初得病一二日，便成阳毒；或服药吐下后，变成阳毒。其病腰背痛，烦闷不安，
狂言欲走，或见鬼，或下利，其脉浮大而数，面赤斑斑如锦纹，咽喉痛，吐下脓血。五日可治，七
日不可治，升麻汤主之。（不可作煮散。）
升麻 当归 甘草（各二分） 雄黄（研，一分） 桂枝（一分） 鳖甲（半两） 蜀椒（半分）
咀，水二升，煎一升，去滓，温服一盏，食顷再服。温覆手足出汗，汗出则解，未解重作之，
得吐尤佳。
阳毒宜葛根龙胆汤。（方在可发汗证中。）
初得病一二日，便成阴毒；或服药六七日以上至十日，变成阴毒。其病身重背强，腹中绞痛，
咽喉不利，毒瓦斯攻心，心坚强，气不得息，呕逆，唇青面黑，四肢厥冷，其脉沉细而紧。仲景云∶
阴毒之候，身痛如被杖，喉咽痛。五六日可
治，七日不可治，甘草汤主之。（不可作煮散。）
甘草 鳖甲 升麻 当归 桂枝（各二分） 蜀椒（一分） 雄黄（一分）
咀，水三升，煎取一升，去滓。温温每饮一盏，食顷再服，温覆。中毒当汗吐之，汗吐则愈，
不吐再服之。
治阴毒反阴丹。
硫黄（五两，研末） 太阴玄精石（味咸者，研末） 硝石（研末，各二两）
用铁铫子先铺玄精石一半，次铺硝石一半，中间下硫黄，又以硝石盖硫黄，都以玄精石盖之，
用盏子合定，令三斤炭火烧令得所，勿以烟出多，急取出，以瓦盆合定地下，四面灰拥，勿令烟出。
直候冷，取细研，蒸饼心，丸豌豆大，艾汤下十五丸，病重加至二三十丸，此法甚验。喘促吐逆者，
入口便安；服此药三五服，觉不退，便于脐下一寸半灸之，须是大炷百壮，未愈可至二百壮；若手
足极冷，小便涩，小腹硬， 痛囊缩，即须更于脐下四寸，如前灸之，乃与当归四逆并反阴丹
频频与服，内外通逐方可解，若稍缓即死矣。当归四逆乃加吴茱萸生姜者是，慎勿与寻常利小便药。
此是阴毒，气结在小腹所致也。有见小便不通，便用炒盐及裹热药熨脐下，欲望小便通利，其冷气
在小腹之间，被热物所熨，无处通出，即奔上冲心，其死速矣。
又治阴毒硫黄丸。
硫黄（二两） 水银（一两）
同研入铫，洒少醋，慢火炒，欲似烟出，再出火，洒醋，如此三四遍，地上放冷研之，蒸饼丸
梧桐子大。每服二十、三十丸，艾汤吞下，日三服，食前。
阴毒，脉沉微欲绝，四肢逆冷，大躁而渴不止，附子饮子。
附子（一枚，半两以上者，炮，去皮尖，四破。）
以水九升，煎至三升，去附子，入瓶，油单紧封沉井底，候极冷，取饮之。仍下硫黄丸甚妙。
阴毒之为病，因汗下药性冷所变，多在四五日也；或素来阳气虚冷，始得病便成阴毒；或始因
伤风伤冷物，便成阴毒。其病六日内可治，过六日不可治。
Upon the onset of illness for one or two days, Yang Poison (Yang Du) forms immediately; or it transforms into Yang Poison after medication-induced vomiting or purgation. The symptoms include pain in the waist and back, mental restlessness and oppression, delirious speech with a desire to run, hallucinations of seeing ghosts, or diarrhea. The pulse is floating, large, and rapid. The face is red with mottled patterns resembling brocade. There is sore throat, and vomiting or defecation of pus and blood. It is treatable within five days, but untreatable after seven days. Shengma Tang (Cimicifugae Decoction) is the primary prescription. (Do not prepare as a decoction powder.)
Shengma (Rhizoma Cimicifugae), Danggui (Radix Angelicae Sinensis), Gancao (Radix Glycyrrhizae Preparata) [each 2 fen], Xionghuang (Realgar, prepared by grinding) [1 fen], Guizhi (Ramulus Cinnamomi) [1 fen], Biejia (Carapax et Plastrum Testudinis) [0.5 liang], Shujiao (Fructus Zanthoxyli) [0.5 fen]. Cut the herbs, add two sheng of water, boil to one sheng, strain, and take one zhan warm. After a meal interval, take again. Cover warmly to induce sweating from hands and feet; resolution occurs with sweat. If unresolved, repeat the preparation. Induction of vomiting is particularly beneficial.
For Yang Poison, Gegen Longdan Tang (Puerariae Radix and Gentianae Decoctum) is suitable. (The formula is located in the section on "Syndromes Suitable for Diaphoresis".)
Upon the onset of illness for one or two days, Yin Poison (Yin Du) forms immediately; or it transforms into Yin Poison after medication over six or seven days up to ten days. The symptoms include heavy body and stiff back, severe colicky abdominal pain, dysphagia or throat obstruction, toxic qi attacking the heart, hardness in the cardiac region, dyspnea, vomiting and regurgitation, cyanotic lips and blackened complexion, cold limbs, and a pulse that is deep, fine, and tight. Zhang Zhongjing stated: In Yin Poison syndrome, the body aches as if beaten by a club, accompanied by sore throat. It is treatable within five to six days, but untreatable after seven days. Gancao Tang (Glycyrrhizae Decoctum) is the primary prescription. (Do not prepare as a decoction powder.)
Gancao (Radix Glycyrrhizae Preparata), Biejia (Carapax et Plastrum Testudinis), Shengma (Rhizoma Cimicifugae), Danggui (Radix Angelicae Sinensis), Guizhi (Ramulus Cinnamomi) [each 2 fen], Shujiao (Fructus Zanthoxyli) [1 fen], Xionghuang (Realgar) [1 fen]. Cut the herbs, add three sheng of water, boil to obtain one sheng, strain. Drink one zhan warm at a time, repeat after a meal interval, and cover warmly. For poisoning, treatment should induce sweating or vomiting; recovery follows emission. If vomiting does not occur, administer again.
To treat Yin Poison, use Fanyin Dan (Reverse-Yin Pill).
Huangqi (Sulfur) [5 liang, ground to powder], Taiyin Xuanjingshi (Mineral Selenite, saline taste, ground to powder), Xiaoshi (Natrii Nitras, ground to powder) [each 2 liang]. First, line an iron pan with half of the Xuanjingshi, then half of the Xiaoshi. Place the Huangqi in the middle, cover with the remaining Xiaoshi, and finally cover entirely with the remaining Xuanjingshi. Seal tightly with a bowl. Burn with charcoal weighing three jin until properly calcined, avoiding excessive smoke. Remove promptly. Cover with a clay pot placed on the ground, surround with ash to prevent smoke escape. Wait until completely cool. Grind finely. Use the center of steamed dough as a binder to form pills the size of pea seeds. Administer fifteen pills with Mugwort Decoction (Aiyetang). For severe cases, increase to twenty to thirty pills. This method is highly effective. For patients with panting and vomiting/regurgitation, relief is immediate upon ingestion. After three to five doses, if no improvement is felt, moxibustion should be applied one and a half cun below the umbilicus. Large moxa cones are required, one hundred burns (zhuang); if unresolved, up to two hundred burns may be used. If extremities are extremely cold, urination is obstructed, the lower abdomen is hard and painful, and the scrotum is retracted, moxibustion must also be applied four cun below the umbilicus as described above. Concurrently, Danggui Sini Tang (Angelica Decoction for Cold Extremities) and Fanyin Dan should be administered frequently to promote internal and external clearance. Delay results in death. Note that Danggui Sini Tang refers to the version modified with Wuzhuyu (Fructus Evodiae) and Shengjiang (Rhizoma Zingiberis Recens). Do not confuse this with ordinary diuretics. This condition is Yin Poison caused by Qi stagnation in the lower abdomen. Some observe urinary retention and apply roasted salt or hot compresses to the lower abdomen to promote urination. However, the cold pathogen in the lower abdomen, when heated, has no outlet and rushes upward to attack the heart, leading to rapid death.
Another formula for treating Yin Poison is Huangqi Wan (Sulfur Pill).
Huangqi (Sulfur) [2 liang], Shuiyin (Hydrargyrum) [1 liang]. Grind together in a pan, sprinkle with a little vinegar, and stir-fry over low heat until faint smoke appears. Remove from fire, sprinkle vinegar again. Repeat this process three to four times. Cool on the ground and grind. Form pills the size of Chinese honeylocust seeds using steamed dough center. Take twenty to thirty pills per dose, swallowed with Mugwort Decoction. Three times daily, before meals.
In Yin Poison syndrome, characterized by a deep, minute pulse nearly imperceptible, cold extremities, extreme restlessness, and unquenchable thirst, use Fuzi Yinzi (Aconite Infusion).
Fuzi (Radix Aconiti Lateralis Preparata) [one piece, weighing more than 0.5 liang, processed, skin and bud removed, divided into four pieces]. Boil in nine sheng of water until reduced to three sheng. Remove the Fuzi. Store in a bottle, seal tightly with oil cloth, and submerge in a well until extremely cold. Take the liquid. Administration of Huangqi Wan concurrently is excellent.
Yin Poison arises from the alteration caused by the cold nature of inappropriate diaphoretic or purgative drugs, typically appearing around the fourth or fifth day; or it forms immediately upon onset due to inherent deficiency and coldness of Yang Qi; or it results from initial exposure to wind-cold or consumption of cold/raw foods. This syndrome is treatable within six days, but untreatable thereafter.