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The Hand-Yangming Large Intestine Meridian has twenty acupoints. Its pathway starts from Shangyang (LI1), passes through Erjian (LI2) and Sanjian (LI3), reaches Hegu (LI4) and Yangxi (LI5), then passes through Pianli (LI6) and Wenliu (LI7), descends near Xialian (LI8), Shanglian (LI9), and Sanli (LI10), traverses the route of Quchi (LI11), Zhouliao (LI12), and Wuli (LI13), ascends to Binao (LI14) and Jianyu (LI15), and finally arrives at Jugu (LI16). Tianding (LI17) curves upward to Futu (LI18); Heliao (LI19) connects to the lips; Yingxiang (LI20) is close to the nose.

Shangyang (LI1) is located on the medial side of the index finger. Erjian (LI2) is sought in the depression before the proximal interphalangeal joint. Sanjian (LI3) is taken in the depression after the proximal interphalangeal joint. Hegu (LI4) is between the divergent bones of the web of the thumb and index finger. Yangxi (LI5) is on the radial side of the wrist crease. Pianli (LI6) is located three cun distal to the wrist crease. Wenliu (LI7) is five cun distal to the wrist crease. Xialian (LI8) is seen five cun proximal to Quchi (LI11). Shanglian (LI9) is three cun proximal to Quchi (LI11). Sanli (LI10) is encountered two cun proximal to Quchi (LI11). Quchi (LI11) is at the end of the transverse cubital crease when the elbow is flexed. Zhouliao (LI12) is near the lateral margin of the greater tubercle of the humerus. Wuli (LI13) is found by moving inward three cun above the elbow. Binao (LI14) is measured seven cun above the elbow. Jianyu (LI15) is taken at the shoulder tip with the arm raised. Jugu (LI16) is located superior to the shoulder tip. Tianding (LI17) is truly four cun lateral to the throat. Futu (LI18) is five cun lateral to Tiantu (CV22). Heliao (LI19) is five fen lateral to Shuigou (GV26). Yingxiang (LI20) is one cun superior to Heliao (LI19). The acupoints of the Large Intestine Meridian are clearly defined. (Forty acupoints in total, bilateral.)

The Foot-Yangming Stomach Meridian originates at the side of the nose, crossing at the root of the nose (Neiting/Sangen area), where it meets the Bladder Meridian laterally. It descends along the lateral aspect of the nose, enters the teeth, emerges to encircle the lips below, crosses at Chengjiang (CV24), then follows the posterior mandible downward, exits at Daying (ST5), follows Jiache (ST6), ascends anterior to the ear, passes through Guanchong/Shangguan (GB4), follows the hairline, and reaches the forehead. Its branch descends from the front of Daying (ST5) to Renying (ST9), follows the throat, enters the Supraclavicular Fossa (Quepen), passes through the diaphragm, belongs to the Stomach, and connects with the Spleen. Its main trunk descends from the Supraclavicular Fossa, follows the medial aspect of the breast, descends alongside the umbilicus, and enters the Qi Street (Qichong). Another branch originates from the stomach opening, descends along the abdominal interior, reaches the Qi Street to merge with the main trunk, then descends through Biguan (ST31), reaches Futu (ST32), descends into the patella, follows the lateral aspect of the tibia, descends to the dorsum of the foot, and enters the space between the second and third toes. Another branch separates three cun below the knee, descends to enter the lateral space of the second toe. Another branch separates from the dorsum of the foot, enters the space between the great toe, and emerges at its tip. When the meridian qi undergoes pathological changes, symptoms include shivering chills, frequent groaning, yawning, and darkening of the face. Upon onset, the patient dislikes people and fire, startles at the sound of wood, feels palpitations, and desires to stay alone behind closed doors and windows. In severe cases, they may climb high to sing, strip naked, and run. Abdominal rumbling and distension occur, known as Ben Tun Jue (Rebellious Qi Jue). This meridian primarily governs diseases generated by blood, such as mania, malaria, warm pathogenic disorders, sweating, rhinorrhea or epistaxis, ulcers on the lips, neck swelling, sore throat, edema of the large abdomen, pain and swelling of the knee and patella, pain along the chest, breast, Qi Street, thigh, Futu, lateral leg, and dorsum of the foot, and inability to use the second toe. Excess qi causes heat in the anterior body; excess in the Stomach leads to rapid digestion and hunger, and yellow urine. Deficient qi causes coldness and trembling in the anterior body; cold in the Stomach leads to distension. For these conditions: excess is treated with draining, deficiency with tonifying, heat with rapid needling, cold with retention of needles, sinking yang with moxibustion, and neither excess nor deficiency with selection from the meridian itself. In excess, the Renying pulse is three times larger than the Cunkou pulse; in deficiency, the Renying pulse is smaller than the Cunkou pulse. ("E" refers to the root of the nose; "Bi" refers to the thigh; "Bin" refers to the patella; "Fu" refers to the dorsum of the foot; "Ben" refers to running/rushing; "Dan" refers to abdominal distension; "Zhen" refers to sores/rashes.)

The sides of the nose are called "E". Below the cheeks is the "Han". The center of the chin is the "Yi". Above the cheeks is the hairline. Before the hairline is the forehead. The inner thigh is the "Bi". The muscular prominence anterior to the thigh above the knee is Futu. Posterior to Futu is Biguan. The area between the knee tendons is Bin. The tibia is "Xing". The dorsum of the foot is Fu. The Foot-Yangming Stomach Meridian receives connection from the Hand-Yangming Large Intestine Meridian, starting at Yingxiang (LI20) beside the nose, ascending and crossing at the root of the nose, passing Jingming (BL1), descending along the lateral nose, passing Chengqi (ST1), Sibai (ST2), and Juliao (ST3), entering the teeth, emerging to flank the mouth, passing Dicang (ST4) at the corners, encircling the lips, crossing at Chengjiang (CV24), following the posterior mandible, exiting Daying (ST5), following Jiache (ST6), ascending anterior to the ear, passing Xiaguan (ST7), Guanchong (GB4), following the hairline, passing Xuanli (GB5) and Hanyan (GB6), through Touwei (ST8), meeting at Shenting (GV24) on the forehead. Its branch descends from Daying (ST5) to Renying (ST9), follows the throat, passes Shuitu (ST10) and Qishe (ST11), enters the Supraclavicular Fossa, lateral to Yufu (KI27) of the Foot-Shaoyin Kidney Meridian, passes through the diaphragm at Zhongwan (CV12) and Xiaowan (CV10), belongs to the Stomach, and connects with the Spleen. The straight path descends from the Supraclavicular Fossa, follows the medial breast, passing Qihu (ST15), Kufang (ST16), Wuyi (ST17), Yingchuang (ST18), Ruzhong (ST18), Rugen (ST18), Burong (ST21), Chengman (ST22), Liangmen (ST23), Guanmen (ST24), Taiyi (ST25), Roubamen (ST26), flanking the umbilicus, passing Tianshu (ST25), Wailing (ST27), Daju (ST28), Shuidao (ST29), and Guilai (ST29), entering the Qi Street. Another branch originates from the Stomach, starts at the lower opening, follows the abdominal interior, lateral to Huangshu (KI12) of the Foot-Shaoyin Kidney Meridian, within the interior of this meridian, descends to the Qi Street to merge with the previous branch. After merging at the Qi Street, it descends through Biguan (ST31), reaches Futu (ST32), passes Yinshi (ST33) and Liangqiu (ST34), enters the patella, passes Dubi (ST35), descends along the foot dorsum to Chongyang (ST42), Xangu (ST43), enters the medial space of the second toe to Neiting (ST44), ending at Lidui (ST45). The collateral branch separates three cun below the knee, lateral to Zusanli (ST36), descends passing Shanglian (ST37), Tiaokou (ST38), Xialian (ST39), Fenglong (ST40), Jiexi (ST41), Chongyang (ST42), Xangu (ST43), to merge at Neiting (ST44) and Lidui (ST45). Another branch separates from Chongyang (ST42) on the dorsum, enters the great toe space, exits lateral to Xingjian (LR2) of the Foot-Jueyin Liver Meridian, follows the great toe to its tip, connecting with the Foot-Taiyin Spleen Meridian. Pathological changes in Yangming qi cause shivering chills because Yangming corresponds to Wu (noon), where extreme Yang is met by Yin, causing chills. Groaning indicates stagnant Yang seeking release. Yawning indicates Yang seeking to rise. Darkening of the face indicates Yin affecting the upper body. These are signs of Yangming qi pathology. When disease qi reaches the meridian, Yangming meridian disease causes aversion to people and fire, and startling at wood sounds. Since the Stomach channel connects to the Heart, palpitations occur. Yin-Yang struggle causes desire for isolation. Extreme Yang leads to solid limbs, climbing high, singing, stripping, and running due to internal heat. The Yangming meridian passes through the diaphragm, belongs to the Stomach, and connects with the Spleen, causing abdominal rumbling and distension. This is rebellious Qi in the meridian causing these symptoms, hence termed Ben Tun Jue. The Yangming meridian descends along the lateral tibia. Diseases may affect qi without reaching the meridian, show meridian symptoms while rooted in qi, involve mixed meridian and qi pathology, or transition from qi to meridian; thus, they can be analyzed separately or together. The Classic states: Food enters the Stomach, meridians open, and blood qi flows. The Ping Mai Pian states: Water enters the meridians, and blood forms. The Stomach is the Sea of Grain and Water, generating Ying Blood; thus, it governs blood-related diseases like mania, warm malaria, and sweating (due to Stomach heat evaporating fluids). Rhinorrhea/epistaxis is due to meridian heat. Lip ulcers, neck swelling, sore throat, abdominal edema, knee pain, and pain in the chest, thigh, and dorsum are direct meridian diseases. Excess external qi causes anterior heat; excess internal qi causes hunger and yellow urine. Deficient qi causes anterior cold and Stomach cold distension. The Classic says: Three Yang are the channels, Two Yang are the maintenance, One Yang is the pivot. Yangming maintains the anterior body, Taiyang conducts the posterior body, Shaoyang is the pivot of movement. For these Is Dong and Suo Sheng diseases: excess drains, deficiency tonifies, heat uses rapid needling, cold retains needles, sinking uses moxibustion, neutral selects from the meridian. Qi originates in Yangming but is governed by Hand-Taiyin Lung. Thus, discussions on excess/deficiency of Qi focus on Hand-Taiyin and Hand/Foot-Yangming, while other meridians discuss only Is Dong and Suo Sheng. Shang Yugong stated: Hand-Taiyin Is Dong causes lung distension; Foot-Yangming Is Dong causes aversion to people/fire and abdominal rumbling/distension, indicating disease qi affecting meridians and organs. Diseases of Lung, Stomach, and Large Intestine manifest as Qi excess/deficiency, meaning organ/meridian disease affects Yin-Yang Qi. The Three Yin and Three Yang Qi originate from the Five Elements of the Zang-Fu and externally correspond to the Six Channels.