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Diseases caused by Fire pathogen are extremely harmful, their manifestations are obvious, and death can occur violently. Why? Because Fire can scorch and burn, fly and move wildly, melt and destroy all things, surpassing nothing else in its power, traveling through the pathways of deficiency and excess in the San Jiao (Triple Burner). Therefore, any movement belongs to the transformation of Fire; Fire does not move recklessly but arises upon contact. Humans exist within the intersection of Qi, moving more and resting less; is it possible to avoid triggering Fire? Once Fire moves recklessly, Yuan Qi (Original Qi) is further injured, reaching the extreme of movement, thus becoming incompatible with Yuan Qi. The Classics state: "One water cannot overcome two Fires," which originates from natural creation. These refer to Jun Fire (Monarch Fire) and Ren Fire (Human Fire), as well as Xiang Fire (Minister Fire), Long Fire (Dragon Fire), and Lei Fire (Thunder Fire). The Classics' statement that "One water cannot overcome five Fires" stems from human factors. Great anger causes Fire to arise in the Liver; drunkenness and overeating cause Fire to arise in the Stomach; sexual exhaustion causes Fire to arise in the Kidneys; sorrow and emotional disturbance cause Fire to arise in the Lungs; the Heart, being the Monarch, burns itself to death—these are the Five Emotions' Jue Yang Fire (Rebellious Yang Fire). Furthermore, examining the Nineteen Pathogenesis Patterns in the *Nei Jing* (Inner Canon), five belong to Fire, indicating that Heat-Fire diseases are numerous. However, the Five Emotions' Fire is detailed by Hejian (Liu Wansu); the distinction between Jun and Xiang Fire was clarified by Danxi (Zhu Zhenheng), leaving no gaps in meaning! In terms of clinical manifestations, upper symptoms include wheezing, vomiting, acid regurgitation, hematemesis, epistaxis, rebellious Qi causing distension, dizziness and confusion, throat obstruction, and tinnitus; lower symptoms include sudden diarrhea with tenesmus, lower bleeding, hematuria, dysuria, constipation, cholera with muscle cramps; or external signs such as sores, swellings, carbuncles, chills and fever, restlessness, mania, and wild behavior; or internal signs such as weeping, delirium, palpitations, fright, bone-steaming cough. Various Fire pathogens are too numerous to list. Regarding pulse diagnosis: floating and rapid/hurrying indicates Deficient Fire; deep and full/large indicates Excess Fire. Appearing at both Cun (Inch) positions indicates Upper Jiao Fire, involving the Heart and Lungs; appearing at both Guan (Bar) positions indicates Middle Jiao Fire, involving the Spleen, Stomach, Liver, and Gallbladder; appearing at both Chi (Cubit) positions indicates Lower Jiao Fire, involving the Kidneys and Bladder. Slippery and rapid, forceful upon light and heavy pressure, indicates True Fire; floating but empty upon heavy pressure indicates False Fire. Regarding pharmacological treatment: Jun Fire can be subdued via meridian techniques, extinguished by water, or directly reduced; herbs like Huanglian (Coptidis Rhizoma) can control it. Xiang Fire cannot be reduced by water alone; one should follow its nature to subdue it; only herbs like Huangbai (Phellodendri Cortex) can descend it. However, Huanglian drains Heart Fire, Huangqin (Scutellariae Radix) drains Lung Fire, Shaoyao (Paeoniae Radix) drains Spleen Fire, Chaihu (Bupleuri Radix) drains Liver Fire, and Zhimu (Anemarrhenae Rhizoma) drains Kidney Fire; these are all bitter-cold substances capable of draining tangible Fire. If Fire arises from dietary irregularities and fatigue injuring Yuan Qi, sweet-warm formulas should be used to eliminate it. If Yang is hyperactive and Yin is weak, burning blood fluids, sweet-cold formulas should be used to descend it, such as Dongdong (Ophiopogonis Radix) and Dihuang (Rehmanniae Radix). If Left Kidney True Yin is lost and Fire blazes, Dihuang (Rehmanniae Radix) and Yuanshen (Scrophulariae Radix) can strengthen Water to control Yang. If Right Kidney Mingmen (Gate of Life) is weak and Fire declines, Guizhi (Cinnamomi Ramulus) and Fuzi (Aconiti Lateralis Radix Praeparata) can dissipate Yin and benefit Fire. If Stomach deficiency leads to excessive consumption of cold foods, suppressing Yang Qi within Spleen Earth, Shengma (Cimicifugae Rhizoma) and Gegen (Puerariae Lobatae Radix) can ascend and disperse constrained Fire. Failure to understand these categories when treating Fire diseases inevitably leads to errors of reinforcing Excess and depleting Deficiency.