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Yi Tangchen of Baofeng County, who had just undergone the capping ceremony (coming of age), usually preferred cold food and drink in his daily diet. Over time, this developed into a Yin syndrome (a syndrome characterized by deficiency-cold). His pulse was slow and intermittent, occurring once after seven or eight beats, and later reduced to only three beats per cycle. I urgently administered several doses of warming and hot agents. After four or five days without resolution, I continued with one dose at midnight, three doses during the day and one at night, which gradually revived the pulse. One night, the medication was accidentally omitted; the next morning, the symptoms worsened significantly. Subsequently, I consecutively administered the previous medicine for seven days, both day and night. The patient recovered through profuse sweating. When asked about the reason, I said: "Humans share the same Qi as Heaven and Earth. Yang syndromes typically worsen during the day and improve at night, while Yin syndromes worsen at night and improve during the day; each transforms according to its own category. Now, the disease is at its Yin extreme and worsens particularly at night, hence the medication is given at midnight. Why? This is to repel the Yin that transforms according to its kind and to connect with the Yang born after the Zi hour (11 PM - 1 AM), so that Yin easily retreats and Yang easily generates." This principle is fully detailed in the previous chapter.

The mother of Qin Er from the bathhouse on the north side of Yijing Street in Luzhou suffered from Taiyin syndrome (a syndrome involving the Spleen and Stomach characterized by internal cold) for three days without relief. Later, she experienced vomiting, regurgitation, and nausea, but her pulse was not floating. Wen Zhi and I administered Banliu Wan (Half-Sulfur Pill) two or three times, but it did not stop the symptoms. We then administered Huangqi Jianzhong Decoction (Astragalus and Middle-Jianzhong Decoction). The pulse became extremely tight, lacking distinct exterior or interior signs, with intense heat in the chest and thirst prompting drinking. Everyone suspected a Yang syndrome and wanted to give her water. I argued with Wen Zhi against this. A day later, we administered drugs such as Shengjiang (Fresh Ginger) and Fuzi (Prepared Aconite Root). The tight pulse instead became fine and deep, and Yang had not yet generated. We used Jiuwan (Wine Pills) made from Guizhi (Cinnamon Twig), Fuzi (Prepared Aconite Root), Shengjiang (Fresh Ginger), and Wutou (Monkshood Root), taking 100 pills at a time. In two days, more than ten doses were taken. Thirst stopped, but the pulse remained fine and deep. Because the patient's body was hot, dry, restless, and anxious to sweat, but could not tolerate heat interference, her clothes and covers were removed. However, her true Yang qi circulation was incomplete, and upon exposure to wind and cold, sweat could not emerge. Her spirit was confused and unconscious. Her family dressed her heavily, waiting for her death. Since she could still swallow, I continued administering the previous pills. Only when the Yang pulse appeared did she break out in profuse sweating. This was likely due to her long-term preference for Sansheng Tea (Three-Life Tea), causing accumulated cold. After recovery, her blocked urination and defecation finally became smooth. The next day, she passed a basin full of dark blood resembling pig liver. However, Wen Zhi remained doubtful and unable to judge. I taught him to use Weifeng Tang (Stomach-Wind Decoction) added with Guizhi (Cinnamon Twig) and Fuzi (Prepared Aconite Root). After three doses, the bleeding stopped. Such severe cold is unprecedented in the world; treatment requires careful deliberation. Generally, differences in symptom changes before and after are best distinguished by the pulse, which is most accurate, without relying solely on external symptoms.