upward, similar energies attract, and pathogens enter the Heart, causing palpitations with a pulling sensation, named "Xin Che". Fire accumulation internally obstructs the Upper Jiao and Lower Wan, causing blockage in the middle, named "Ge".]

Simultaneous disease of the Yangming channel (Er Yang, Stomach/Large Intestine) and Jueyin channel (Yi Yin, Liver/Heart) primarily manifests as fright and terror (Jing Hai), back pain, belching (Yi), and yawning (Qian). This condition is named "Feng Jue" (Wind Jue). [Note: Yi Yin refers to the Liver and Heart. The Heart governs Fire, and the Liver governs Wind; Wind and Fire battling cause fright. Back pain occurs because the meridians of Hand and Foot Yangming run along the spine. Belching and yawning are signs of rebellious Wind and Fire, hence the name "Feng Jue". Note: Wu's annotation reads "Yi Yin Fa Bing" alone.]

Simultaneous disease of the Shaoyin channel (Er Yin, Heart/Kidney) and Shaoyang channel (Yi Yang, Triple Burner/Gallbladder) manifests as distension, chest fullness, and frequent sighing. [Note: Er Yin refers to the Heart and Kidney; their simultaneous disease prevents the interaction of Water and Fire. Disease of the Triple Burner prevents the circulation of Qi up and down, resulting in distension and sighing (Qi rebellion).]

Simultaneous disease of the Taiyang channel (San Yang, Small Intestine/Bladder) and Taiyin channel (San Yin, Spleen/Lung) manifests as hemiplegia (Pian Ku), flaccidity with functional alteration (Wei Yi), and inability to move the four limbs. [Note: San Yang refers to the Small Intestine and Bladder; San Yin refers to the Spleen and Lung. The Small Intestine meridian governs fluids; the Bladder meridian governs sinews; the Spleen governs the four limbs; the Lung governs Qi. Pathology in these four meridians leads to these symptoms. "Wei Yi" refers to flaccidity accompanied by abnormal changes in form or function.]