论曰四肢者诸阳之本也，阳气内盛，则卫外而为固，乃能充灌于四末，劳伤之人，阳气
虚损，阴气乘之，不能温养四肢，故手足为之逆厥。
治虚劳短气，胸胁苦满，唇口干燥，手足逆冷，或有烦躁，目视 ，腹内时痛。不思
饮食，安神保精，紫芝丸方
紫芝（一两半） 山芋 天雄（炮裂去皮脐） 柏子仁（炒香别研） 枳实（去瓤麸炒
黄） 巴
戟天（去心） 白茯苓（去黑皮各一分半） 人参 生干地黄（洗焙） 麦门冬（去心焙） 五
味子
（去茎叶炒） 半夏（汤洗去滑炒） 牡丹皮 附子（炮裂去脐皮各三分） 蓼实 远志（去
心各
一分） 泽泻 瓜子仁（炒香各半两）
上一十八味，捣罗为末，炼蜜和丸，如梧桐子大，每服十五丸，温酒下，空心日午夜卧
各一服，渐增至三十丸。
治虚劳手足彻冷，精气衰少，骨节疼痛，或时烦热，阴痿不起，久服令人骨体丰盛，肤
色光泽，茯苓丸方
白茯苓（去黑皮三分） 牡荆实（半分） 天门冬（去心焙） 肉苁蓉（酒浸去皴皮炙
干） 牡
蒙山芋 巴戟天（去心） 石长生（去土） 菟丝子（酒浸一宿蒸过别捣） 桂（去粗皮）
杜仲
（去粗皮酥炙） 牡蛎（熬） 吴茱萸（汤浸炒干） 熟干地黄（洗焙干） 泽泻 石槲（去
根及稍
黑者） 附子（炮裂去皮脐） 天雄（炮裂去皮脐） 人参（各一分）
上一十九味，捣罗为末，炼蜜和丸，如梧桐子大，每服二十丸，温酒下，食前夜卧各一
治虚劳阳气不足，四肢逆冷，虚羸少气，补虚益气，黄 丸方
黄 （锉一两） 熟干地黄（焙二两） 石槲（去根） 五味子（炒） 白术 枸杞子 肉
苁蓉
（酒浸一宿去皴皮焙） 山芋 桂（去粗皮） 人参 甘草（炙锉各一两半）
上一十一味，捣罗为末，炼蜜和丸，如梧桐子大，每服二十丸，温酒下，日二，稍加至
三十丸，饮下亦得。
治虚劳两足疼冷，或时发热。由于行房失度，两目 ，四肢沉重，多卧少起，鹿茸丸
方
鹿茸（酒浸炙黄） 桂（去粗皮） 石膏（碎各三分） 熟干地黄（洗焙） 续断 牛
膝（酒浸
一宿锉焙各一两） 肉苁蓉（酒洗切焙） 干姜（炮各半两） 杜仲（去粗皮酥炙二两） 菟
丝子
（酒浸别捣） 荆子 五味子（炒） 人参 巴戟天（去心） 远志（去心） 蛇床子（炒
香） 石槲
（去根及黑者） 枸杞子（各一两）
上一十八味，捣罗为末，炼蜜丸如梧桐子大，每服十五丸，空腹食前夜卧，温酒下。渐
加至二十丸，亦可为散，酒服一钱匕。
治虚劳不足。手多冷，补虚益气，钟乳散方
钟乳（研半两） 防风（去叉） 人参（各一分） 细辛（去苗叶半分） 桂（去粗皮）
干姜（
炮各一钱）
上六味，捣罗为散，分作五贴，每旦温酒调服一贴。服讫饮食冷热饥饱，皆令适中，时
饮少酒，常令醺醺，若热烦，以冷水洗手面。
治虚劳，两足厥冷，夜多盗汗，身体多寒，骨节沉重，精神不守，恶闻人声，梦寐失精，
吃食减少，大便不调，昏困多睡。菟丝子丸方
菟丝子（酒浸别捣末半两） 五味子 鳖甲（去裙 醋炙） 熟干地黄（焙） 芎 天
灵盖
（酥炙） 桂（去粗皮） 防风（去叉） 牡蛎（熬） 黄 （锉炒各一分） 附子（炮裂
去皮脐） 石
槲（去根） 山茱萸 白茯苓（去黑皮） 萆 （各半两） 牛膝（酒浸一宿切焙一两）
上一十六味，捣罗为细末，炼蜜丸如梧桐子大，每服三十丸，空心，入盐少许，煎茯苓
汤下。
治虚劳久病，真气欲绝，喘满自汗，四肢厥逆，面色青白，全不入食，续命丸方
楮实（四两） 附子（炮裂去皮脐） 桂（去粗皮各一两） 牛膝（酒浸一宿切焙一两
半） 蜀
椒（去目并合口者炒出汗二两）
上五味，捣罗为末，炼蜜和丸，如梧桐子大，每服二十丸，温酒或盐汤下，空心食前服
治五劳手足逆冷，肌体羸瘦，面干少色，四肢拘急，不思饮食，及阴毒伤寒，四肢厥冷，
面青自汗，妇人血脏虚冷，伤中带下，男子膀胱小肠寒疝气痛，或小便频数，淋沥不禁，及
久患滑泄泻痢，悉治之，内固丸方
硫黄（研） 乌头（水浸三日切以盐炒黄去盐不用） 青橘皮（去白炒） 香子（盐
炒各二
两） 楝实（锉炒一分）
上五味，捣罗为末，酒煮面糊，丸如梧桐子大，雄黄研细为衣，每服七丸至十丸，盐汤
或温酒下，空心食前服。
治虚劳手足逆冷，脚膝疼痛，补虚黄 浸酒方
黄 （去芦头二两） 萆 防风（去叉） 芎 牛膝（去苗各一两半） 独活（去
芦头）
山茱萸（各一两） 五味子（二两）
上八味细锉，用生绢袋子贮之，以好酒二斗浸，秋冬五日，春夏三日，每日空腹温服
半盏。
治丈夫五劳七伤，小便数，饶虚汗，足膝冷疼，不能久立，健忘昏塞，精神不爽。山芋
苁蓉丸方
山芋 肉苁蓉（酒浸切焙） 牛膝（酒浸切焙） 菟丝子（酒浸捣焙） 五味子 杜仲
（去粗
皮炙锉） 泽泻熟干地黄（焙） 茯神（去木） 人参 山茱萸 桂（去粗皮） 巴戟天（去
心）
石槲（去根） 鹿茸（去毛酥炙） 蛇床子 远志（去心） 续断 覆盆子 天雄（炮裂去
皮脐）
甘草（炙锉等分）
上二十一味，捣罗为末，炼蜜和丸，如梧桐子大，每服三十丸，温酒下，空心食前、日
再服，一方为散，酒调下二钱匕。
治五劳七伤，髓液虚惫，四肢逆冷，黄 丸方
黄 （锉） 肉苁蓉（酒浸切焙） 五味子 天雄（炮裂去皮脐） 牛膝（酒浸切焙各
二两）
熟干地黄（三两） 干姜（炮） 山芋 山茱萸 桂（去粗皮各一两半）
上一十味，捣罗为末，炼蜜和丸，如梧桐子大，每服三十丸，食前酒下。
It is discussed that the four limbs are the root of all Yang meridians. When Yang Qi is abundant internally, it guards the exterior and maintains solidity, thereby being able to fill and irrigate the extremities. In individuals suffering from labor injury, Yang Qi is deficient and damaged, allowing Yin Qi to take advantage and invade; unable to warm and nourish the four limbs, the hands and feet become cold and inverted (cold extremities).
Zizhi Wan Formula for treating deficiency exhaustion with shortness of breath, distressing fullness in the chest and hypochondrium, dryness of lips and mouth, cold extremities, possibly accompanied by irritability, blurred vision, occasional abdominal pain, and loss of appetite, to calm the mind and preserve essence:
Ganoderma lucidum (1 liang 5 qian), Dioscorea opposita (Shanyu), Aconitum carmichaelii praeparatum (Tianxiong, prepared, cracked, skin and umbilicus removed), Biota seed (Baiziren, fried until fragrant, ground separately), Immature bitter orange (Zhishi, pith removed, fried with bran until yellow), Morinda officinalis (Bajitian, heart removed), Poria cocos (Baifuling, black skin removed, each 1 fen 5 qian), Ginseng (Renshen), Fresh dried Rehmannia root (Shenggan Dihuang, washed and dried), Ophiopogon tuber (Mendong, heart removed and dried), Schisandra fruit (Wuweizi, stems and leaves removed, fried), Pinellia tuber (Banxia, washed with decoction to remove slipperiness, fried), Moutan bark (Mudanpi), Aconitum lateralare praeparatum (Fuzi, prepared, cracked, umbilicus and skin removed, each 3 qian), Polygonum multiflorum seeds (Liaoshi), Polygala root (Yuanzhi, heart removed, each 1 fen), Alisma rhizome (Zexie), Melon seeds (Gua Zi Ren, fried until fragrant, each 0.5 liang).
The above eighteen herbs are crushed, sifted into powder, mixed with refined honey to form pills the size of Sophora japonica seeds. Take fifteen pills per dose, administered with warm wine. Doses are taken on an empty stomach, at midnight, and before sleep, gradually increasing to thirty pills.
Fuling Wan Formula for treating deficiency exhaustion causing thorough coldness of hands and feet, depletion of essence and qi, joint pain, occasional feverish sensation, impotence, and long-term use leads to robust bone and body structure with lustrous skin and complexion:
Poria cocos (Baifuling, black skin removed, 3 qian), Vitex fruit (Mujingshi, 0.5 fen), Asparagus tuber (Tianmendong, heart removed and dried), Cistanche stem (Roucongrong, soaked in wine, wrinkled skin removed, roasted dry), Lithospermum erythrorhizon (Mumeng), Dioscorea opposita (Shanyu), Morinda officinalis (Bajitian, heart removed), Lithospermum radix (Shichangsheng, soil removed), Cuscuta seed (Tusizi, soaked in wine overnight, steamed, ground separately), Cinnamon twig (Gui, outer bark removed), Eucommia bark (Duzhong, outer bark removed, roasted with su), Oyster shell (Muli, calcined), Evodia fruit (Wuzhuyu, soaked in water, fried dry), Prepared Rehmannia root (Shugan Dihuang, washed and dried), Alisma rhizome (Zexie), Lithospermum radix (Shihu, roots and slightly black parts removed), Aconitum lateralare praeparatum (Fuzi, prepared, cracked, skin and umbilicus removed), Aconitum carmichaelii praeparatum (Tianxiong, prepared, cracked, skin and umbilicus removed), Ginseng (Renshen, each 1 fen).
The above nineteen herbs are crushed, sifted into powder, mixed with refined honey to form pills the size of Sophora japonica seeds. Take twenty pills per dose, administered with warm wine, before meals and before sleep.
Huangqi Wan Formula for treating deficiency exhaustion due to insufficient Yang Qi, cold extremities, emaciation with shortness of breath, possessing effects of tonifying deficiency and benefiting qi:
Astragalus root (Huangqi, cut 1 liang), Prepared Rehmannia root (Shugan Dihuang, dried 2 liang), Lithospermum radix (Shihu, roots removed), Schisandra fruit (Wuweizi, fried), Atractylodes macrocephala (Baizhu), Goji berry (Gouqizi), Cistanche stem (Roucongrong, soaked in wine overnight, wrinkled skin removed, dried), Dioscorea opposita (Shanyu), Cinnamon twig (Gui, outer bark removed), Ginseng (Renshen), Licorice root (Gancao, roasted and cut, each 1 liang 5 qian).
The above eleven herbs are crushed, sifted into powder, mixed with refined honey to form pills the size of Sophora japonica seeds. Take twenty pills per dose, administered with warm wine, twice daily, gradually increasing to thirty pills. Administration with water is also acceptable.
Lurong Wan Formula for treating deficiency exhaustion causing painful coldness in both legs, occasional fever, resulting from excessive sexual activity, leading to blurred vision, heavy limbs, tendency to lie down rather than rise:
Deer antler velvet (Lurong, soaked in wine, roasted until yellow), Cinnamon twig (Gui, outer bark removed), Gypsum fibrosum (Shigao, crushed, each 3 qian), Prepared Rehmannia root (Shugan Dihuang, washed and dried), Dipsacus root (Xuduan), Achyranthes root (Niuxi, soaked in wine overnight, cut and dried, each 1 liang), Cistanche stem (Roucongrong, washed in wine, sliced and dried), Dried ginger (Ganjiang, prepared, each 0.5 liang), Eucommia bark (Duzhong, outer bark removed, roasted with su, 2 liang), Cuscuta seed (Tusizi, soaked in wine, ground separately), Tribulus fruit (Jingzi), Schisandra fruit (Wuweizi, fried), Ginseng (Renshen), Morinda officinalis (Bajitian, heart removed), Polygala root (Yuanzhi, heart removed), Cnidium fruit (Shechuangzi, fried until fragrant), Lithospermum radix (Shihu, roots and black parts removed), Goji berry (Gouqizi, each 1 liang).
The above eighteen herbs are crushed, sifted into powder, mixed with refined honey to form pills the size of Sophora japonica seeds. Take fifteen pills per dose, on an empty stomach, before meals, and before sleep, administered with warm wine. Gradually increase to twenty pills. It may also be made into a powder, taking one qian bi with wine.
Zhongru San Formula for treating deficiency exhaustion insufficiency, frequent coldness of hands, possessing effects of tonifying deficiency and benefiting qi:
Calcite (Zhongru, ground, 0.5 liang), Saposhnikovia root (Fangfeng, forked branches removed), Ginseng (Renshen, each 1 fen), Asarum root (Xixin, seedlings and leaves removed, 0.5 fen), Cinnamon twig (Gui, outer bark removed), Dried ginger (Ganjiang, prepared, each 1 qian).
The above six herbs are crushed, sifted into powder, divided into five doses. Each morning, mix one dose with warm wine for administration. After taking the medicine, diet temperature and satiety should be moderate. Drink small amounts of wine occasionally to maintain a slight buzz. If heat and irritability occur, wash hands and face with cold water.
Tusizi Wan Formula for treating deficiency exhaustion with cold inversion of both feet, night sweats, general body coldness, heavy joints, unsettled spirit, aversion to human voices, nocturnal seminal emission, reduced appetite, irregular bowel movements, drowsiness, and excessive sleep:
Cuscuta seed (Tusizi, soaked in wine, ground into powder, 0.5 liang), Schisandra fruit (Wuweizi), Turtle plastron (Biejia, skirt removed, vinegar-roasted), Prepared Rehmannia root (Shugan Dihuang, dried), Ligusticum chuanxiong (Chuanxiong), Tianlinggai (Roasted with su), Cinnamon twig (Gui, outer bark removed), Saposhnikovia root (Fangfeng, forked branches removed), Oyster shell (Muli, calcined), Astragalus root (Huangqi, cut and fried, each 1 fen), Aconitum lateralare praeparatum (Fuzi, prepared, cracked, skin and umbilicus removed), Lithospermum radix (Shihu, roots removed), Cornus fruit (Shanzhuyu), Poria cocos (Baifuling, black skin removed), Dioscorea hypoglauca (Bixie, each 0.5 liang), Achyranthes root (Niuxi, soaked in wine overnight, cut and dried, 1 liang).
The above sixteen herbs are crushed, sifted into fine powder, mixed with refined honey to form pills the size of Sophora japonica seeds. Take thirty pills per dose, on an empty stomach, with a little salt, administered with decoction of Poria cocos (Fuling Tang).
Xuming Wan Formula for treating prolonged deficiency exhaustion where true Qi is about to perish, panting and fullness, spontaneous sweating, cold extremities, cyanotic and pale complexion, complete inability to eat:
Broussonetia fruit (Chushi, 4 liang), Aconitum lateralare praeparatum (Fuzi, prepared, cracked, skin and umbilicus removed), Cinnamon twig (Gui, outer bark removed, each 1 liang), Achyranthes root (Niuxi, soaked in wine overnight, cut and dried, 1.5 liang), Sichuan pepper (Shujiao, eyes and closed-mouth ones removed, fried until sweat appears, 2 liang).
The above five herbs are crushed, sifted into powder, mixed with refined honey to form pills the size of Sophora japonica seeds. Take twenty pills per dose, administered with warm wine or salt water, on an empty stomach and before meals.
Neigu Wan Formula for treating five labors causing cold inversion of hands and feet, emaciated body, dry face lacking color, limb stiffness and spasms, loss of appetite, as well as Yin-toxin Cold Damage causing cold extremities, cyanotic face, and spontaneous sweating; for women with blood organ deficiency-cold and leukorrhea; for men with cold hernia pain in bladder and small intestine, frequent urination, dribbling incontinence, and chronic slippery diarrhea/dysentery:
Sulfur (Liuhuang, ground), Aconitum carmichaelii (Wutou, soaked in water for three days, sliced, fried with salt until yellow, salt discarded), Green tangerine peel (Qingjupi, white pith removed, fried), Amomum fruit (Xiangzi, fried with salt, each 2 liang), Chinaberry fruit (Lianshi, cut and fried, 1 fen).
The above five herbs are crushed, sifted into powder, cooked with wine and wheat paste to form pills the size of Sophora japonica seeds. Coated with finely ground Realgar (Xionghuang). Take seven to ten pills per dose, administered with salt water or warm wine, on an empty stomach and before meals.
Huangqi Infused Wine Formula for treating deficiency exhaustion causing cold inversion of hands and feet, foot and knee pain, possessing effects of tonifying deficiency:
Astragalus root (Huangqi, removed rhizome head, 2 liang), Dioscorea hypoglauca (Bixie), Saposhnikovia root (Fangfeng, forked branches removed), Ligusticum chuanxiong (Chuanxiong), Achyranthes root (Niuxi, removed seedlings, each 1.5 liang), Angelica pubescens (Duhuo, removed rhizome head), Cornus fruit (Shanzhuyu, each 1 liang), Schisandra fruit (Wuweizi, 2 liang).
The above eight herbs are finely cut, stored in a raw silk bag, and soaked in two dou of good wine. Soak for five days in autumn/winter, three days in spring/summer. Take half a zhan warm on an empty stomach daily.
Shanyu Rongrong Wan Formula for treating men with five labors and seven injuries, frequent urination, profuse spontaneous sweating, cold and painful feet and knees, inability to stand for long periods, forgetfulness, mental cloudiness, and poor spirit:
Dioscorea opposita (Shanyu), Cistanche stem (Roucongrong, soaked in wine, sliced and dried), Achyranthes root (Niuxi, soaked in wine, sliced and dried), Cuscuta seed (Tusizi, soaked in wine, ground and dried), Schisandra fruit (Wuweizi), Eucommia bark (Duzhong, outer bark removed, roasted and cut), Alisma rhizome (Zexiu), Prepared Rehmannia root (Shugan Dihuang, dried), Poria cocos with hostwood (Fushen, wood removed), Ginseng (Renshen), Cornus fruit (Shanzhuyu), Cinnamon twig (Gui, outer bark removed), Morinda officinalis (Bajitian, heart removed), Lithospermum radix (Shihu, roots removed), Deer antler velvet (Lurong, hair removed, roasted with su), Cnidium fruit (Shechuangzi), Polygala root (Yuanzhi, heart removed), Dipsacus root (Xuduan), Raspberry (Fupenzi), Aconitum carmichaelii praeparatum (Tianxiong, prepared, cracked, skin and umbilicus removed), Licorice root (Gancao, roasted and cut, equal parts).
The above twenty-one herbs are crushed, sifted into powder, mixed with refined honey to form pills the size of Sophora japonica seeds. Take thirty pills per dose, administered with warm wine, on an empty stomach and before meals, twice daily. Alternatively, make into a powder, take two qian bi mixed with wine.
Huangqi Wan Formula for treating five labors and seven injuries, deficiency and exhaustion of marrow and fluids, cold extremities:
Astragalus root (Huangqi, cut), Cistanche stem (Roucongrong, soaked in wine, sliced and dried), Schisandra fruit (Wuweizi), Aconitum carmichaelii praeparatum (Tianxiong, prepared, cracked, skin and umbilicus removed), Achyranthes root (Niuxi, soaked in wine, sliced and dried, each 2 liang), Prepared Rehmannia root (Shugan Dihuang, 3 liang), Dried ginger (Ganjiang, prepared), Dioscorea opposita (Shanyu), Cornus fruit (Shanzhuyu), Cinnamon twig (Gui, outer bark removed, each 1 liang 5 qian).
The above ten herbs are crushed, sifted into powder, mixed with refined honey to form pills the size of Sophora japonica seeds. Take thirty pills per dose, administered with wine before meals.