疫论已见首卷，分来路两条，去路三条，治法五条，详且尽矣。大法，天行之气，从经
络入，其证头痛发热，宜微散，香苏散散之。病气传染，从口鼻入，其证呕恶胸满，宜解秽
神术散和之。若两路之邪，归并于里，腹胀满闷，谵语发狂，唇焦口渴者，治疫清凉散清
之。便闭不通者，加大黄下之。其清凉散内，人中黄一味，乃退热之要药，解秽之灵丹，医
家缺而不备，安能取效？复有虚人患疫，或病患变虚，或妄治变虚者，须用人参、白术、当
归等药，加入清凉药内，以扶助正气。如或病气渐退，正气大虚，更宜补益正气为主。夫发
散、解秽、清中、攻下四法外而以补法驾驭其间，此收效万全之策也。予尝用麦冬、生地各
一两，加人参二三钱，以救津液。又尝用人参汤，送下加味枳术丸，以治虚人郁热便闭之症
病气退而元气安，遂恃为囊中活法，谨告同志，各自存神。又有头面肿大，名曰大头瘟者
颈项粗肿，名曰虾蟆瘟者，古方普济消毒饮并主之。但头肿之极，须用针砭，若医者不究
其理，患者畏而不行，多致溃裂腐烂而难救。若颈肿之极，须用橘红、淡盐汤吐去其痰，再
用前方倍甘桔主之，须宜早治，不可忽也。
香苏散 （见太阳证。
神术散 （见类中。
秦艽 赤芍 知母 贝母 连翘（各一钱） 荷叶（七分） 丹参（五钱） 柴胡（一钱五分） 人中黄
水煎服。
如伤食胸满，加麦芽，山楂、萝卜子、陈皮；胁下痞，加鳖甲，枳壳；昏愦，谵语，加
黄连。热甚大渴，能消水者，加石膏、天花粉、人参。便闭不通，腹中胀痛者，加大黄下之
。虚人自汗多，倍加人参。津液枯少，更加麦冬，生地。若时行寒疫，不可轻用凉药，宜斟
普济消毒饮、针砭法 （并见头痛。
加味枳术丸 （见腹痛。
制人中黄法 用竹筒两头留节，刮去青皮，开一孔，将甘草装满，仍用木屑塞口，融松
香封固，用绳扎定，于腊月初一日，投厕缸中，一月足，取起，用水濯洗，然后劈开竹筒，
将甘草晒干，收藏听用。
或问∶香苏散、神术散，芳香药也，人中黄，有秽气者也，而皆以之解疫毒，消秽气，
何也？不知邪客上焦，乃清虚之所，故用芳香以解之。邪客中、下二焦，乃浊阴之所，疫毒
至此，结而为秽，则非芳香所能解，必须以秽攻秽而秽气始除，此人中黄之用，所以切当也
夫病有先后，有部位，有更改，而用药随之，方为活法。医家常须识此，不只治疫一端而
疫病理论已在首卷中论述，分为来路两条、去路三条、治法五条，详尽且完备。
基本法则：天行疫气从经络侵入，症状表现为头痛发热，适宜轻微发散，用香苏散来疏散它。病气通过口鼻传染侵入，症状表现为呕吐恶心、胸膈满闷，适宜化解秽浊，用神术散调和它。如果来自两路的邪气归并到体内深处，出现腹部胀满闷痛、胡言乱语甚至发狂、嘴唇焦裂口渴等症状，用治疫清凉散来清解它。如果大便闭塞不通，加入大黄攻下它。在清凉散中，人中黄这一味药，是退热的关键药物，化解秽浊的灵丹妙药，如果医生缺少而不准备，怎么能取得疗效呢？又有体质虚弱的人患瘟疫，或者病人病情转变为虚证，或者因误治导致变为虚证的，必须用人参、白术、当归等药物，加入到清凉药中，以扶助正气。如果病气逐渐消退，但正气极度虚弱，更应当以补益正气为主。在发散、解秽、清中、攻下这四种方法之外，再辅以补法驾驭其中，这是万无一全的收效策略。我曾经用麦冬、生地各一两，加入人参二三钱，来救治津液亏损。又曾经用人参汤，送服加味枳术丸，来治疗体质虚弱者郁热导致的大便闭塞症状。病气退去而元气安定，我便将其视为囊中的活法，郑重地告诉志同道合的医者，各自用心体悟保存。还有头面部肿大，称为大头瘟的；颈部粗肿，称为虾蟆瘟的，古方普济消毒饮都主治这些病症。但是头部肿胀到了极点，必须用针砭疗法（刺破皮肤放血或排脓），如果医生不探究其原理，患者害怕而不施行，多会导致溃烂破裂腐烂而难以救治。如果颈部肿胀到了极点，必须用橘红、淡盐水催吐以去除痰涎，然后再用前方加倍桔梗和甘草来主治，适宜尽早治疗，不可疏忽大意。
治疫清凉散组成：秦艽、赤芍、知母、贝母、连翘（各一钱），荷叶（七分），丹参（五钱），柴胡（一钱五分），人中黄。水煎服。
如果因伤食导致胸膈满闷，加麦芽、山楂、萝卜子、陈皮；胁下有痞块，加鳖甲、枳壳；神志昏沉糊涂、胡言乱语，加黄连。热势极盛且大渴，能大量饮水者，加石膏、天花粉、人参。大便闭塞不通，腹部胀痛者，加大黄攻下它。体质虚弱者自汗多，加倍加入人参。津液枯少，更加入麦冬、生地。如果是时行的寒性瘟疫，不可轻易使用凉药，适宜斟酌使用普济消毒饮。
制人中黄的方法：用竹筒两头保留节段，刮去青皮，开一个孔，将甘草装满，仍用木屑塞住口，融化松香封固，用绳子扎紧，在腊月初一日，投入厕所缸中，一个月期满，取出，用水洗涤干净，然后劈开竹筒，将甘草晒干，收藏备用。
有人问：香苏散、神术散是芳香类药物，人中黄是有秽臭气味之物，却都用它们来解除疫毒、消除秽气，为什么呢？不知道邪气客居上焦，那是清虚的地方，所以用芳香药来解除它。邪气客居中焦、下焦，那是浊阴的地方，疫毒到达这里，凝结成为秽浊，那么就不是芳香药所能解除的，必须以秽攻秽，秽气才能清除，这就是人中黄的作用，所以非常恰当。疾病有先后顺序，有部位差异，有变化更改，用药随之调整，这才是灵活的方法。医生经常需要认识这一点，不只是治疗瘟疫这一方面而已。
The theory of epidemic diseases has been discussed in the first volume, divided into two routes of origin, three routes of progression, and five treatment methods, which is detailed and comprehensive.
General principles: The qi of heavenly epidemics enters through the meridians and collaterals; the symptoms include headache and fever, suitable for mild dispersal, using Xiangsu San (Perilla and Cyperus Powder) to disperse it. Pathogenic qi transmitted via contagion enters through the mouth and nose; the symptoms include vomiting, nausea, and chest fullness, suitable for resolving turbidity, using Shenzhu San (Atractylodes Powder) to harmonize it. If the pathogenic factors from both routes merge into the interior, resulting in abdominal distension and fullness, delirium, mania, cracked lips, and thirst, use Zhiyi Qingliang San (Epidemic-Cooling Clearing Decoction) to clear them. If there is constipation with inability to pass stool, add Dahuang (Rhubarb Root) to purge them. Among the ingredients of Qingliang San, Renzhonghuang (Human Manure Processed with Bamboo) is a crucial herb for reducing fever and a miraculous elixir for resolving turbidity. If physicians lack or do not prepare this ingredient, how can they expect efficacy? Furthermore, for individuals with deficiency constitution contracting an epidemic, or for patients whose condition transforms into deficiency due to the disease itself, or due to improper treatment leading to deficiency, herbs such as Renshen (Ginseng Root), Baizhu (Atractylodes Macrocephala Rhizome), and Danggui (Angelica Sinensis Root) must be added to the clearing medicines to support the righteous qi. If the pathogenic qi gradually recedes but the righteous qi is severely deficient, the primary approach should be tonifying the righteous qi. Beyond the four methods of dispersing, resolving turbidity, clearing the middle, and purging downward, employing the method of tonification to manage these situations is a strategy that ensures complete efficacy. I have once used Maidong (Ophiopogon Tuber) and Shengdi (Rehmannia Root) each in amounts of one liang, adding 2-3 qian of Renshen (Ginseng Root) to rescue fluid depletion. I have also used Renshen Tang (Ginseng Decoction) to administer Jiawei Zhizhu Wan (Modified Atractylodes and Immature Bitter Orange Pill) to treat conditions of deficiency constitution with stagnant heat and constipation. With the pathogenic qi receding and the primal qi stabilized, I regard this as a flexible method kept in my sleeve. I earnestly advise my colleagues to internalize this. Additionally, for cases of massive swelling of the head and face, termed Datou Wen (Big Head Plague), and coarse swelling of the neck, termed Xia Wa Wen (Toad Plague), the ancient formula Puji Xiaodu Yin (Universal Benefit Detoxification Decoction) is indicated for both. However, if the head swelling is extreme, needle pricking (Bian Fa) is required. If physicians do not investigate the rationale, or if patients fear the procedure and refuse it, it often leads to ulceration, rupture, putrefaction, and untreatable outcomes. If the neck swelling is extreme, Chuhong (Tangerine Peel) and light salt water should be used to induce vomiting to expel phlegm, followed by the aforementioned formula with doubled Jiegeng (Platycodon Root) and Gancao (Licorice Root). Early treatment is essential; do not neglect this.
Xiangsu San (See Taiyang Syndrome section)
Shenzhu San (See Stroke-like Syndromes section)
Zhiyi Qingliang San Composition: Qinjiao (Gentiana Macrophylla Root), Chishao (Red Peony Root), Zhimu (Anemarrhena Rhizome), Beimu (Fritillaria Bulb), Lianqiao (Forsythia Fruit) (each 1 qian), Heye (Lotus Leaf) (0.7 qian), Danshen (Salvia Miltiorrhiza Root) (5 qian), Chaihu (Bupleurum Root) (1.5 qian), Renzhonghuang (Human Manure Processed with Bamboo). Decoct in water and take orally.
If chest fullness is caused by food stagnation, add Maiya (Barley Sprout), Shanzha (Hawthorn Fruit), Luobozhi (Radish Seed), and Chenpi (Aged Tangerine Peel); if there is hypochondriac mass, add Biejia (Turtle Shell) and Zhike (Immature Bitter Orange); if there is mental confusion and delirium, add Huanglian (Coptis Rhizome). If heat is severe with great thirst and ability to consume large amounts of water, add Shigao (Gypsum Fibrosum), Tianhuafen (Trichosanthes Root), and Renshen (Ginseng Root). If there is constipation with abdominal pain and distension, add Dahuang (Rhubarb Root) to purge. For deficient individuals with spontaneous sweating, double the amount of Renshen (Ginseng Root). For depleted fluids, add more Maidong (Ophiopogon Tuber) and Shengdi (Rehmannia Root). If it is a seasonal cold epidemic, cool medicines should not be used lightly; instead, carefully consider using Puji Xiaodu Yin (Universal Benefit Detoxification Decoction).
Bian Fa (Needle Pricking Therapy) (See Headache section)
Jiawei Zhizhu Wan (Modified Atractylodes and Immature Bitter Orange Pill) (See Abdominal Pain section)
Method for Preparing Renzhonghuang (Human Manure Processed with Bamboo): Take a bamboo tube, leaving nodes at both ends. Scrape off the green skin, make a hole, and pack it full of Gancao (Licorice Root). Plug the hole with wood shavings, seal it with melted rosin, and tie it securely with rope. On the first day of the twelfth lunar month, submerge it in a latrine tank. After one month, retrieve it, wash it with water, split open the bamboo tube, dry the Gancao (Licorice Root), and store it for use.
Question: Xiangsu San (Perilla and Cyperus Powder) and Shenzhu San (Atractylodes Powder) are aromatic herbs, while Renzhonghuang (Human Manure Processed with Bamboo) has a foul odor. Why are all of them used to resolve epidemic toxins and eliminate turbidity? Answer: It is unknown that when pathogens lodge in the Upper Jiao (Upper Burner), which is a clear and empty region, aromatic herbs are used to resolve them. When pathogens lodge in the Middle and Lower Jiao (Middle and Lower Burners), which are regions of turbid yin, epidemic toxins condense into filth there. In such cases, aromatic herbs alone cannot resolve the issue; one must use filth to attack filth for the turbidity to be cleared. This is why the use of Renzhonghuang (Human Manure Processed with Bamboo) is so appropriate. Diseases have sequences, locations, and transformations, and medications must follow accordingly to constitute flexible methods. Physicians must constantly recognize this, not only in the context of treating epidemics.