人参 白术（各五两） 浓朴（炙） 细辛（各四两） 生姜（八两，末） 橘皮（三
两） 桂心（二两）
上为细末，炼蜜丸如梧桐子大。饮下十丸，渐加至二十丸，与半夏丸间服亦可。忌桃
、李、雀肉、生葱、生菜。吴升同。
论曰∶呕吐而利者，名霍乱也。原疾之由，皆由肠胃虚冷，饮食过度，触冒风冷，使阴
阳不和，清浊相干，致令挥霍变乱也。或先心痛而吐者；或先腹痛而利者；或吐利俱作者；
或头痛、身体壮热而脉浮洪者；或阳气暴绝而手足逆冷，而脉息微绝者。治之当分阴阳，察
其虚实，辨其冷热，观其脉息。热者凉之，冷者温之，以平为期。《百问》云∶凡霍乱吐利
，热多而渴者，五苓散。寒多不饮水者，理中丸。吐利已，汗出而厥，四肢拘急不解，脉微
欲绝者，通脉四逆加猪胆汁汤。夏月中暑霍乱，大烦渴，四肢逆冷，冷汗出，脚转筋者，香
薷散浓煎，沉冷服即效。凡霍乱之脉得浮洪者易治。微迟者，并气短者难治。
主霍乱，临时方。亦可治男子。（《千金翼》）
人参 白术 干姜 甘草（各一两）
上为细末，炼蜜为丸。每两作五丸，取汤和一丸服之，日十服。吐多、利少者，取枳实
三枚，炙，去穣，四破。水三升，煮取一升，和一丸服之。吐少、利多者，加干姜一累。吐
利干呕者，取半夏半两，泡洗去滑，水二升，煮取一升，和一丸服。若体疼痛不可堪者，水
三升，煮枣三枚，取一升，和一丸服。若吐利大极转筋者，以韭汁洗腹肾，从胸至足踝，勿
逆即止。若体冷微汗，腹中寒，取附子一枚，炮去皮，四破，以水二升，煎取一升，和一丸
服。吐利悉止，脉不出，体尤冷者，可服诸汤补之。
【方剂组成】
人参、白术（各五两）、浓朴（经炙烤处理）、细辛（各四两）、生姜（八两，制成粉末）、橘皮（三两）、桂心（二两）。
【制法与用法】
将上述药材研磨成细末，用炼过的蜂蜜制成如梧桐子大小的丸药。每次服用十丸，逐渐增加至二十丸，也可以与半夏丸交替服用。忌食桃、李、雀肉、生葱、生菜。吴升的观点与此相同。
【病机论述】
论述说：呕吐且伴有腹泻的病症，称为霍乱。这种疾病的起因，都是由于肠胃虚寒，饮食过量，或受风寒侵袭，导致阴阳失调，清气与浊气相互干扰，从而引起突然的挥霍变乱。有的先出现心痛而后呕吐；有的先出现腹痛而后腹泻；有的呕吐和腹泻同时发生；有的头痛、身体高热且脉象浮洪；有的阳气突然衰竭，手足逆冷，脉搏微弱几乎摸不到。治疗时应当区分阴阳，观察虚实，辨别冷热，诊察脉象。热证用凉药治疗，寒证用温药治疗，以恢复平衡为准则。《百问》中说：凡是霍乱吐利，热多且口渴的，用五苓散。寒多且不饮水的，用理中丸。吐利停止后，出汗且四肢厥冷，肢体拘急不缓解，脉搏微弱欲绝的，用通脉四逆加猪胆汁汤。夏季中暑引起的霍乱，大烦渴，四肢逆冷，出冷汗，小腿转筋的，用香薷散浓煎，放凉后服用即见效。凡是霍乱的脉象见浮洪的容易治疗。脉象微迟的，并伴有气短的，难以治疗。
【加减理中丸方】
主治霍乱，为临时应急之方。也可用于治疗男子。（出自《千金翼方》）
人参、白术、干姜、甘草（各一两）。
【制法与用法】
将上述药材研磨成细末，用炼蜜制成丸药。每两药粉做成五丸。取汤水送服一丸，每日服用十次。
若呕吐多、腹泻少的，取枳实三枚，炙烤，去掉瓤，切成四块。用水三升，煮取一升药液，送服一丸。
若呕吐少、腹泻多的，增加干姜一两。
若呕吐、腹泻伴干呕的，取半夏半两，浸泡清洗去滑腻，用水二升，煮取一升药液，送服一丸。
若身体疼痛难以忍受的，用水三升，煮大枣三枚，取一升药液，送服一丸。
若吐泻极度严重导致转筋的，用韭菜汁清洗腹部和肾脏区域，从胸部至足踝，顺着经络方向按摩不要逆向，即可停止。
若身体寒冷微汗，腹中寒的，取附子一枚，炮制去皮，切成四块，用水二升，煎取一升药液，送服一丸。
若吐泻完全停止，但脉搏不出，身体特别冷的，可以服用各种汤药进行补益。
[Composition]
Renshen (Ginseng Radix), Baizhu (Atractylodis Macrocephalae Rhizoma) (each 5 liang), Houpo (Magnoliae Officinalis Cortex, processed by stir-frying), Xixin (Asari Radix et Rhizoma) (each 4 liang), Shengjiang (Zingiberis Recens Rhizoma) (8 liang, powdered), Chenpi (Citri Reticulatae Pericarpium) (3 liang), Guixin (Cinnamomi Ramulus) (2 liang).
[Preparation and Administration]
Grind the above herbs into a fine powder. Mix with refined honey to form pills the size of paulownia seeds. Administer orally with water, starting with 10 pills and gradually increasing to 20 pills. It may also be taken alternately with Banxia Wan (Pinellia Pill). Avoid consuming peaches, plums, sparrow meat, raw green onions, and raw vegetables. Wu Sheng holds the same view.
[Pathogenesis Discussion]
It is stated: Vomiting accompanied by diarrhea is termed Huoluan (Cholera-like disease). The origin of this disease lies in deficiency-cold of the intestines and stomach, excessive food intake, or exposure to wind-cold, causing disharmony between Yin and Yang and interference between clear and turbid qi, resulting in sudden turmoil. Some present with heart pain followed by vomiting; some with abdominal pain followed by diarrhea; some with simultaneous vomiting and diarrhea; some with headache, high fever, and floating-hong pulse; some with sudden collapse of Yang qi, cold extremities, and faint or imperceptible pulse. Treatment should distinguish between Yin and Yang, examine deficiency and excess, differentiate heat and cold, and observe the pulse. Heat patterns are treated with cooling agents; cold patterns are treated with warming agents, aiming for balance. "Baiwen" states: For Huoluan with vomiting and diarrhea, if heat predominates with thirst, use Wuling San (Five-Ingredient Powder with Poria); if cold predominates without desire for water, use Lizhong Wan (Regulate the Middle Pill). After vomiting and diarrhea cease, if sweating and cold limbs persist, limb rigidity does not resolve, and the pulse is faint and nearly absent, use Tongmai Sini Jia Zhuhidan Tang (Decoction to Restore the Pulse with Porcine Bile). For summerheat-induced Huoluan presenting with severe irritability and thirst, cold extremities, cold sweat, and calf cramps, use Xiangru San (Elsholtzia Powder) decocted strongly and taken cold for immediate effect. Generally, Huoluan with floating-hong pulses is easy to treat. Those with faint-slow pulses, especially with shortness of breath, are difficult to treat.
[Jiajian Lizhong Wan Formula]
Mainly for Huoluan, as a temporary emergency formula. It can also treat men. (From "Qianjin Yifang")
Renshen (Ginseng Radix), Baizhu (Atractylodis Macrocephalae Rhizoma), Ganjiang (Zingiberis Rhizoma), Gancao (Glycyrrhizae Radix et Rhizoma) (each 1 liang).
[Preparation and Administration]
Grind the above herbs into a fine powder. Form pills using refined honey. Each liang of powder makes five pills. Take one pill with warm water, ten times daily.
If vomiting is profuse and diarrhea is scant, take three Zhi Shi (Immature Bitter Orange Fructus), stir-fry until hot, remove the pith, cut into four pieces. Decoct in 3 sheng of water until reduced to 1 sheng, and administer with one pill.
If vomiting is scant and diarrhea is profuse, add 1 liang of Ganjiang (Zingiberis Rhizoma).
If vomiting and diarrhea occur with dry heaving, take 0.5 liang of Banxia (Pinelliae Tuber), soak and wash to remove slipperiness, decoct in 2 sheng of water until reduced to 1 sheng, and administer with one pill.
If body pain is unbearable, decoct three Jujubae Fructus (Jujube Fruit) in 3 sheng of water until reduced to 1 sheng, and administer with one pill.
If severe vomiting and diarrhea lead to muscle cramps, wash the abdomen and kidney area with Jiuzhi (Allii Fistulosi Juice) from the chest down to the ankle, massaging along the meridian direction without reversing, which will stop the symptoms.
If the body is cold with slight sweating and abdominal coldness, take one Fuzi (Aconiti Lateralis Radix Praeparata), process by roasting and removing the skin, cut into four pieces, decoct in 2 sheng of water until reduced to 1 sheng, and administer with one pill.
If vomiting and diarrhea have completely ceased but the pulse is absent and the body is extremely cold, various tonic decoctions may be administered.