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For sores that are severely ulcerated and difficult to heal, first wash the affected area with an external medicinal decoction (General Washing Method), then sprinkle Shanlian San (General Formula 73) over it. Internally administer Dongtian Jiuku Dan (General Formula 53), taking three qian per dose, delivered with aged wine. After ingestion, cover the patient to induce sweating. Administer another dose every two days, and yet another after a further two-day interval. During the two-day intervals between doses, take Xingxiao Wan (General Formula 47) once daily. Once the toxic fluid has been completely drained, wait seven more days before administering Xingxiao Wan twice more, followed by Dazao Wan (General Formula 55), taken five qian each morning and evening. Even in the most critical cases, this regimen can yield miraculous results.

When carbuncles or ulcers fail to heal for many years, they inevitably develop "fan hua" (proliferation of tissue resembling cauliflower) and form hard indurations ("ying gang") around the periphery. For treatment, take an old toad, slit its abdomen including internal organs, puncture several holes in the toad's body, and apply it directly over the sore opening. In mild cases, replace the toad once daily; in severe cases, twice daily. On days when the toad is applied, internally administer Xingxiao Wan (General Formula 47), three qian per dose, taken with aged wine to alleviate pain. After three days, when the toxicity is exhausted, administer Xingxiao Wan (General Formula 47) again to resolve the proliferating tissue and soften the hard induration, yielding extraordinary efficacy. If a major abscess has just begun to ulcerate, apply the same method; the toxin will exit through the holes in the toad. If the anal region is hard and the lesion deep, take fresh roots, branches, and leaves of Arctii Fructus (Niu Bang Zi) herb, or tender herbs of Violae Herba (Zi Hua Di Ding), crush them into a paste, and apply it inside the anal canal. Both methods effectively draw out toxins and flatten the induration.

When foul flesh protrudes from an ulcerated cavity, it is termed "du gen" (toxic root). Some practitioners mistakenly use caustic agents to corrode it away, which is an error by incompetent physicians. They fail to realize that a weakened constitution cannot withstand increased pain. Moreover, even if corroded, the tissue often regrows; how can one justify repeated corrosion? In such cases, it is appropriate to apply Ping'an Bing (General Formula 63) and cover it with a plaster, changing it once daily. For mild cases, this lasts two to three days; for severe cases, six to seven days. The lesion becomes non-itchy and painless, and the toxic root falls off naturally. During the application period, internally administer Neituo San (General Formula 28) daily. Once the toxic root has detached, administer Baoyuan Tang (General Formula 28) and Siwu Tang (General Formula 23) to conclude the treatment and promote recovery.