夫间日疟者。此由邪气与卫气。俱行于六腑。而有时相失不相得。故邪气内搏于五脏。
则道远气深。故其气行迟。不能与卫气皆出。是以间三两日而作也。
治间日疟。身体壮热。时发增寒。大便秘涩。鳖甲散方。
鳖甲（一两涂醋炙令黄去裙 ） 赤芍药（一两） 当归（一两锉微炒） 大青（一两）
知母
（一两）
炒） 天
灵盖（
上件药。捣粗罗为散。每服五钱。用水一大盏。煎至五分。去滓。调天灵盖末
前服之。
治间日疟。或隔日。或三五日。发动无时。知母散方。
知母（一分） 恒山（半分） 鳖甲（一分涂醋炙令黄去裙 ） 桃仁〔二（一）分汤
浸去皮尖
双仁麸炒微黄〕 附子（一分炮裂去皮脐） 糯米（五十粒） 乌梅肉（一枚） 野狼牙（半
分）
上件药。都细锉。用酒一大盏半。浸一宿。五更初煎取八分。去滓。分为二服。空心热
服。将欲发时再服。
治间日疟。发作无时。寒热不止方。
恒山（一两） 鳖甲（一两涂醋炙令黄去裙 ） 川升麻（一两） 栀子仁（半两）
上件药。捣细罗为散。空腹。以温水调二钱。服以微吐为度。未吐再服。
治间日疟。寒热不止。乌梅丸方。
乌梅肉（一两微炒） 桃仁〔二（三）十枚汤浸去皮尖双仁麸炒微黄〕 地骨皮（一两）
豉
心
（一两炒干）
升麻
（一两） 人参（
上件药。捣罗为末。炼蜜和捣三二百杵。丸如梧桐子大。空腹。以暖浆水下二十丸。晚
再服之。
治间日疟。或夜发者方。
恒山（二两） 秫米（一百粒） 竹叶（一两） 石膏（二两）
上件药。都细锉。以水二大盏浸药。露经一宿。明旦煎取一盏二分。去滓。分为二服。
空心一服。未发前一服。当日勿洗手面及漱口。勿食。并用药汁涂五心。及胸前头面。药滓
置于头边。极妙。
又方。
川大黄（半两锉碎微炒） 甘草（一分炙微赤） 恒山（三分） 桂心（一分）
上件药。都细锉。以水二大盏。煮取一盏。去滓。分为二服。空心热服。临发前再服。
治间日疟。或每日发者。雄黄丸方。
雄黄（一两细研） 腊月野狐肝（一两） 阿魏（一分） 朱砂（半两细研） 猢狲头
骨（一两）
天灵盖（半两） 麝香（一分细研）
上件药。生捣罗为末。入研药末令匀。于五月五日午时。炼蜜和丸。如豇豆大。每发时
前。男左女右。以绯帛系一丸于中指上。时时嗅之。后更以醋汤下一丸。
又方。
小麦（一合） 砒黄（一两细研）
上件药。于腊月。以醋浸四十九日。取出焙干。每有患者。取小麦七粒。发前。以冷醋
汤下之。
Intermittent malaria (Jianri Nue) is caused by pathogenic factors (Xieqi) and defensive qi (Weiqi) traveling together through the six fu organs, but occasionally losing synchronization. Consequently, the pathogenic factors press inward upon the five zang organs. Since the disease site is distant and the qi is deep-seated, the qi movement is sluggish and cannot exit simultaneously with the defensive qi. This is why the symptoms manifest every two or three days.
For treating intermittent malaria characterized by high fever, alternating chills and fever, and constipation, use Biejia San (Turtle Shell Powder).
Ingredients: Bie Jia (Testudinis Carapax et Plastrum, 1 liang, prepared with vinegar until yellow, remove skirt edges); Chi Shao Yao (Paeoniae Radix Rubra, 1 liang); Dang Gui (Angelicae Sinensis Radix, 1 liang, sliced and lightly stir-fried); Da Qing (Isatidis Folium, 1 liang); Zhi Mu (Anemarrhenae Rhizoma, 1 liang); Tian Ling Gai (Cranii Humanis Os, 0.5 liang).
Process the above ingredients into a coarse powder. Take 5 qian per dose, decoct with one large cup of water until reduced to 0.5 cup, strain, and mix in the Tian Ling Gai powder. Administer before meals.
For treating intermittent malaria where attacks occur every other day or every three to five days at irregular intervals, use Zhi Mu San (Anemarrhena Powder).
Ingredients: Zhi Mu (Anemarrhenae Rhizoma, 1 fen); Heng Shan (Dichroae Radix, 0.5 fen); Bie Jia (Testudinis Carapax et Plastrum, 1 fen, prepared with vinegar until yellow, remove skirt edges); Tao Ren (Persicae Semen, 1 fen, soaked in water, skin and pointed ends removed, use double-kernel seeds stir-fried with bran until slightly yellow); Fu Zi (Aconiti Lateralis Radix Praeparata, 1 fen, processed until cracked, skin and navel removed); Nuomi (Oryza Sativa Var. Glutinosa, 50 grains); Wu Mei Rou (Mume Fructus Carnosus, 1 piece); Ye Lang Ya (Sarcandrae Herba, 0.5 fen).
Finely chop all ingredients. Soak in 1.5 large cups of wine overnight. At dawn (Wugeng), decoct to obtain 0.8 cup, strain, and divide into two doses. Take warm on an empty stomach, and administer again just before the attack begins.
For treating intermittent malaria with irregular onset and persistent chills and fever, use the following prescription.
Ingredients: Heng Shan (Dichroae Radix, 1 liang); Bie Jia (Testudinis Carapax et Plastrum, 1 liang, prepared with vinegar until yellow, remove skirt edges); Chuan Sheng Ma (Bupleuri Radix, 1 liang); Zhi Zi Ren (Gardeniae Fructus, 0.5 liang).
Grind into a fine powder. On an empty stomach, take 2 qian mixed with warm water. The goal is mild vomiting; if vomiting does not occur, take another dose.
For treating intermittent malaria with persistent chills and fever, use Wumei Wan (Dark Plum Pill).
Ingredients: Wu Mei Rou (Mume Fructus Carnosus, 1 liang, lightly stir-fried); Tao Ren (Persicae Semen, 30 kernels, soaked in water, skin and pointed ends removed, use double-kernel seeds stir-fried with bran until slightly yellow); Di Gu Pi (Lycii Cortex, 1 liang); Chi (Zizyphi Fructus, specifically the heart/core, 1 liang, dried by stir-frying); Sheng Ma (Bupleuri Radix, 1 liang); Ren Shen (Ginseng Radix et Rhizoma, 1 liang).
Grind into powder. Mix with refined honey and pound for 200-300 strokes to form pills the size of paulownia seeds. Take 20 pills on an empty stomach with warm grain water, and repeat in the evening.
For treating intermittent malaria that occurs at night, use the following formula.
Ingredients: Heng Shan (Dichroae Radix, 2 liang); Shumi (Milii Glucini Semen, 100 grains); Zhu Ye (Bambusae Folium, 1 liang); Shi Gao (Gypsum Fibrosum, 2 liang).
Finely chop all ingredients. Soak in 2 large cups of water and leave exposed to the air overnight. Decoct the next morning to obtain 1.2 cups, strain, and divide into two doses. Take one dose on an empty stomach and the other dose before the anticipated attack. On the day of treatment, do not wash hands/face or rinse the mouth, and do not eat. Apply the medicinal juice to the "five centers" (palms, soles, and chest) as well as the chest, head, and face. Place the medicinal dregs near the pillow for optimal effect.
Another formula.
Ingredients: Chuan Da Huang (Rhei Radix et Rhizoma, 0.5 liang, chopped and lightly stir-fried); Gan Cao (Glycyrrhizae Radix et Rhizoma, 1 fen, stir-fried until slightly red); Heng Shan (Dichroae Radix, 3 fen); Gui Xin (Cinnamomi Ramulus Cortex, 1 fen).
Finely chop all ingredients. Decoct in 2 large cups of water until reduced to 1 cup, strain, and divide into two doses. Take warm on an empty stomach, and administer again just before the attack.
For treating intermittent malaria that may occur daily, use Xionghuang Wan (Realgar Pill).
Ingredients: Xiong Huang (Realgar, 1 liang, finely ground); Yehuogan (Vulpis Liver, collected in the twelfth lunar month, 1 liang); Awei (Ferulae Resina, 1 fen); Zhusha (Cinnabar, 0.5 liang, finely ground); Hunsun Tougu (Simiae Cranii Os, 1 liang); Tian Ling Gai (Cranii Humanis Os, 0.5 liang); She Xiang (Moschus, 1 fen, finely ground).
Grind raw ingredients into powder, mix thoroughly with the ground minerals. On the noon hour of the fifth day of the fifth lunar month, mix with refined honey to form pills the size of cowpeas. Before each attack, males tie one pill to the left middle finger and females to the right middle finger using red silk. Sniff the pill intermittently. Subsequently, swallow one pill with vinegar-infused water.
Another formula.
Ingredients: Xiaomai (Tritici Fructus, 1 he); Pi Huang (Arsenicum, 1 liang, finely ground).
In the twelfth lunar month, soak these ingredients in vinegar for 49 days. Remove and dry by baking. When a patient presents, take 7 grains of wheat and administer with cold vinegar-infused water just before the attack.