强中病者，茎长兴盛不痿，精液自出是也。由少服五石，五石热住于肾中，下焦虚热，
少壮之时，血气尚丰，能制于五石，及至年衰，血气减少，肾虚不复能制精液。若精液竭，
则诸病生矣。
夫散脉，或洪实；或断绝不足，欲似死脉；或细数；或弦快坐所犯非一故也。脉无
常投，医不能识。热多则弦快，有癖则洪实，急痛则断绝。凡寒食药率如是。无苦，非
死候也。勤从节度，不从节度则死矣。
欲服散，宜诊脉候；审正其候，尔乃毕愈。脉沉数者，难发；难发当数下之。脉浮大者
，易发也。人有服散两三剂不发者，此人脉沉难发，发不令人觉，药势行已，药但于内发，
不出形于外。欲候知其得力，人进食多，是一候；气下，颜色和悦，是二候；头面身痒瘙，
是三候；策策恶风，是四候；厌厌欲寐，是五候也。诸有此证候者，皆药内发五脏，不形出
于外，但如方法服散，勿疑。但数下之，则内虚，当自发也。
诸方互有不同∶皇甫唯欲将冷，廪丘公欲得将暖之意。其多有情致也。世人未能得其深
趣，故鲜能用之。然其方法，犹多不尽，但论服药之始，将息之度，不言发动之后。治解之
宜，多有阙略。江左有道弘道人，深识法体，凡所救疗，妙验若神，制《解散对治方》，云
∶
钟乳对术，又对栝蒌，其治主肺，上通头胸。术动钟乳，胸塞短气；钟乳动术，头痛目
疼。又，钟乳虽不对海蛤，海蛤动乳则目痛短气。有时术动钟乳，直头痛胸塞。然钟乳与术
所可为患，不过此也。虽所患不同，其治亦一矣。发动之始，要其有由，始觉体中有异，与
上患相应，便速服葱白豉汤。
又云∶硫黄对防风，又对细辛，其治主脾肾，通腰脚。防风、细辛动硫黄，烦疼腰痛，
或忿无常，或下利不禁。防风、细辛能动硫黄，硫黄不能动彼。始觉发，便服杜仲汤。
白石英对附子，其治主胃，通至脾肾。附子动白石英，烦满腹胀；白石英动附子，则呕
逆不得食，或口噤不开，或言语难，手脚疼痛。觉发，服生麦门冬汤。
紫石英对人参，其治主心肝，通至腰脚。人参动紫石英，心急而痛，或惊悸不得眠卧；
或恍惚忘误，失性狂发；或黯黯欲眠，或愦愦喜 ，或瘥或剧，乍寒乍热；或耳聋目暗。又
，防风虽不对紫石，而能动紫石，紫石由防风而动人参。人参动，亦心痛烦热，头项强。始
觉，便宜服麻黄汤。
赤石脂对桔梗，其治主心，通至胸背。桔梗动赤石，心痛口噤，手足逆冷，心中烦闷；
赤石动桔梗，头痛目赤，身体壮热。始觉发，即温酒饮之，随能数杯。酒势行则解。亦可服
大麦 良。复若不解，复服。
术对钟乳。术发则头痛目赤，或举身壮热。解与钟乳同。
附子对白石英，亦对赤石脂；附子发，则呕逆，手脚疼，体强，骨节痛，或项强，面目
满肿，饮酒食 自愈。若不愈，与白石英同解。
人参对紫石英，人参发，则烦热，头项强，解与紫石英同。
桔梗对赤石脂，又对茯苓，又对牡蛎。桔梗发，则头痛目赤，身体壮热，解与赤石同。
干姜无所偏对。
有说者云∶药性，草木则速发而易歇，土石则迟发而难歇也。夫服药，草、石俱下于喉
，其势厉盛衰，皆有先后。其始得效，皆是草木先盛耳，土石方引日月也。草木少时便歇，
石势犹自未成。其疾者不解消息，便谓顿休，续后更服；或谓病痼药微，倍更增石；或更杂
服众石；非一也。石之为性，其精华之气，则合五行，乃益五脏，其滓秽便同灰土也。夫病
家气血虚少，不能宣通，杂石之性卒相和合，更相尘瘀，便成牢积。其病身不知是石不和，
精华不发，不能致热消疾，便谓是冷盛牢剧，服之无已。不知石之为体，体冷性热，其精华
气性不发，其冷如冰。而疾者，其石入腹即热，既不即热，服之弥多，是以患冷癖之人不敢
寒食，而大服石，石数弥多，其冷癖尤剧，皆石性不发而积也。亦有杂饵诸石丸酒，单服异
石，初不息，惟以大散为数而已。有此诸害，其证甚多。
《短剧方》云∶道弘道人制《解散对治方》，说草石相对之和，有的能发动为证。世人
逐易，不逆思寻古今方说，至于动散，临急便就服之，既不救疾，便成委祸。大散由来是难
将之药，夫以大散难将，而未经服者，乃前有慎耳。既心期得益，苟就服之；已服之人，便
应研习救解之宜，异日动之，便得自救也。夫身有五石之药，而门内无解救之人，轻信对治
新方，逐易服之，从非弃是，不当枉命误药邪？检《神农本草经》，说草石性味，无对治之
和，无指的发动之说。按其对治之和，亦根据本草之说耳。且《大散方》说主患，注药物，不
说其所主治，亦不说对和指的发动之性也。览皇甫士安撰《解散说》及将服消息节度，亦无
对和的发之说也。复有廪丘家，将温法以救变败之色，亦无对和的动之说。若以药性相对为
神者，栝蒌恶干姜，此是对之大害者。道弘说对治而不辨此，道弘之方焉可从乎？今不从也
。当从皇甫节度，自更改栝蒌，便为良矣。患热则不服其药，惟患冷者服之耳，自可以除栝
蒌；若虚劳脚弱者，以石斛十分代栝蒌；若风冷上气咳者，当以紫菀十分代栝蒌。二法极良
。若杂患常疾者，止除栝蒌而已，慎勿加余物。
皇甫云∶然寒食药者，世莫知焉，或言华佗，或曰仲景。考之于实∶佗之精微，方类单
省，而仲景经有侯氏黑散、紫石英方，皆数种相出入，节度略同；然则寒食草、石二方，出
自仲景，非佗也。且佗之为治，或刳断肠胃，涤洗五脏，不纯任方也。仲景虽精，不及于佗
。至于审方物之候，论草石之宜，亦妙绝众医。及寒食之疗者，御之至难，将之甚苦。近世
尚书何晏，耽声好色，始服此药，心加开朗，体力转强，京师翕然，传以相授。历岁之困，
皆不终朝而愈。众人喜于近利，未睹后患。晏死之后，服者弥繁，于时不辍，余亦豫焉。或
暴发不常，夭害年命，是以族弟长互，舌缩入喉；东海王良夫，痈疮陷背；陇西辛长绪，脊
肉烂溃；蜀郡赵公烈，中表六丧；悉寒食散之所为也。远者数十岁，近者五六岁；余虽视息
，犹溺人之笑耳。而世人之患病者，由不能以斯为戒，失节之人，多来问余，乃喟然叹曰∶
今之医官，精方不及华佗，审治莫如仲景，而竞服至难之药，以招甚苦之患，其夭死者焉可
胜计哉？咸宁四年，平阳太守刘泰，亦沉斯病，使使问余救解之宜。先时有姜子者，以药困
绝，余实生之，是以闻焉。然身自荷毒，虽才士不能书，辨者不能说也。苟思所不逮，暴至
不旋踵，敢以教人乎？辞不获已，乃退而惟之，求诸《本草》，考以《素问》，寻故事之所
更，参气物之相使，并列四方之本，注释其下，集而与之。匪曰我能也，盖三折臂者为医，
非生而知之，试验亦其次也。
服寒食散，二两为剂，分作三帖。清旦温醇酒服一帖，移日一丈，复服一帖，移日二丈
，复服一帖，如此三帖尽。须臾，以寒水洗手足，药气两行者，当小痹，便因脱衣，以冷水
极浴，药势益行，周体凉了，心意开朗，所患即瘥。虽羸困着床，皆不终日而愈。人有强弱
，有耐药；若人羸弱者，可先小食，乃服；若人强者，不须食也。有至三剂，药不行者，病
人有宿癖者，不可便服也，当先服消石大丸下去，乃可服之。
服药之后，宜烦劳。若羸着床不能行者，扶起行之。常当寒衣、寒饮、寒食、寒卧，极
寒益善。
若药未散者，不可浴，浴之则矜寒，使药噤不发，令人战掉，当更温酒饮食，起跳踊，
舂磨出力，令温乃浴，解则止，勿过多也。又当数令食，无昼夜也。一日可六七食，若失食
，饥亦令人寒，但食则温矣。
若老小不耐药者，可减二两，强者过二两。
少小气盛及产妇卧不起，头不去巾帽，浓衣对火者，服散之后，便去衣巾，将冷如法，
勿疑也。虚人亦治，又与此药相宜。实人勿服也。药虽良，令人气力兼倍，然甚难将息，适
大要在能善消息节度，专心候察，不可失意，当绝人事。唯病着床，虚所不能言，厌病者，
精意能尽药意者，乃可服耳。小病不能自劳者，必废失节度，慎勿服也。
若伤寒者，大下后乃服之，便极饮冷水。若产妇中风寒，身体强痛，不得动摇者，便温
服一剂，因以寒水浴即瘥。以浴后，身有痹处者，便以寒水洗，使周遍，初得小冷，当数食
饮酒于意。后愦愦不了快者，当复冷水浴，以病甚者，水略不去体也。若药偏在一处，偏痛
、偏冷、偏热、偏痹及眩烦腹满者，便以水逐洗，于水下即了了矣。如此昼夜洗，药力尽乃
止。
凡服此药，不令人吐下也，病皆愈。若膈上大满欲吐者，便 食即安矣。服药之后
，大盒饭变于常，故小青黑色，是药染耳，勿怪之也。若亦温温欲吐，当遂吐之，不令极也
。明旦当更服。
若浴晚者，药势必不行，则不堪冷浴，不可强也，当如法更服之。凡洗太早，则药禁寒
；太晚，则吐乱，不可失过也。寒则出力洗，吐则速冷食。若以饥为寒者，食自温。常当将
冷，不可热炙之也。若温衣、温食、温卧，则吐逆颠覆矣，但冷冻饮料食、冷浴则瘥矣。
凡服药者，服食皆冷，唯酒冷热自从。或一月而解，或二十余日解，当饮酒，令体中醺
醺不绝。当饮醇酒，勿饮薄白酒也，体内重，令人变乱。若不发者，要当先下，乃服之也。
寒食药得节度者，一月转解，或二十日解。堪温不堪寒，即以解之候也。
其失节度者，头痛欲裂，坐服药食温作癖，急宜下之。
或两目欲脱，坐犯热在肝，速下之，将冷自止。
或腰痛欲毙，坐衣浓体温，以冷洗浴，冷石熨也。
或眩冒欲蹶，坐衣裳犯热，宜淋头，冷洗之。
或腰疼欲折，坐久坐下温，宜常令床上冷水洗也。
或腹胀欲决，甚者断衣带，坐寝处久下热，又得温、失食、失洗、不起行，但冷食、冷
洗、当风立。
或心痛如剌，坐当食而不食，当洗而不洗，寒热相结，气不通，结在心中，口噤不得息
，当校口，但与热酒，任本性多少，其令酒气两得行，气自通。得噫，因以冷水浇淹手巾，
着所苦处，温复易之，自解。解便速冷食，能多益善。于诸痛之内，心痛最急，救之若赴汤
火，乃可济耳。
或有气断绝，不知人，时蹶，口不得开，病者不自知，当须傍人救之。要以热酒为性命
之本。不得下者，当斫齿，以酒灌咽中。咽中塞逆，酒入腹还出者，但与勿止也。出复内之
，如此或半日，酒下气苏，酒不下者，便杀人也。
或下利如寒中，坐行止食饮犯热所致，人多疑冷病。人又滞癖，皆犯热所为，慎勿疑也
，速脱衣、冷食饮、冷洗也。
或百节酸疼，坐卧太浓，又入温被中，衣温不脱衣故也。卧下当极薄，单布不着棉
也。当薄且垢故，勿着新衣，多着故也。虽冬寒，常当被头受风，以冷石熨，衣带不得系也。
若犯此酸闷者，但入冷水浴，勿忍病而畏浴也。
或矜战恶寒，如伤寒，或发热如疟，坐失食忍饥，洗冷不行。又坐食臭故也。急冷洗起
行。
或恶食如臭物，坐温食作癖也，当急下之。若不下，万救终不瘥也。
或咽中痛，鼻塞，清涕出，坐温衣近火故也。但脱衣，冷水洗，当风，以冷石熨咽颡五
六遍自瘥。
或胸胁气逆，干呕，坐饥而不食，药气熏膈故也。但冷食、冷冻饮料、冷洗即瘥。
或食下便出，不得安坐，有癖，但下之。
或淋不得小便，为入坐温处及骑马鞍，热入膀胱也。冷食，以冷水洗小腹，以冷石熨，
一日即止。
或大行难，腹中牢固如蛇盘，坐犯温，入积腹中，干粪不去故也。消酥若膏，便寒服一
二升，浸润则下；不下，更服即瘥。
或寒栗头掉，不自支任，坐食少，药气行于肌肤，五脏失守，百脉摇动，与正气争
竞故也。努力强饮热酒，以和其脉；强冷食、冷冻饮料，以定其脏；强起行，以调其关节。酒行
食充，关节以调，则洗了矣。云了者，是瑟然病除，神明了然之状也。
或关节强直，不可屈伸，坐久停息，不自烦劳，药气停止，络结不散越，沉滞于血中故
也。任力自温，便冷洗即瘥。云任力自温者，令行动出力，从劳则发温也，非浓衣近火之温
也。
或小便稠数，坐热食及啖诸含热物饼黍之属故也。以冷水洗少腹，服栀子汤即瘥。
或失气不可禁止者，坐犯温不时洗故也。冷洗自寒即止。
或遗粪不自觉，坐久坐下温，热气上入胃，大肠不禁故也。冷洗即瘥。
或目痛如剌，坐热，热气冲肝，上奔两眼故也。勤冷食，清旦温小便洗，不过三日即瘥
。
或耳鸣如风声，汁出，坐自劳出力过矣，房室不节，气迸奔耳故也。勤好饮食，稍稍行
步，数食节情即止。
或口伤舌强烂燥，不得食，坐食少，谷气不足，药在胃脘中故也。急作栀子豉汤。
或手足偏痛，诸节解、身体发痈疮硬结，坐寝处久不自移徙，暴热偏并，聚在一处
强中病，表现为阴茎持续勃起不痿软，精液自行流出。这是由于年轻时服用五石散，五石的燥热之气滞留于肾中，导致下焦虚热。在年少壮盛之时，气血充沛，尚能制约五石的药性；等到年老体衰，气血减少，肾虚无法再制约精液。如果精液枯竭，各种疾病就会产生。
所谓“散脉”，有的洪大有力；有的断续不足，看似死脉；有的细而数急；有的弦而急促。这是因为坐卧起居触犯禁忌不一，所以脉象没有固定规律，医生难以识别。热邪多则脉弦急，有积块则脉洪实，剧烈疼痛则脉断续。凡是寒食散引发的脉象大多如此。如果没有痛苦，就不是死证。只要勤于遵守调养节度，如果不遵守节度就会死亡。
想要服用散剂，应当诊察脉象；仔细审察脉候，然后才能痊愈。脉沉数的，药力难发；难发时应当多次使用泻法。脉浮大的，药力易发。有人服用散剂两三剂后药力未发，这是因为此人脉沉难发，药力发动时人不自觉，药势已在体内运行，只是没有表现在外部。想要观察药力是否生效，第一候是进食增多；第二候是气机下行，面色和悦；第三候是头面身体瘙痒；第四候是阵阵恶风；第五候是昏昏欲睡。凡是有这些证候的，都是药力在五脏内部发动，没有表现于外，只要按照方法服用散剂，不要怀疑。如果多次使用泻法，会导致内虚，药力自然会发动。
各方说法互有不同：皇甫谧只主张用冷法，廪丘公主张用暖法。这大多与情志有关。世人未能掌握其深奥趣味，所以很少能正确使用。然而他们的方法，还有很多不完善之处，只谈论服药开始时的调养程度，不说发动之后的处理。治疗的适宜方法，多有缺失遗漏。江左有道弘道人，深刻识得法度体制，凡所救治，灵验如神，制定了《解散对治方》，说：
钟乳石配白术，又配瓜蒌，主要治疗肺系疾病，上通头胸。白术扰动钟乳石，会导致胸塞短气；钟乳石扰动白术，会导致头痛目疼。另外，钟乳石虽然不配海蛤，但海蛤扰动钟乳石会导致目痛短气。有时白术扰动钟乳石，直接导致头痛胸塞。然而钟乳石与白术可能产生的病患，不过如此。虽然病患不同，治疗方法也是一样的。发动之初，要探究其原因，刚开始觉得身体中有异常，与上述病患相应，便迅速服用葱白豉汤。
又说：硫黄配防风，又配细辛，主要治疗脾肾，通达腰脚。防风、细辛扰动硫黄，会导致烦疼腰痛，或喜怒无常，或腹泻不止。防风、细辛能动摇硫黄，硫黄不能动摇它们。刚开始觉得发作，便服用杜仲汤。
白石英配附子，主要治疗胃，通达至脾肾。附子扰动白石英，会导致烦闷腹胀；白石英扰动附子，则呕吐逆气不能进食，或牙关紧闭不开，或言语困难，手脚疼痛。感觉发作，服用生麦门冬汤。
紫石英配人参，主要治疗心肝，通达至腰脚。人参扰动紫石英，会导致心急而痛，或惊悸不能睡眠；或恍惚遗忘失误，失性狂发；或神情抑郁想睡，或昏乱喜笑，或病情好转或加重，忽冷忽热；或耳聋目暗。另外，防风虽然不配紫石英，但能扰动紫石英，紫石英因防风而扰动人参。人参被扰动，也会心痛烦热，头项强直。刚开始觉得发作，便适宜服用麻黄汤。
赤石脂配桔梗，主要治疗心，通达至胸背。桔梗扰动赤石脂，会导致心痛口噤，手足逆冷，心中烦闷；赤石脂扰动桔梗，会导致头痛目赤，身体壮热。刚开始觉得发作，即用温酒送服，随能力多喝几杯。酒力运行则病解。也可以服用大麦良（注：此处原文可能有误，通常指某种食疗或药物，依原文保留）。如果还不解，再服用。
白术配钟乳石。白术发动则头痛目赤，或全身壮热。解救方法与钟乳石相同。
附子配白石英，也配赤石脂；附子发动，则呕吐逆气，手脚疼，身体强直，骨节痛，或项强，面目浮肿，饮酒吃饭自愈。如果不好，与白石英的解救方法相同。
人参配紫石英，人参发动，则烦热，头项强直，解救方法与紫石英相同。
桔梗配赤石脂，又配茯苓，又配牡蛎。桔梗发动，则头痛目赤，身体壮热，解救方法与赤石脂相同。
干姜没有特定的相对配伍。
有人说：药性方面，草木类药物发作快而易停止，土石类药物发作慢而难停止。服药时，草、石类药物一起吞下喉中，其气势的盛衰，都有先后顺序。刚开始见效，都是草木类药力先盛，土石类药力才逐渐引动。草木类药力小时就停止了，石类药势还未形成。那些不懂疾病消长变化的人，便以为药力完全停止，随后再次服药；或认为病顽固药力微弱，加倍增加石药；或混杂服用多种石药，情况不一。石类的性质，其精华之气，合于五行，能补益五脏，其渣滓秽物就像灰土一样。病人气血虚弱，不能宣通，杂合石药的性质突然相和合，互相尘瘀，便成为牢固的积块。病人不知道这是石药不和，精华不发，不能产生热效以消除疾病，便认为是冷邪盛实牢固剧烈，不停地服用。不知道石类的本体，体质寒冷而性质温热，其精华气性不发，其寒冷如冰。而病人，石药入腹即热，如果不立即发热，服用越多，因此患冷癖的人不敢吃寒食，而大量服用石药，石药数量越多，其冷癖越严重，都是因为石性不发而积聚所致。也有混杂食用各种石药丸酒，单独服用异石，起初不停止，只是以大散的数量为准。有这些危害，证候很多。
《短剧方》说：道弘道人制定《解散对治方》，说明草石相对的和谐，有的能发动作为证候。世人追逐简易，不逆向思考探寻古今方书说法，至于动散，临急便去服用，既不能救疾，便成为推卸祸责。大散向来是难调护的药物，因为大散难调护，而没有服用过的人，乃是出于谨慎。既然心里期望得到益处，苟且去服用；已经服用的人，便应该研习救解的适宜方法，日后发作，便能自救。身上有五石之药，而门内没有解救之人，轻信对治的新方，追逐简易去服用，舍正从非，难道不是枉费性命误用药物吗？检阅《神农本草经》，说草石性味，没有对治的和合之说，没有明确的发动之说。按其对治的和合，也是根据本草的说法罢了。而且《大散方》说主治病患，注释药物，不说其所主治，也不说对和指的发动之性。看皇甫士安撰写的《解散说》及将服消息节度，也没有对和的发之说。又有廪丘家，用温法来救治变败之色，也没有对和的动之说。如果认为药性相对为神奇，栝蒌恶干姜，这是对之大害者。道弘说对治而不辨别这一点，道弘的方子怎么能听从呢？现在不听从。应当遵从皇甫的节度，自行更改栝蒌，就是好的了。患热症就不服用该药，只有患冷症的人才服用它，自然可以去除栝蒌；如果虚劳脚弱的人，用十分石斛代替栝蒌；如果风冷上气咳嗽的人，当用十分紫菀代替栝蒌。这两种方法极好。如果有杂患常疾的人，只除去栝蒌而已，千万不要添加其他东西。
皇甫说：然而寒食药，世人无人知晓，有人说华佗，有人说张仲景。考证其实：华佗的精微之处，方剂类别单简省约，而张仲景的经书中有关氏黑散、紫石英方，都几种药物相互出入，节度大致相同；那么寒食草、石二方，出自张仲景，不是华佗。而且华佗的治疗，有的剖断肠胃，涤洗五脏，不纯粹依赖方药。张仲景虽然精妙，不及华佗。至于审察方物之候，论述草石之宜，也妙绝众医。至于寒食的疗法，驾驭极其困难，调护非常辛苦。近代尚书何晏，沉迷声色，开始服用此药，心胸更加开朗，体力转强，京城一致，相传以此授受。历年的困顿，都不到一天就痊愈了。众人喜欢近利，未看到后患。何晏死后，服用的人更多，当时不停止，我也参与其中。有的突然发作不常，夭折损害寿命，因此族弟长互，舌头缩入喉中；东海王良夫，痈疮陷背；陇西辛长绪，脊肉烂溃；蜀郡赵公烈，中表六丧；都是寒食散造成的。远的几十年，近的五六岁；我虽然还活着，还是被人嘲笑溺爱之人。而世人的患病者，由于不能以此为戒，失去节度的人，多来问我，于是感叹说：现在的医官，精通方药不及华佗，审察治疗不如张仲景，却竞相服用极难的药物，招致极大的苦难，夭折死亡的怎能计算得尽呢？咸宁四年，平阳太守刘泰，也沉浸在此病中，派使者问我救解的适宜方法。先前有姜子，因药困绝，我确实救活了他，所以听闻此事。然而我自己承受毒性，虽然是才士也不能书写，善辩的人也不能解说。如果思考所不及，暴至不转眼之间，敢用来教人吗？言辞不被允许，于是退而思考，求诸《本草》，考以《素问》，寻找故事所更替的，参合气物相使的关系，并列四方之本，注释其下，集而给予他。不是说我能做到，大概是三折臂者为医，不是生而知之，试验也是其次。
服用寒食散，二两为一剂，分作三帖。清晨温醇酒服一帖，走一丈路，再服一帖，走二丈路，再服一帖，这样三帖服完。片刻后，用冷水洗手足，药气两行者，应当轻微麻痹，便脱衣，用冷水极浴，药势更加运行，周身凉透，心意开朗，所患即愈。即使瘦弱困顿卧床，都不到一天就痊愈。人有强弱，有耐药；如果人瘦弱，可以先少量进食，然后服用；如果人强壮，不需要进食。有的人至三剂，药不行者，病人有宿癖者，不可以立即服用，应当先服用消石大丸下去，然后才可以服用。
服药之后，应当烦劳。如果瘦弱卧床不能行走的，扶起让他行走。常应当穿寒衣、喝寒饮、吃寒食、睡寒卧，极寒越好。
如果药未散者，不可以洗浴，洗浴则会矜持寒冷，使药噤不发，令人战栗发抖，应当再用温酒饮食，起跳踊，舂磨出力，令温暖然后洗浴，解则停止，不要过多。又应当多次让进食，无昼夜之分。一天可六七食，如果失食，饥饿也令人寒冷，但进食则温暖了。
如果老小不耐药者，可减少二两，强者超过二两。
少小气盛及产妇卧不起，头不去巾帽，浓衣对火者，服散之后，便去衣巾，将冷如法，不要怀疑。虚人也能治，又与此药相宜。实人勿服。药虽好，令人气力加倍，然而很难调护，关键所在在于善于消息节度，专心候察，不可失意，应当断绝人事。只有病着床，虚所不能言，厌病者，精意能尽药意者，才可以服用。小病不能自劳者，必废失节度，千万不要服用。
如果伤寒者，大下后才服用它，便极饮冷水。如果产妇中风寒，身体强痛，不得动摇者，便温服一剂，因以寒水浴即愈。因为浴后，身有痹处者，便以寒水洗，使周遍，初得小冷，应当多次食饮酒于意。后愦愦不了快者，应当再冷水浴，以病甚者，水略不去体也。如果药偏在一处，偏痛、偏冷、偏热、偏痹及眩烦腹满者，便以水逐洗，于水下即了了矣。如此昼夜洗，药力尽乃止。
凡是服用此药，不令人吐下也，病皆愈。如果膈上大满欲吐者，便进食即安矣。服药之后，大便变为青黑色，是药染耳，不要奇怪。如果也温温欲吐，应当遂吐之，不令极也。明旦当更服。
如果洗浴晚者，药势必不行，则不堪冷浴，不可以勉强，应当如法更服之。凡是洗太早，则药禁寒；太晚，则吐乱，不可以错过。寒则出力洗，吐则速冷食。如果以饥为寒者，食自温。常应当将冷，不可以热炙之也。如果温衣、温食、温卧，则吐逆颠覆矣，但冷冻饮料食、冷浴则愈矣。
凡是服药者，服食皆冷，唯酒冷热自从。或一月而解，或二十余日解，当饮酒，令体中醺醺不绝。当饮醇酒，勿饮薄白酒也，体内重，令人变乱。如果不发者，要当先下，乃服之也。
寒食药得节度者，一月转解，或二十日解。堪温不堪寒，即以解之候也。
或两目欲脱，坐犯热在肝，速下之，将冷自止。
或腰痛欲毙，坐衣浓体温，以冷洗浴，冷石熨也。
或腰疼欲折，坐久坐下温，宜常令床上冷水洗也。
或腹胀欲决，甚者断衣带，坐寝处久下热，又得温、失食、失洗、不起行，但冷食、冷洗、当风立。
或心痛如刺，坐当食而不食，当洗而不洗，寒热相结，气不通，结在心中，口噤不得息，当校口，但与热酒，任本性多少，其令酒气两得行，气自通。得噫，因以冷水浇淹手巾，着所苦处，温复易之，自解。解便速冷食，能多益善。于诸痛之内，心痛最急，救之若赴汤火，乃可济耳。
或有气断绝，不知人，时蹶，口不得开，病者不自知，当须傍人救之。要以热酒为性命之本。不得下者，当斫齿，以酒灌咽中。咽中塞逆，酒入腹还出者，但与勿止也。出复内之，如此或半日，酒下气苏，酒不下者，便杀人也。
或下利如寒中，坐行止食饮犯热所致，人多疑冷病。人又滞癖，皆犯热所为，慎勿疑也，速脱衣、冷食饮、冷洗也。
或百节酸疼，坐卧太浓，又入温被中，衣温不脱衣故也。卧下当极薄，单布不着棉也。当薄且垢故，勿着新衣，多着故也。虽冬寒，常当被头受风，以冷石熨，衣带不得系也。
若犯此酸闷者，但入冷水浴，勿忍病而畏浴也。
或矜战恶寒，如伤寒，或发热如疟，坐失食忍饥，洗冷不行。又坐食臭故也。急冷洗起行。
或恶食如臭物，坐温食作癖也，当急下之。若不下，万救终不瘥也。
或咽中痛，鼻塞，清涕出，坐温衣近火故也。但脱衣，冷水洗，当风，以冷石熨咽颡五六遍自瘥。
或胸胁气逆，干呕，坐饥而不食，药气熏膈故也。但冷食、冷冻饮料、冷洗即瘥。
或食下便出，不得安坐，有癖，但下之。
或淋不得小便，为入坐温处及骑马鞍，热入膀胱也。冷食，以冷水洗小腹，以冷石熨，一日即止。
或大行难，腹中牢固如蛇盘，坐犯温，入积腹中，干粪不去故也。消酥若膏，便寒服一二升，浸润则下；不下，更服即瘥。
或寒栗头掉，不自支任，坐食少，药气行于肌肤，五脏失守，百脉摇动，与正气争竞故也。努力强饮热酒，以和其脉；强冷食、冷冻饮料，以定其脏；强起行，以调其关节。酒行食充，关节以调，则洗了矣。云了者，是瑟然病除，神明了然之状也。
或关节强直，不可屈伸，坐久停息，不自烦劳，药气停止，络结不散越，沉滞于血中故也。任力自温，便冷洗即瘥。云任力自温者，令行动出力，从劳则发温也，非浓衣近火之温也。
或小便稠数，坐热食及啖诸含热物饼黍之属故也。以冷水洗少腹，服栀子汤即瘥。
或失气不可禁止者，坐犯温不时洗故也。冷洗自寒即止。
或遗粪不自觉，坐久坐下温，热气上入胃，大肠不禁故也。冷洗即瘥。
或目痛如刺，坐热，热气冲肝，上奔两眼故也。勤冷食，清旦温小便洗，不过三日即瘥。
或耳鸣如风声，汁出，坐自劳出力过矣，房室不节，气迸奔耳故也。勤好饮食，稍稍行步，数食节情即止。
或口伤舌强烂燥，不得食，坐食少，谷气不足，药在胃脘中故也。急作栀子豉汤。
或手足偏痛，诸节解、身体发痈疮硬结，坐寝处久不自移徙，暴热偏并，聚在一处
The disease of Qiangzhong (Strong Middle) is characterized by persistent erection of the penis without flaccidity and spontaneous emission of essence. This is caused by taking Wushi San (Five-Mineral Powder) in one's youth; the heat of the five minerals remains stagnant in the kidneys, causing deficiency-heat in the lower jiao. In one's prime, when blood and qi are abundant, they can restrain the effects of the five minerals. However, as one ages and declines, blood and qi diminish, and kidney deficiency renders it unable to control the essence. If the essence is exhausted, various diseases will arise.
Regarding the "San Mai" (Powder Pulse), it may be surging and solid; or intermittent and insufficient, resembling a death pulse; or fine and rapid; or wiry and fast. This is because sitting, lying, and daily activities involve different violations of dietary and behavioral restrictions, so the pulse has no fixed pattern, making it difficult for physicians to identify. When heat is excessive, the pulse is wiry and rapid; when there are masses, the pulse is surging and solid; when there is acute pain, the pulse is intermittent. The pulses induced by Hanshi San (Cold-Food Powder) are generally like this. If there is no suffering, it is not a death sign. Diligently adhering to regulation and restraint prevents death; failure to do so leads to death.
To take the powder, one should diagnose the pulse; carefully examine the pulse signs, and only then can recovery be achieved. A deep and rapid pulse indicates difficulty in the medicine's activation; if difficult to activate, purgatives should be administered repeatedly. A floating and large pulse indicates ease of activation. Some people take two or three doses of the powder without activation; this is because their pulse is deep and hard to activate. The activation does not make them feel it; the medicinal force acts internally but does not manifest externally. To observe if the medicine is effective: the first sign is increased appetite; the second is downward movement of qi with a harmonious and pleasant complexion; the third is itching of the head, face, and body; the fourth is periodic aversion to wind; the fifth is drowsiness. Those with these signs indicate that the medicine is activating the internal organs without external manifestation. Follow the method of taking the powder without doubt. Repeated purgation causes internal deficiency, leading to natural activation.
Different prescriptions vary: Huangfu Mi advocated only cold methods, while Lord Linqiu advocated warm methods. This largely relates to emotional states. People of the world have not grasped its profound interest, so few use it correctly. However, their methods are incomplete, discussing only the initial stage of taking medicine and the degree of care, but not what happens after activation. The appropriate treatments are often lacking. Dao Hong Daoren from Jiangzuo deeply understood the principles and methods. His cures were miraculous. He formulated the *Jie San Dui Zhi Fang* (Formula for Counteracting Powder Activation), stating:
Zhuru (Stalactite) counters Baizhu (Atractylodes Macrocephala Rhizome) and Gualou (Trichosanthes Fruit). It mainly treats the lungs, connecting to the head and chest. Baizhu stirring Zhuru causes chest fullness and shortness of breath; Zhuru stirring Baizhu causes headache and eye pain. Although Zhuru does not counter Haige (Clam Shell), Haige stirring Zhuru causes eye pain and shortness of breath. Sometimes Baizhu stirring Zhuru directly causes headache and chest fullness. The ailments caused by Zhuru and Baizhu are limited to this. Although the ailments differ, the treatment is the same. At the beginning of activation, investigate the cause. If you feel abnormal sensations corresponding to the above ailments, quickly consume Congbai Chi Tang (Scallion White and Fermented Soybean Decoction).
Also: Huang (Sulfur) counters Fangfeng (Saposhnikovia Root) and Xixin (Asarum Root). It mainly treats the spleen and kidneys, connecting to the waist and legs. Fangfeng and Xixin stirring Huang causes painful irritation and lower back pain, or erratic emotions, or uncontrollable diarrhea. Fangfeng and Xixin can stir Huang, but Huang cannot stir them. At the first sign of activation, consume Duzhong Tang (Eucommia Bark Decoction).
Baishiying (White Quartz) counters Fuzi (Prepared Aconite Lateralis Radix). It mainly treats the stomach, connecting to the spleen and kidneys. Fuzi stirring Baishiying causes irritability and abdominal distension; Baishiying stirring Fuzi causes vomiting and inability to eat, or locked jaw, or difficulty speaking, or pain in hands and feet. At the first sign, consume Sheng Maidong Tang (Fresh Ophiopogon Decoction).
Zishiying (Purple Quartz) counters Renshen (Ginseng Radix et Rhizoma). It mainly treats the heart and liver, connecting to the waist and legs. Renshen stirring Zishiying causes heart anxiety and pain, or palpitations and insomnia; or confusion and forgetfulness, madness; or depression and sleepiness, or irritability and laughter; or fluctuating improvement and worsening, alternating chills and fever; or deafness and dim vision. Although Fangfeng does not counter Zishiying, it can stir it, and Zishiying, due to Fangfeng, stirs Renshen. Stirred Renshen also causes heart pain, irritability, and stiffness of the head and neck. At the first sign, it is suitable to consume Mahuang Tang (Ephedra Decoction).
Chishizhi (Red Halloysite) counters Jiegeng (Platycodon Root). It mainly treats the heart, connecting to the chest and back. Jiegeng stirring Chishizhi causes heart pain, locked jaw, cold extremities, and mental restlessness; Chishizhi stirring Jiegeng causes headache, red eyes, and high fever. At the first sign, drink with warm wine, taking several cups as tolerated. The effect of the wine resolves the condition. Alternatively, consume Damai Liang (Barley). If unresolved, take again.
Baizhu counters Zhuru. Activation of Baizhu causes headache, red eyes, or generalized high fever. The resolution is the same as for Zhuru.
Fuzi counters Baishiying and also Chishizhi. Activation of Fuzi causes vomiting, pain in hands and feet, body stiffness, joint pain, stiff neck, and swelling of the face and eyes. Eating and drinking wine heals it. If not healed, use the resolution for Baishiying.
Renshen counters Zishiying. Activation of Renshen causes irritability and stiffness of the head and neck. The resolution is the same as for Zishiying.
Jiegeng counters Chishizhi, also Fuling (Poria), and Muli (Oyster Shell). Activation of Jiegeng causes headache, red eyes, and high fever. The resolution is the same as for Chishizhi.
Ganjiang (Dried Ginger) has no specific counter-agent.
Some say: Herbal medicines act quickly and stop easily; mineral medicines act slowly and are hard to stop. When taking medicine, herbs and minerals are swallowed together, but their momentum rises and falls with a sequence. Initial efficacy is due to herbs being dominant first, while minerals take time to induce. Herbs stop when small in amount, while mineral momentum has not yet formed. Those who do not understand the waxing and waning of disease think the medicine has completely stopped and take more; or believe the disease is stubborn and the medicine weak, increasing minerals; or mix various minerals. The nature of minerals: their essence combines with the Five Elements, benefiting the five zang organs; their dregs are like ash and soil. Patients with deficient blood and qi cannot circulate freely. Mixing mineral natures suddenly combines them, creating turbid stagnation and firm accumulations. Patients do not realize it is mineral incompatibility, lack of essence release, and inability to generate heat to eliminate disease. They mistakenly believe it is severe cold accumulation and continue taking it. They do not know that minerals have a cold body and hot nature. If the essence does not release, it feels cold as ice. Once minerals enter the abdomen, they become hot. If not immediately hot, taking more worsens the condition. Thus, those with cold accumulation dare not eat cold foods but take large amounts of minerals, worsening their condition due to un-released mineral nature. Some mix mineral pills and wines, taking single minerals initially without stopping, just using the quantity of Da San (Great Powder). These harms lead to many symptoms.
*Duan Ju Fang* (Short Drama Formula) states: Dao Hong Daoren formulated *Jie San Dui Zhi Fang*, explaining the harmony of herbs and minerals, some of which can activate symptoms. People follow easy methods, failing to reflect on ancient and modern formulas. When powder activates, they take remedies hastily, failing to cure the disease and shifting blame. Da San has always been difficult to manage. Those who haven't taken it are cautious. Those expecting benefits take it rashly. Those who have taken it should study rescue methods to save themselves. Having five-mineral medicine at home but no rescuer, trusting new counter-formulas, and following easy methods instead of correct ones wastes life and misuses drugs. Checking *Shennong Bencao Jing*, herb and mineral properties and flavors have no counter-harmony or explicit activation statements. The counter-harmony is based on Bencao. *Da San Fang* discusses main ailments and notes drugs but doesn't explain treatment or activation properties. Huangfu Shi'an's *Jie San Shuo* and guidelines also lack such statements. Lord Linqiu used warm methods to treat discoloration but lacked counter-activation statements. If relative drug properties were divine, Gualou hating Ganjiang would be a major harm. Dao Hong discussed counter-treatment but didn't distinguish this; how can his formula be followed? Now, we do not follow it. Follow Huangfu's guidelines and change Gualou, which is good. For heat ailments, don't take the medicine; only cold ailments take it, naturally removing Gualou. For deficiency consumption and weak legs, replace Gualou with 10 parts Shihu (Dendrobium Stem). For wind-cold upper qi cough, replace Gualou with 10 parts Ziwan (Aster Root). Both methods are excellent. For miscellaneous chronic ailments, just remove Gualou; do not add other things.
Huangfu said: Hanshi medicine is unknown to the world. Some say Hua Tuo, others Zhang Zhongjing. Examining reality: Hua Tuo's subtleties involved simple and concise formulas, while Zhang Zhongjing's classics include Hou Shi Hei San (Black Powder of Hou Shi) and Zishi Ying Fang (Purple Quartz Formula), involving multiple ingredients with similar guidelines. Thus, Hanshi herb and mineral formulas originate from Zhang Zhongjing, not Hua Tuo. Hua Tuo's treatments included surgery and organ washing, not relying solely on formulas. Zhang Zhongjing was refined but inferior to Hua Tuo. Yet, in examining drug properties and discussing herb/mineral suitability, he surpassed other physicians. Hanshi therapy is extremely difficult to manage and care for. Recently, Minister He Yan, indulging in pleasure, took this medicine. His mind became clear, and strength increased. The capital admired and transmitted it. Years of illness were cured in less than a day. People liked immediate benefits, ignoring later disasters. After He Yan's death, users multiplied. I participated. Some suffered sudden attacks, shortening lives. My cousin Chang Hu had his tongue retract into the throat; Wang Liangfu of Donghai had abscesses sinking into his back; Xin Changxu of Longxi had rotting spinal flesh; Zhao Gong Lie of Shu lost six relatives. All were caused by Hanshi San. Some decades later, some within five to six years. Though I survive, I am mocked for loving danger. Sick people fail to learn this lesson. Those losing discipline ask me. I sigh: Current physicians are less skilled in formulas than Hua Tuo and less adept in diagnosis than Zhang Zhongjing, yet they compete to take difficult drugs, inviting severe suffering. Deaths are countless. In the fourth year of Xianning, Liu Tai, Governor of Pingyang, suffered this and asked for rescue advice. Previously, Jiang Zi was saved by me from drug-induced coma, so I was consulted. I myself bear toxicity. Though talented, I cannot write; though eloquent, I cannot speak. If I fail to consider, death comes instantly. Am I daring to teach? Reluctantly, I reflected, sought *Bencao*, examined *Suwen*, looked for historical precedents, analyzed qi and substance interactions, listed four directions' bases, annotated below, and compiled them for him. Not claiming ability, but knowing "three broken arms make a doctor," learning is not innate; trial and error is secondary.
Taking Hanshi San: Two liang per dose, divided into three portions. Take one portion with warm mellow wine in the early morning. Walk one zhang, take another portion. Walk two zhang, take the last portion. Finish three portions. Shortly after, wash hands and feet with cold water. When medicinal qi circulates, slight numbness occurs. Remove clothes and bathe thoroughly with cold water. Medicinal force increases, whole body cools, mind clears, and illness heals. Even weak patients bedridden recover within a day. Strength and drug tolerance vary. Weak patients should eat slightly before taking; strong patients need not eat. If after three doses the medicine doesn't work, and the patient has old masses, do not take it immediately. First take Xiaoshi Da Wan (Large Pill of Potassium Nitrate) to purge, then take the powder.
After taking medicine, engage in activity. If too weak to walk, support and make them walk. Always wear cold clothes, drink cold liquids, eat cold food, and sleep in cold conditions. Extreme cold is beneficial.
If medicine hasn't dispersed, do not bathe; bathing causes cold retention, preventing medicine activation, leading to shivering. Use warm wine and food, jump, grind grain, exert effort to warm up, then bathe. Stop when resolved; don't overdo it. Eat frequently, day and night. Six or seven times a day. Hunger causes cold; eating brings warmth.
Elderly and children intolerant to medicine reduce dose by two liang; strong individuals exceed two liang.
Children with vigorous qi, postpartum women unable to rise, those keeping hats on, or wearing thick clothes near fire: after taking powder, remove clothes and hats, apply cold methods as prescribed without doubt. Deficient persons can also be treated; this medicine suits them. Excess persons should not take it. Though good, it doubles energy, but care is difficult. Key lies in proper regulation, careful observation, avoiding disappointment, and cutting off social engagements. Only those bedridden, unable to speak, weary of illness, and fully committed to understanding the medicine should take it. Those with minor illnesses unable to exert themselves lose discipline; do not take it.
For Shanghan (Cold Damage), take it after severe purgation, drinking cold water excessively. For postpartum women with wind-cold, body stiffness, and immobility, take one dose with warm water, then bathe in cold water to heal. If numbness persists after bathing, wash with cold water thoroughly. Initially slightly cold, eat and drink wine as desired. If still confused and uncomfortable, bathe in cold water again. For severe cases, water stays on the body. If medicine concentrates in one area causing pain, cold, heat, numbness, dizziness, or abdominal fullness, wash with water until clear. Wash day and night until medicinal force ends.
This medicine does not cause vomiting or purging; all illnesses heal. If upper jiao fullness causes urge to vomit, eating brings relief. After taking medicine, stool turns dark green/black due to dye; do not be surprised. If mild urge to vomit, allow vomiting but not excessively. Take again next morning.
If bathing late, medicinal force won't circulate; cold bathing is unsuitable. Don't force it; retake medicine as prescribed. Bathing too early prohibits cold; too late causes vomiting chaos. Don't miss timing. Cold requires exertion in washing; vomiting requires quick cold food/drink. Hunger feels like cold; food warms. Always maintain cold; don't use heat. Warm clothes, food, and sleep cause vomiting and reversal. Frozen drinks/food and cold baths heal.
All food/drinks must be cold; wine temperature is optional. Resolution takes one month or twenty-plus days. Drink wine to maintain slight intoxication. Drink mellow wine, not thin white wine. Heavy internal feeling causes chaos. If not activating, purge first, then take.
With proper regulation, Hanshi medicine resolves in one month or twenty days. Tolerance to warmth but not cold indicates resolution signs.
Losing regulation causes splitting headaches, masses from warm food/medicine; purge urgently.
Eyes bulging due to liver heat; purge quickly, apply cold to stop.
Severe lower back pain from warm clothing; bathe cold, apply cold stone compress.
Dizziness and fainting from hot clothes; shower head, wash cold.
Lower back breaking pain from sitting on warm surfaces; wash bed with cold water regularly.
Abdominal distension threatening rupture, breaking belt, from long sitting on warm places, getting warm, missing meals/washing/walking. Eat cold, wash cold, stand in wind.
Heart pain like stabbing from skipping meals/washing, cold-heat knotting, qi blockage in heart, locked jaw, breathing difficulty. Force open mouth, give hot wine according to tolerance, allowing wine qi to circulate, qi flows freely. Burp, then soak hand towel in cold water, apply to painful area, replace with warm one, self-resolves. Quickly eat cold food afterward; more is better. Among pains, heart pain is most urgent; rescue like rushing into fire/water.
Qi interruption, unconsciousness, occasional fainting, mouth closed, unawareness. Requires bystander rescue. Hot wine is life-saving. If unable to swallow, cut teeth, pour wine into throat. If wine enters stomach and comes back out, keep pouring. Out and in, possibly half a day. Wine down, qi revives; wine not down, death ensues.
Diarrhea like cold invasion from walking/stopping/eating/drinking violating heat rules. People suspect cold disease. Stagnant masses also from heat violation. Don't doubt; quickly remove clothes, eat/drink cold, wash cold.
Joint soreness from thick bedding, warm quilts, warm clothes not removed. Sleep on very thin cloth, no cotton. Old, dirty clothes preferred over new. Even in winter cold, expose head to wind, apply cold stone compress, loosen belts.
If suffering sourness/stuffiness, bathe in cold water; don't endure illness fearing bathing.
Shivering and aversion to cold like Shanghan, or fever like malaria, from missing meals/hunger, cold washing ineffective. Also from eating smelly food. Urgent cold wash and walking.
Aversion to food smelling like rotten matter from warm food masses; purge urgently. Without purging, ten thousand cures won't heal.
Throat pain, nasal congestion, clear runny nose from warm clothes near fire. Remove clothes, wash cold, stand in wind, apply cold stone compress to throat/pharynx five to six times, self-heals.
Chest/hypochondriac qi rebellion, dry heaving from hunger without eating, medicinal qi steaming diaphragm. Eat cold, frozen drinks, wash cold, heals.
Food passes through immediately, unable to sit still, masses present; purge.
Difficulty urinating from sitting in warm places or riding saddles, heat entering bladder. Eat cold, wash lower abdomen with cold water, apply cold stone compress, stops in one day.
Constipation, abdomen hard like snake coil, from warming, accumulation in abdomen, dry feces not expelled. Melt butter/ghee, take one to two sheng cold, moistens and moves; if not, take more, heals.
Chills and head shaking, unable to support self, from little eating, medicinal qi moving in skin/muscle, five zang losing control, hundred vessels shaking, competing with healthy qi. Force drink hot wine to harmonize vessels; force cold food/drinks to settle zang; force walk to adjust joints. Wine circulates, food fills, joints adjust, washing completes. "Complete" means sickness removes severely, spirit becomes clear.
Joint stiffness, inability to bend/extend, from long rest, lack of exertion, medicinal qi stopping, collaterals knotting, stagnating in blood. Warm self by effort, wash cold, heals. "Warm self by effort" means moving and exerting generates warmth, not from thick clothes/near fire.
Thick/frequent urination from hot food and heat-containing items like cakes/millet. Wash lower abdomen with cold water, take Zhizi Tang (Gardenia Decoction), heals.
Uncontrollable flatulence from warming and irregular washing. Cold wash induces cold, stops.
Involuntary defecation from long sitting on warm surfaces, heat qi entering stomach, large intestine failing to control. Cold wash heals.
Eye pain like stabbing from heat, heat qi rushing to liver, ascending to eyes. Frequent cold eating, wash with warm urine in early morning, heals within three days.
Tinnitus like wind sound, discharge, from overexertion, immoderate sexual activity, qi bursting into ears. Good diet, gradual walking, frequent eating, regulating emotions, stops.
Mouth injury, stiff/rotten/dry tongue, unable to eat, from little eating, grain qi insufficient, medicine in stomach. Make Zhizi Chi Tang (Gardenia and Fermented Soybean Decoction) urgently.
Asymmetric pain in hands/feet, joint separation, body abscesses/hard knots, from long lying unmoved, sudden heat concentrating in one place.