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For any sores that are severely ulcerated and difficult to heal, use Dongtian Jiuku Dan (see formulas for painful toxins). Take three qian per dose, administered with aged wine. After taking the medicine, cover with a blanket to induce sweating; this can lead to recovery.

Another method: Detoxification method (see formulas for carbuncles and ulcers). Apply continuously for several days until the sore gradually flattens and heals. Alternatively, use Xama San (see below) applied fully over the sore opening, which is also effective. Or use Yuhong Gao (see below), which is also effective.

Additionally, for cases where the sore opening is hard and painful mentioned previously, refer to various other formulas.

Refer to various formulas for recurrence after healing of sores mentioned later. For all toxic sores that fail to heal for a long time, there must be worms inside; treating according to the various formulas below will surely result in a cure. If it still does not heal, there must be fine bones inside the sore; treat according to the formulas for Duogu Ju (multiple bone abscess) mentioned below. If hundreds of medicines prove ineffective, it is likely due to evil influence; smoke with white dry dog feces, or if toxic fluid flows out or other substances are discharged, it will heal naturally.

Duan Shi Shui (Calcined Stone Water): Place one jin (approx. 500g) of whole calcined stone in a basin. Pour eight jin of boiling clear water into the basin. Wait for the calcined stone to dissolve, stir evenly with a stick. Once the water clarifies, gently pour the liquid into another container (discarding the residue). Filter the liquid through fine cloth, collect the clarified liquid, and store in a bottle for use. This is applicable for toxic sores that have failed to heal for a long time.

Di Long Shui (Earthworm Water): Use white-necked earthworms (also known as Di Long, or Qu Chan), quantity unspecified. Place them in a porcelain bowl, add a handful of white rock sugar, and cover tightly. After one or two days, they will liquefy into clear water. Apply a small amount into the sore; the wound will close within several days.

Another formula: One centipede, roasted dry and ground into powder. Mix with sesame oil and apply topically. The sore will close within several days, and pain relief is miraculous.

Another formula: Turtle shell, roasted on a tile until carbonized but retaining its medicinal properties, then ground into fine powder. Sprinkle onto the sore; it promotes closure and tissue regeneration with supreme efficacy.

Another formula: Cut open a crucian carp and remove the entrails. Fill the fish belly with roasted dry sheep manure. Roast the stuffed fish on a tile until carbonized, then grind into powder. Apply the dry powder to the sore; the wound will close naturally. A person suffering from a back carbuncle with a deep, large sore that could not heal was cured using this method.

Another formula: Longan aril (longan flesh is better). Masticate using the saliva of the opposite sex (men use women's saliva, women use men's saliva; ensure the mouth is rinsed clean first). Ensure it melts completely, then fill the sore opening.

Another formula: One branch of Angelica sinensis (Danggui). Fry in sesame oil until charred, then grind into fine powder. Mix with pure raw sesame oil and pack into the sore. The wound will gradually grow and heal, with miraculous pain-relieving effects.

Another formula: Chinese gallnut (Wubeizi), roasted dry and ground into powder. Mix well with good vinegar, spread on cloth, and apply as a patch. Cover with a layer of paper pasted with fine cloth to prevent air exposure; this yields miraculous results.

Another formula: Lead carbonate (Qianfen). Sprinkle onto the sore for immediate healing. A person had a sore on the ear with dripping pus and blood for years without healing. Using this formula resulted in closure within three days.

Additionally, all methods for promoting tissue regeneration and closing sores found in the formulas for carbuncles and toxins are extremely effective. Among them, Shuixian Gao, Xama San, and Wugong Gao have particularly miraculous effects. Additionally, the Baiyou Gao for the legs is also highly effective.

Additionally, regarding hard and painful sore openings (see above) and recurrence after healing (see below, refer to all relevant formulas).