《皇甫谧救解法》云∶春发逆冷，夏发短气，秋发瘙痒，冬发寒战。
此四时发动，变易无常。诸所为病，乃至万端。或动身体，四肢微强，难于屈伸，或胸
胁胀满。但欲干呕，或翕翕少气，不欲语言，或睡眠但常欲卧，或KT KT 苦寒，思欲浓
衣，诸如此候，药将大发。宜急解，事在汗出、动作、饮酒、美食以为法。
或头痛目不欲视，或腹中雷鸣大小便数，或体隐疹状如风搔，或淫策淫策如针刺，或有
热剧乍来乍去，或咽喉噎塞有如伤寒，或鼻中萧条若有风吹。诸如此者，皆是将发之候。宜
速起行解衣向风便自解。
或苦寒噤战如伤寒者，当饮热酒随人能，不先以暖汤小洗头面手足，行步自动作使体中
热，以手巾渍冷水摩拭之，良。
或腹中雷如鸣，饮冷水一升，若饥，可餐食薄衣脱巾胃毡褥。
或但苦热闷而腹满心痛者，宜饮热酒，冷水洗，还薄衣小暖，热气自止。
或患腹背热，如手如杯如盘许者，以冷石随热处熨即瘥。
或头痛项强两目疼而闷乱者，便以水洗浴即瘥。
《薛曜论》云∶夫金石之性坚刚，而急烈，又性清净而滓恶秽。
皇甫谧云∶凡诸石士十忌∶
第一忌 怒 第二忌愁忧 第三忌哭泣 第四忌忍大小便 第五忌忍饥 第六忌忍渴
第七忌忍热 第八忌忍寒 第九忌忍过用力 第十忌安坐不动
若犯前件忌，药势不行，偏有聚结，常自安稳，调和四体，亦不得苦读念虑。但能如是，
终不发动，一切即愈。
曹歙论云∶凡药疾（ ）禁忌者，第一不宜悲思哭泣，其次不甚宜出筋力已自劳役，不
宜触盛日猛（大），不宜甚嗔恚忧恐，不宜热衣热食，不宜服热药针灸，不宜食饼，黍羹羊
酪皆含热，故悉不宜食之。
《庞氏论》云∶诸服草木石散者，皆不可灸针身体令人善发炎疽疮也。
《皇甫谧救解法》中说：春季服用石药发作表现为四肢逆冷，夏季发作表现为气短，秋季发作表现为皮肤瘙痒，冬季发作表现为寒战。
这四季的发作，变化无常。由此引发的各种病症，甚至多达万种。有的导致身体活动异常，四肢轻微僵硬，难以屈伸；有的出现胸胁部胀满感。有的只想干呕，有的气息微弱，不想说话；有的睡眠时总是想躺着不动；有的感到寒冷刺骨，想要穿厚衣服；诸如此类的症状，说明药毒即将大发。应当紧急解除药毒，方法在于出汗、运动、饮酒、食用美味食物。
有的出现头痛、眼睛不适不愿视物；有的腹中肠鸣如雷，大小便频繁；有的身体出现隐疹，状如风邪搔抓所致；有的感觉像针刺一样疼痛；有的高热剧烈，忽来忽去；有的咽喉阻塞，感觉如同伤寒病；有的鼻腔干燥，好像有风吹入。诸如此类情况，都是药毒即将发作的征兆。应当迅速起身行走，解开衣襟面向微风，药毒自然就会解除。
如果苦于寒冷颤抖，如同伤寒病患者一样，应当饮用热酒，根据个人的承受能力适量饮用。如果不先以温水稍微清洗头面手足，通过步行等活动使身体发热，然后用浸过冷水的手巾擦拭身体，效果很好。
如果腹中雷鸣般作响，可以饮用一升冷水。如果感到饥饿，可以吃些清淡的食物，脱去头巾和厚重的衣物，盖在胃部的毡褥也要适当减少。
如果只是苦于燥热烦闷且腹部胀满、心痛，应当饮用热酒，用冷水清洗身体，然后穿着薄衣保持微微温暖，热气自然会停止。
如果患腹部和背部发热，热度如同手捧杯盘大小的范围，可以用冷石头在发热的部位熨烫，随即痊愈。
如果出现头痛、颈项强直、两眼疼痛且心烦意乱的情况，用水洗浴即可痊愈。
《薛曜论》说：金石药物的性质坚硬刚烈，又具有清净但杂质污秽的特性。
皇甫谧说：凡是服用石药的人有十大禁忌：
第一忌愤怒 第二忌忧愁 第三忌哭泣 第四忌憋忍大小便 第五忌忍受饥饿 第六忌忍受口渴
第七忌忍受炎热 第八忌忍受寒冷 第九忌过度用力 第十忌久坐不动
如果触犯上述禁忌，药势无法运行，容易偏聚结滞。只要平时保持安稳，调和四肢，也不得刻苦读书或思虑过度。只要能做到这些，最终就不会发作，一切病症都会痊愈。
曹歙论述说：凡是患有服药引起的疾病（石药病）的禁忌事项，第一不宜悲伤思念哭泣，其次不宜过度使用筋骨力量进行劳役，不宜接触盛夏猛烈的阳光，不宜大怒嗔恚或忧恐，不宜穿热衣吃热食，不宜服用热性药物或进行针灸，不宜吃饼类食物，黍米羹、羊酪都含有热性，所以都不宜食用。
《庞氏论》说：凡是服用草木石散的人，都不可对身体进行艾灸和针刺，否则容易引发炎症、疽疮等皮肤病。
The "Huangfu Mi Rescue Method" states: In spring, the manifestation of stone drug toxicity involves cold extremities; in summer, it manifests as shortness of breath; in autumn, as skin itching; and in winter, as chills.
These seasonal manifestations change unpredictably. The diseases caused by them can number in the thousands. Some cause physical abnormalities, with slight stiffness in the four limbs making flexion and extension difficult; some present with distension and fullness in the chest and hypochondrium. Some have an urge to dry heave; some have weak qi and do not wish to speak; some sleep but constantly desire to lie down; some suffer from intense cold, desiring thick clothing. For such symptoms, indicating that the drug toxicity is about to erupt severely, urgent detoxification is required. The methods include inducing sweating, physical activity, drinking alcohol, and consuming delicious food.
Some present with headache and eyes that are uncomfortable and unwilling to look at things; some have borborygmus (abdominal rumbling) like thunder, with frequent urination and defecation; some have hidden rashes on the body resembling wind-induced scratching; some feel pain like needle pricks; some experience severe fever that comes and goes suddenly; some have throat obstruction feeling similar to Taiyang disease (a syndrome characterized by exterior pathogenic invasion); some have nasal dryness as if wind is blowing into them. All such conditions are signs that the drug toxicity is about to manifest. One should quickly rise and walk, loosen clothing, and face the breeze, so the toxicity will resolve naturally.
If suffering from intense cold and trembling, resembling a patient with Taiyang disease, one should drink warm wine according to one's tolerance. It is beneficial to first wash the head, face, hands, and feet slightly with warm water, engage in walking or other activities to generate heat in the body, and then wipe the body with a towel soaked in cold water.
If there is borborygmus like thunder in the abdomen, drink one sheng (approx. 200ml) of cold water. If hungry, one may eat light food, remove head coverings and heavy garments, and reduce the felt blankets covering the stomach area.
If suffering merely from hot oppression and stuffiness with abdominal fullness and heart pain, one should drink warm wine, wash with cold water, wear thin clothes to maintain slight warmth, and the heat will stop naturally.
If suffering from heat in the abdomen and back, localized to an area the size of a hand holding a cup or plate, apply cold stones to the heated areas for moxibustion-like warming (here implying cooling compress via cold stone), and recovery will follow immediately.
If presenting with headache, stiff neck, painful eyes, and mental restlessness, bathing with water will lead to recovery.
The "Xue Yao Discourse" states: The nature of metal and stone drugs is hard, rigid, and fierce, yet they possess properties of purity mixed with impure dregs.
Huangfu Mi said: There are ten taboos for those taking stone drugs:
First taboo: Anger Second taboo: Sorrow/Worry Third taboo: Crying Fourth taboo: Holding back urination and defecation Fifth taboo: Enduring hunger Sixth taboo: Enduring thirst
Seventh taboo: Enduring heat Eighth taboo: Enduring cold Ninth taboo: Overexertion Tenth taboo: Sitting still without movement
If these taboos are violated, the drug's action will not circulate properly, leading to accumulation and knotting. As long as one remains calm, harmonizes the four limbs, and avoids intense reading or excessive mental exertion, one can ensure the toxicity does not erupt, and all ailments will heal.
Cao She discussed: Regarding the taboos for drug-induced illnesses (Stone Drug Disease): First, one should not engage in sad thoughts or crying; second, one should not overexert muscles and sinews through labor; third, one should not expose oneself to the fierce midday sun; fourth, one should not become extremely angry, resentful, worried, or fearful; fifth, one should not wear hot clothes or eat hot foods; sixth, one should not take hot-natured medicines or undergo acupuncture; seventh, one should not eat cakes/biscuits; eighth, millet porridge and sheep cheese contain heat properties, so one should not consume them.
The "Pang Shi Discourse" states: Those who take herbal or mineral powders must not undergo moxibustion or acupuncture on their bodies, as this easily leads to inflammation, carbuncles, and sores.