论曰夫中水毒，其名有三，中水中溪中洒，其状恶寒头痛目疼，心烦懊闷，四肢振 ，
腰背骨节皆强，或 发热，神昏喜睡，朝轻暮剧，手足指冷，二三日则生虫，下部生疮，
不痒不痛，人罕自觉苦，不即治则便脓，虫毒上食五脏，热盛烦毒注下，不过八九日死，若
手足指冷至一寸为微，至肘膝为剧，然治水毒，有阴有阳，其疮正赤如截肉者，阳毒也，其
脉缓大而数，其疮如鲤鱼齿者。阴毒也，其脉沉细而迟，阳毒虽急而易治，法宜发汗，阴毒
虽缓而难治，尤不可忽，凡水毒惟山高及山峡溪源缭绕处，多有之。何者山高水冷，日中始
，得阳气，故阴气常积而水有毒，亦犹广南山高地下，气不疏通，故郁而为瘴，水毒为多阴
，瘴气为多阳，多阳则热结于中，多阴则指节逆冷，二者为病，大体与伤寒相类，欲辨水毒
，即以热汤数斗，蒜四升捣碎，内汤中，去滓洗浴，若身体发赤斑者，是水毒也，此证剧则
为洞利，及齿间出血，心腹烦满，下血如烂肝，不食而狂，皆热毒变化而成也，土人辟却之
法，略与射工相似。
治中水毒，手足指至肘膝下冷，茱萸汤方
吴茱萸（汤洗焙干五两） 乌梅（半两） 犀角屑 升麻 陈橘皮（汤浸去白焙各二两）
上五味，粗捣筛，每服五钱匕，生姜二枣大拍破，水一盏半，煎至八分，去滓空腹温服
，日三夜一。
治中水毒，手足指俱冷，乌梅汤方
乌梅（三两去核熬）
上一味，捣碎，每服三钱匕，水一盏，煎至七分，去滓不拘时频服。
治中水毒，手足指冷至肘膝，水萍散方
水萍（不拘多少）
上一味，曝干，捣罗为散，每服二钱匕，米饮调下，早晨日午近晚各一服。
治中水毒寒热，升麻汤方
升麻（三两） 龙胆 葳蕤 大青（各一两）
上四味，粗捣筛，每服五钱匕，水一盏半，煎至八分，去滓温服，未瘥频服。
治中水毒寒热，水蓼酒方
水蓼（不拘多少）
上一味，捣取汁，每服一合，酒半盏，调匀服，日三。
治中水毒，桃叶饮方
新桃叶（不拘多少）
上一味，旋捣取汁，每服一盏，饮之不拘时候。
治中水毒，苍耳汁方
苍耳（不拘多少）
上一味，捣取汁，以绵沾汁导下部，日三。
治中水毒，桃梅饮方
新桃叶 新梅叶（各半斤）
上二味，洗捣取汁，每服半盏，饮之不拘时。
治中水毒溪毒。寒热如伤寒状。五加皮散方
五加皮（三两洗切）
上一味，捣罗为散，每服一钱匕，酒一盏、调下。日二夜一，粥饮调亦得。
治中水毒溪毒，如伤寒状，葱白汤方
葱白（一握切） 豉（半升） 葛根（二两） 升麻（三分）
上四味，锉如麻豆大，每服四钱匕，水二盏，煎至一盏，去滓温服，移时又服。
治中水毒溪毒，下部虫蚀生疮，牡丹皮散方
牡丹皮（二两）
上一味，捣罗为散，每服二钱匕，酒一盏调下、日三。
治中水毒溪毒，下部虫蚀生疮，葛藤洗方
葛藤（不拘多少）
上一味，以水煮取浓汁，洗下部，并导灌入下部，良。
治中水毒，寒热，蓝根涂方
蓝根并叶（不拘多少）
上一味，洗净捣烂，涂头面及身上，频用为佳。
Discourse states: The condition known as "Zhong Shui Du" (Water Poisoning) has three names, namely Zhong Shui (Poisoning from Water), Zhong Xi (Poisoning from Streams), and Zhong Sa (Poisoning from Sprinkles). Its manifestations include aversion to cold, headache, eye pain, mental restlessness and oppression, tremors of the four limbs, stiffness and rigidity of the lower back, back, and bone joints, occasional fever, lethargy and drowsiness, with symptoms being lighter in the morning and worse in the evening. The tips of the fingers and toes become cold. After two or three days, parasites may develop within the body, and sores may appear in the lower region (genitals or anus), which are neither itchy nor painful. Patients rarely feel significant discomfort initially. If not treated promptly, pus will form. The parasite toxin ascends to erode the five Zang organs, while excessive heat and toxic fire descend. Death may occur within eight or nine days. If coldness extends one cun up from the finger/toe tips, it is mild; if it reaches the elbows and knees, it is severe. However, treating water poisoning involves distinguishing between Yin and Yang patterns. Sores that are bright red like cut flesh indicate Yang Toxicity (Yang Du), characterized by a slow, large, and rapid pulse. Sores resembling carp teeth indicate Yin Toxicity (Yin Du), characterized by a deep, thin, and slow pulse. Although Yang toxicity is acute, it is easier to treat, and the method should involve inducing sweating. Although Yin toxicity progresses slowly, it is difficult to treat and must not be neglected. Generally, water poisoning is common in areas with high mountains and winding stream sources in mountain gorges. Why? Because high mountains have cold water, receiving yang qi only at noon, causing yin qi to accumulate and the water to become toxic. This is similar to the southern regions where high mountains and low ground prevent qi circulation, leading to stagnation and miasma formation. Water poisoning is predominantly yin, while miasma is predominantly yang. Excess yang leads to heat accumulation in the center, while excess yin causes reverse coldness in the finger and toe joints. These two diseases are generally similar to Shang Han (Cold Damage Syndrome). To differentiate water poisoning, use several dou of hot water, add four sheng of crushed garlic, remove the dregs, and bathe. If red spots appear on the body, it is water poisoning. Severe cases may result in torrential diarrhea, bleeding from the gums, abdominal fullness and irritability, passage of blood resembling rotten liver, anorexia, and mania, all resulting from the transformation of heat toxins. The local methods for prevention are similar to those for avoiding She Gong (a type of aquatic poisonous insect).
Formula for treating Zhong Shui Du with coldness extending from finger/toe tips to below elbows and knees: Zhuyu Tang (Evodia Decoction)
Wuzhuyu (Evodiae Fructus, washed with decoction, dried, 5 liang), Wumei (Mume Fructus, 0.5 liang), Xijiao (Rhinocerotis Cornu - *Note: Modern substitute often used*), Shengma (Cimicifugae Rhizoma), Chenjupi (Citri Reticulatae Pericarpium, soaked in decoction, white part removed, dried, each 2 liang).
The above five herbs are coarsely crushed and sifted. Take 5 qianbi per dose, with ginger pieces the size of two dates (crushed), 1.5 zhan of water, decoct until 0.8 zhan remains, strain, and take warm on an empty stomach. Administer three times daily and once at night.
Formula for treating Zhong Shui Du with coldness in all finger/toe tips: Wumei Tang (Mume Decoction)
Wumei (Mume Fructus, 3 liang, pitted and roasted).
The above single herb is crushed. Take 3 qianbi per dose, with 1 zhan of water, decoct until 0.7 zhan remains, strain, and take frequently without time restriction.
Formula for treating Zhong Shui Du with coldness extending from finger/toe tips to elbows and knees: Shuiping San (Lemna Powder)
Shuiping (Lemna minor, amount unspecified).
The above single herb is sun-dried, crushed, and sieved into powder. Take 2 qianbi per dose, mixed with rice drink. Administer once in the morning, at noon, and in the late afternoon.
Formula for treating Zhong Shui Du with alternating chills and fever: Shengma Tang (Cimicifuga Decoction)
Shengma (Cimicifugae Rhizoma, 3 liang), Longdan (Gentianae Radix), Weirui (Polygonati Odorati Rhizoma), Daqing (Isatidis Folium, each 1 liang).
The above four herbs are coarsely crushed and sifted. Take 5 qianbi per dose, with 1.5 zhan of water, decoct until 0.8 zhan remains, strain, and take warm. Repeat frequently if not cured.
Formula for treating Zhong Shui Du with alternating chills and fever: Shuiliao Jiu (Polygonum Hydropiper Wine)
Shuiliao (Polygoni Hydropiperis Herba, amount unspecified).
The above single herb is crushed to extract juice. Take 1 he per dose, mixed with 0.5 zhan of wine. Administer three times daily.
Formula for treating Zhong Shui Du: Tao Ye Yin (Peach Leaf Drink)
Xin Tao Ye (Fresh Peach Leaves, amount unspecified).
The above single herb is freshly crushed to extract juice. Take 1 zhan per dose, drink freely without time restriction.
Formula for treating Zhong Shui Du: Cang Er Zhi Fang (Xanthium Juice Method)
Canger (Xanthii Fructus, amount unspecified).
The above single herb is crushed to extract juice. Apply using cotton soaked in the juice to the lower region (vaginal or anal canal). Administer three times daily.
Formula for treating Zhong Shui Du: Tao Mei Yin (Peach and Plum Leaf Drink)
Xin Tao Ye (Fresh Peach Leaves), Xin Mei Ye (Fresh Plum Leaves, each 0.5 jin).
The above two herbs are washed and crushed to extract juice. Take 0.5 zhan per dose, drink freely without time restriction.
Formula for treating Zhong Shui Du and Xi Du (Stream Poisoning) with chills and fever resembling Shang Han: Wujia Pi San (Acanthopanacis Cortex Powder)
Wujia Pi (Acanthopanacis Cortex, 3 liang, washed and sliced).
The above single herb is crushed and sieved into powder. Take 1 qianbi per dose, mixed with 1 zhan of wine. Administer twice daily and once at night. Mixing with congee drink is also acceptable.
Formula for treating Zhong Shui Du and Xi Du resembling Shang Han: Congbai Tang (Scallion White Decoction)
Congbai (Allii Fistulosi Bulbus, one handful, sliced), Chi (Perillae Fructus/Sojae Semen Praeparatum, 0.5 sheng), Gegen (Puerariae Radix, 2 liang), Shengma (Cimicifugae Rhizoma, 3 fen).
The above four herbs are cut into sizes resembling hemp seeds. Take 4 qianbi per dose, with 2 zhan of water, decoct until 1 zhan remains, strain, and take warm. Re-administer after some time.
Formula for treating Zhong Shui Du and Xi Du with parasitic erosion and sores in the lower region: Mudan Pi San (Moutan Powder)
Mudan Pi (Moutan Cortex, 2 liang).
The above single herb is crushed and sieved into powder. Take 2 qianbi per dose, mixed with 1 zhan of wine. Administer three times daily.
Formula for treating Zhong Shui Du and Xi Du with parasitic erosion and sores in the lower region: Gengteng Wash (Kudzu Vine Wash)
Gengteng (Puerariae Caulis, amount unspecified).
The above single herb is boiled in water to obtain a concentrated decoction. Wash the lower region and irrigate internally. This is effective.
Formula for treating Zhong Shui Du with chills and fever: Lan Gen Tu (Isatis Root Application)
Lan Gen bing ye (Isatidis Radix et Folium, amount unspecified).
The above single herb is washed, crushed, and applied to the head, face, and body. Frequent application is preferred.