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Medicinals of the Lower Grade, totaling one hundred and twenty-five varieties, serve as Zuo Shi (assistant or guiding medicinals). They primarily treat diseases in correspondence with Earth Qi. Most are toxic and must not be taken for a prolonged period. For eliminating Han Re Xie Qi (cold-heat pathogenic factors), breaking Ji Ju (accumulations and masses), and curing chronic diseases, refer to this Lower Classic.

Duan Shi (Calcined Lime), Fan Shi (Alumen), Qian Dan (Minium), Fen Xi (Lead Powder), Xi Jing Bi (Tin Mirror Nose), Dai Zhe (Hematitum), Rong Yan (Halitum Rubrum), Da Yan (Sal Magnesium), Lu Yan (Halitum), Bai E (Creta Alba), Dong Hui (Winter Ash), Qing Lang Gan (Lapis Lazuli). (The above are Jade and Stone category, eight varieties of Lower Grade. The old version listed twelve varieties.)

Fu Zi (Radix Aconiti Lateralis Preparata), Wu Tou (Radix Aconiti), Tian Xiong (Radix Aconiti Longa), Ban Xia (Rhizoma Pinelliae), Hu Zhang (Rhizoma Arisaematis Cum Bile), Yuan Wei (Rhizoma Belamcandae), Da Huang (Rhei Radix et Rhizoma), Ting Li (Semen Lepidii/Descurainiae), Jie Geng (Platycodi Radix), Lang Dang Zi (Semen Hyoscyami), Cao Hao (Artemisiae Annuae Herba), Xuan Fu Hua (Inulae Flos), Li Lu (Veratri Radix et Rhizoma), Gou Wen (Gelsemii Radix), She Gan (Belamcandae Rhizoma), She He (Ophiopogonis Radix? [Note: Contextual ambiguity in original text, likely referring to a specific plant]), Heng Shan (Dichroae Radix), Shu Qi (Dichroae Radix Praeparata cum Vino), Gan Sui (Kansui Radix), Bai Lian (Ampelopsis Radix), Qing Xiang Zi (Celosiae Semen), Huo Jun (Agaricus), Bai Ji (Bletillae Rhizoma), Da Ji (Euphorbiae Pekinensis Radix), Ze Qi (Euphorbiae Helioscopiae Herba), Yin Yu (Skimmiae Folium), Guan Zhong (Dryopteridis Crassirhizomatis Rhizoma), Rao Hua (Wikstroemiae Indicae Cortex), Ya Zi (Brucea Fructus), Yang Zhi Zhu (Rhododendri Mollis Flos), Shang Lu (Phytolaccae Radix), Yang Ti (Rumex Japonici Radix), Xu (Polygoni Avicularis Herba), Ye Lang Du (Stellerae Radix), Bai Tou Weng (Pulsatillae Radix), Gui Jiu (Podophylli Rhizoma), Yang Tao (Actinidiae Chinensis Radix), Nu Qing (Cynanchi Atrati Radix), Lian Qiao (Forsythiae Fructus), Lv Ru (Asari Herba?), Wu Jiu (Davalliae Rhizoma), Lu Huo (Lespedezae Herba), Zao Xiu (Paridis Rhizoma), Shi Chang Sheng (Sedi Herba), Lu Ying (Sambuci Willamsii Ramulus et Folium), Jin Cao (Leptochloae Herba), Niu Xi (Achyranthis Bidentatae Radix), Xia Ku Cao (Prunellae Spica), Yuan Hua (Genkwa Flos). (The above are Herb category, forty-nine varieties of Lower Grade. The old version listed forty-eight varieties.)

Ba Dou (Crotonis Fructus), Shu Jiao (Zanthoxyli Pericarpium), Zao Jia (Gleditsiae Sinensis Fructus), Liu Hua (Salicis Flos), Lian Shi (Meliae Fructus), Yu Li Ren (Pruni Semen), Mang Cao (Illicii Anisati Fructus? [Note: Mang Cao usually refers to Illicium anisatum or similar toxic plants]), Lei Wan (Omphaliae Lapidea), Tong Ye (Paulowniae Folium), Zi Bai Pi (Catalpae Cortex), Shi Nan (Photiniae Folium), Huang Huan (Sophorae Flavescentis Radix? [Note: Huang Huan is often associated with Sophora flavescens or similar]), Sou Shu (Deutziae Scabrae Ramulus), Shu Li (Rhamni Davuricae Fructus), Yao Shi Gen (Root of Medicinal Fruit), Luan Hua (Koelreuteriae Flos), Man Jiao (Zanthoxyli Caulis). (The above are Wood category, seventeen varieties of Lower Grade. The old version listed eighteen varieties.)

Tun Luan (Testis Suis), Jun Zhi (Adeps Capreoli), Shu (Mus Musculus), Liu Chu Mao Ti Jia (Hair, Hoof, and Nail of Six Domestic Animals). (The above are Beast category, four varieties of Lower Grade. Same as the old version.)

Ha Ma (Bufonis Venenum/Toad), Ma Dao (Concha Mytili/Snail Shell? [Note: Ma Dao often refers to Concha Ostreae or similar in ancient texts, context dependent]), She Tui (Serpentis Periostracum), Qiu Yin (Pheretima), Wu Gong (Scolopendra), Shui Zhi (Hirudo), Ban Miao (Mylabris), Bei Zi (Concha Cypraeae), Shi Can (Lithocolletis Larva), Que Weng (Nidus Vespae), Qiang Lang (Scarabaeus Stercorarius), Lou Gu (Gryllotalpa Africana), Ma Lu (Julus terrestris), Di Dan (Cantharis), Shu Fu (Armadillidium Vulgare), Ying Huo (Luciola), Yi Yu (Lepisma Saccharina). (The above are Insect and Fish category, nineteen varieties of Lower Grade. The old version listed eighteen varieties.)

Tao He Ren (Persicae Semen), Xing He Ren (Armeniacae Semen Amarum). (The above, three varieties of Lower Grade. Same as the old version.)

Fu Bi (Fermented Soybean Residue? [Note: Specific identification varies]). (The above are Rice and Grain category, one variety of Lower Grade. Same as the old version.)

Ku Hu (Lagenariae Fructus Amarus), Shui Jin (Water Plantain? [Note: Text says Shui Jin, likely a variant or specific local name]). (The above are Vegetable category, two varieties of Lower Grade. Same as the old version.)

Bi Zi (One variety, details unclear).

Appendix: Wu Pu Ben Cao (Wu Pu's Materia Medica).