（邵应节）
治气血不足，羸弱周痹，肾虚无子，消渴，淋沥，遗精，崩带，痈疮，痔肿等证（周痹，
周身
交。
何首乌（大者，赤、白各一斤去皮，切片，黑豆拌，九蒸九晒） 白茯苓（乳拌） 牛
膝（
半斤）
此足少阴、厥阴药也。何首乌涩精固气，补肝坚肾，为君；茯苓交心肾而渗脾湿；牛膝
强筋骨而益下焦；当归辛温以养血；枸杞甘寒而补水；菟丝子益三阴而强卫气；补骨脂助命
火而暖丹田；此皆固本之药，使荣卫调适，水火相交，则气血太和，而诸疾自已也（何首乌
流传虽久，服者尚寡，明嘉靖间，方士邵应节进此方，世宗服之，连生皇子，遂盛行于世。
昂按∶地黄、何首乌皆君药也，故六味丸以地黄为君，七宝丹以何首乌为君，各有配合，未
可同类而共施也。即有加减，当各根据本方，随病而施损益。今人多以何首乌加入地黄丸中，
合两方
（杨氏）
治脾肾虚寒，血气羸乏，不思饮食，发热盗汗，遗精白浊，肌体瘦弱，牙齿浮痛等证（肾
为先天之根本，脾为后天之根本，二本有伤，则见上项诸证，故未老而先衰，二本既固，则
自康
熟地黄（二两） 山药 牛膝（酒浸） 枸杞（酒浸，两半） 山茱肉 茯苓（乳拌） 杜
仲（
（酒浸） 肉苁
一方茯苓换茯神，加川续断，名打老儿丸（妇人年过百岁，打其老儿子不肯服此丸）。
此手足少阴、足太阴药也。两肾中间有命火，乃先天之真阳，人之曰用云为，皆此火也
。此
能入
水足
茱、五味生肺液而固精；远志、菖蒲通心气以交肾（遗精白浊，由于心肾不交）；大枣补气
益血，润
丹溪去楮实，更名滋阴大补丸（此阴阳平补之剂，而曰滋阴者，肾为阴脏也）。
[Shao Yingjie's Formula]
Treats conditions such as deficiency of Qi and Blood, emaciation and weakness, generalized arthralgia (Zhou Bi, referring to pain in the limbs caused by invasion of Wind-Cold-Dampness into the whole body's meridians), infertility due to Kidney Deficiency, Xiao Ke (Wasting-Thirst syndrome), dribbling urination, spermatorrhea, leukorrhea and metrorrhagia in women, carbuncles and sores, hemorrhoids, and swelling. (Note: The original text here is fragmented; "Zhou Bi" is followed by "whole body connection," implying blockage of Qi and Blood in the whole body's meridians.)
Ingredients:
He Shou Wu (Polygoni Multiflori Radix Praeparata) (Select large roots, one jin each of red and white varieties, peel, slice, mix with black beans, steam nine times and sun-dry nine times)
Bai Fu Ling (Poria) (Mix with milk and stir-fry)
Niu Xi (Achyranthis Bidentatae Radix) (Half a jin)
This formula consists of herbs belonging to the Foot-Shaoyin Kidney Meridian and Foot-Jueyin Liver Meridian. He Shou Wu astringes essence and consolidates Qi, tonifies the Liver, and strengthens the Kidneys, serving as the Sovereign herb (Jun Yao); Fu Ling facilitates communication between the Heart and Kidneys and leaches out Dampness from the Spleen; Niu Xi strengthens sinews and bones and benefits the Lower Jiao; Dang Gui is pungent and warm to nourish Blood; Gou Qi Zi is sweet and cold to tonify Kidney Water; Tu Si Zi tonifies the Yin of the Liver, Spleen, and Kidney and strengthens Wei Qi (Defensive Qi); Bu Gu Zhi assists Ming Men Fire (Fire of the Gate of Life) and warms the Dan Tian (Elixir Field); these are all herbs that consolidate the root, enabling the harmonious regulation of Ying (Nutritive) and Wei (Defensive) Qi, and the interaction of Water and Fire, thereby achieving Tai He (Great Harmony) of Qi and Blood, causing various diseases to heal spontaneously. (Commentary: Although He Shou Wu has been circulated for a long time, few people take it. During the Jiajing reign of the Ming Dynasty, the alchemist Shao Yingjie presented this formula. Emperor Shizong took it and subsequently had multiple princes born, leading to its widespread popularity. Wang Ang notes: Di Huang and He Shou Wu are both Sovereign herbs. Therefore, Liu Wei Di Huang Wan uses Di Huang as the Sovereign herb, while Qi Bao Mei Ran Dan uses He Shou Wu as the Sovereign herb. Each has its own compatibility principles and should not be simply combined as similar substances. Even with modifications, one should base them on the original formula and adjust according to the disease. Nowadays, many people add He Shou Wu to Di Huang Wan, combining the two formulas...)
[Yang Shi's Formula]
Treats conditions such as Cold-Deficiency of the Spleen and Kidney, deficiency of Qi and Blood, loss of appetite, fever and night sweats, spermatorrhea and turbid urine, emaciation, and floating toothache. (Note: The Kidney is the root of congenital constitution, and the Spleen is the root of acquired constitution. If these two roots are damaged, the aforementioned symptoms appear, leading to premature aging; if these two roots are solidified, health and longevity naturally follow.)
Ingredients:
Shu Di Huang (Rehmanniae Radix Praeparata) (Two liang)
Shan Yao (Dioscoreae Rhizoma)
Niu Xi (Achyranthis Bidentatae Radix) (Soaked in wine)
Gou Qi Zi (Lycii Fructus) (Soaked in wine, 1.5 liang)
Shan Zhu Yu (Corni Fructus)
Fu Ling (Poria) (Mix with milk and stir-fry)
Du Zhong (Eucommiae Cortex)
(Wine-soaked)
Rou Cong Rong (Cistanche Herba)
Another version replaces Fu Ling with Fu Shen (Poria with Hostwood) and adds Chuan Xu Duan (Dipsaci Radix), named Da Lao Er Wan (Legend has it that a woman over a hundred years old beat her old son who refused to take this pill, describing the miraculous nature or origin of the name).
This formula consists of herbs belonging to the Hand-Shaoyin Heart Meridian, Foot-Shaoyin Kidney Meridian, and Foot-Taiyin Spleen Meridian. Between the two kidneys lies the Fire of Ming Men (Gate of Life), which is the True Yang of the congenital constitution. All daily activities and functions of humans rely on this fire.
(The original text here is fragmented, roughly meaning the herbs enter... water suffices...)
Shan Zhu Yu and Wu Wei Zi generate Lung fluid and consolidate essence; Yuan Zhi and Chang Pu (Acori Tatarinowii Rhizoma) unblock Heart Qi to facilitate communication between the Heart and Kidney (Spermatorrhea and turbid urine often result from non-interaction between Heart and Kidney); Da Zao tonifies Qi and nourishes Blood, moistens...
Danxi removed Chu Shi Zi (Broussonetiae Fructus) and renamed it Zi Yin Da Bu Wan (This formula is a balanced tonic for both Yin and Yang, but is called "Nourishing Yin" because the Kidney is a Yin organ).