（俗名大头天行。）
时毒者，四时不正之疫气而感于人也。初觉憎寒发热，恍惚不宁，肢体酸痛，或兼咽痛
，次
舌干燥，咽喉不利。常见年岁凶荒，刍荛之人多患之，乃饥饱不时，胃气有损，邪气乘虚而
入，客于心肺之间，上攻为患，宜从轻治，安里为主，兼升散解毒，用普济消毒饮最善。如
不应，则宜砭去恶血，仍投前药即应。更于鼻内搐通关散，取十余嚏即效。若搐药不嚏，及
神
阅诸书治法，凡初起耳项肿痛，状似伤寒，恶寒发热者，人参败毒散微汗之；兼口渴大
便秘
参、桔梗、薄荷、鼠粘子、天花粉，或加酒炒黄连和解之。如已汗下解毒不消，势将作脓，
气弱难溃者，用消毒托里。此皆古人治时毒之法，录备参用。
普济消毒饮
黄连（五钱，酒炒） 黄芩（五钱，酒炒） 橘红（二钱） 元参（二钱） 生甘草（二钱） 人
参（
钱）白僵蚕（七分，炒） 升麻（七分） 柴胡（二钱）
上为细末，半用汤调，时时服之，半用蜜丸噙化之，服尽即愈。或加川芎、当归， 咀
三、五钱，水煎稍热，时时服之。如大便硬，加熟大黄一钱或二钱以利之。
消毒托里散
黄 人参 白术 当归 白芍 川芎 甘草 白芷 金银花 熟地黄（等分量用之）
上水煎，分疮之上下，食之前后，服之。
通关散
细辛（用真者，药店每以马蹄香草乱之。） 薄荷 猪牙皂角
上等分，为极细末，以纸拈少许入鼻内，候得嚏口开，随进汤药。一方，只用二味，无
薄荷。
人参败毒散（通用三）
防风通圣散（通用七）
小柴胡汤（通用十四）
(Also known as "Da Tou Tian Xing" [Big Head Epidemic].)
Shi Du (Seasonal Toxicity) refers to a disease contracted by humans due to the abnormal epidemic qi of the four seasons. Initially, there is aversion to cold accompanied by fever, mental restlessness and confusion, soreness and pain in the limbs, and sometimes accompanied by sore throat. Subsequently, dryness of the tongue and discomfort in the throat occur. It is commonly seen during years of famine, affecting those who gather firewood and grass; this is caused by irregular eating habits damaging the Stomach Qi (Stomach Energy), allowing pathogenic factors to enter through deficiency and lodge between the Heart and Lungs, attacking upwards to cause illness. Treatment should be mild, focusing on stabilizing the interior while simultaneously using ascending, dispersing, and detoxifying methods. Pu Ji Xiao Du Yin (Universal Benefit Detoxification Decoction) is most effective. If there is no response, phlebotomy with a stone needle (Bian Fa) should be used to remove bad blood, followed by administering the previous medication, which will likely yield results. Additionally, Tong Guan San (Passage Opening Powder) can be insufflated into the nose; inducing more than ten sneezes will bring relief. If the medication does not induce sneezing, and... [text gap] ...consulting various books on treatment methods: for cases starting with swelling and pain in the ears and neck, resembling Tai Yang disease (Exterior Syndrome) with aversion to cold and fever, Ren Shen Bai Du San (Ginseng Detoxification Powder) should be used to induce slight sweating. If accompanied by thirst and constipation, add Ren Shen (Ginseng), Jie Geng (Platycodon Root), Bo He (Mint), Niu Bang Zi (Arctium Fruit), Tian Hua Fen (Trichosanthes Root), or add Jiu Chao Huang Lian (Wine-fried Coptis Rhizome) to harmonize. If sweating, purging, and detoxification have failed to resolve the condition, and pus formation is imminent but the patient's Qi is too weak to rupture the abscess, use Xiao Du Tuo Li San (Detoxification and Supporting Interior Powder). These are all ancient methods for treating Shi Du, recorded here for reference.
Pu Ji Xiao Du Yin (Universal Benefit Detoxification Decoction)
Huang Lian (Coptis Rhizome, 5 qian, wine-fried), Huang Qin (Scutellaria Root, 5 qian, wine-fried), Ju Hong (Citrus Reticulata Peel, 2 qian), Xuan Shen (Rehmannia Root Preparata, 2 qian), Sheng Gan Cao (Raw Licorice Root, 2 qian), Ren Shen (Ginseng, ... qian), Bai Jiang Can (Bombyx Batryticatus, 7 fen, fried), Sheng Ma (Cimicifuga Rhizome, 7 fen), Chai Hu (Bupleurum Root, 2 qian).
Grind the above ingredients into a fine powder. Use half mixed with water decoction, taken frequently. Use the other half made into honey pills for sucking/melting in the mouth. Finishing the course leads to recovery. Alternatively, add Chuan Xiong (Ligusticum Rhizome) and Dang Gui (Angelica Sinensis), chop 3-5 qian, decoct in water, drink slightly warm, taken frequently. If stool is hard, add Shu Da Huang (Prepared Rhubarb) 1-2 qian to promote bowel movement.
Xiao Du Tuo Li San (Detoxification and Supporting Interior Powder)
Huang Qi (Astragalus Root), Ren Shen (Ginseng), Bai Zhu (Atractylodes Macrocephala Rhizome), Dang Gui (Angelica Sinensis), Bai Shao (White Peony Root), Chuan Xiong (Ligusticum Rhizome), Gan Cao (Licorice Root), Bai Zhi (Angelica Dahurica Root), Jin Yin Hua (Lonicera Flower), Shu Di Huang (Prepared Rehmannia Root). (Use equal parts).
Decoct in water. Administer before or after meals depending on whether the ulcer is located superiorly or inferiorly.
Tong Guan San (Passage Opening Powder)
Xi Xin (Asarum Root, must be authentic; pharmacies often substitute with Hippocrepis coum/Ma Ti Xiang Cao). Bo He (Mint), Zhu Ya Zao Jiao (Gleditsia Sinensis Fruit Spine).
Equal parts, ground into an extremely fine powder. Take a small amount on a paper twist, insert into the nose. Wait for sneezing and mouth opening, then administer decoction immediately. Another prescription uses only two ingredients, without Mint.
Ren Shen Bai Du San (Ginseng Detoxification Powder) (General Formula No. 3)
Fang Feng Tong Sheng San (Saposhnikovia Unblocking Hero Powder) (General Formula No. 7)
Xiao Chai Hu Tang (Minor Bupleurum Decoction) (General Formula No. 14)