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The *Suwen* (Basic Questions) states: How is Bi syndrome generated? Qibo replied: When Wind, Cold, and Dampness (Feng, Han, Shi) three pathogens mix and invade together, they combine to form Bi syndrome. Among them, the one where Wind pathogen predominates is called Xing Bi (Moving Bi); the one where Cold pathogen predominates is called Tong Bi (Painful Bi); the one where Dampness pathogen predominates is called Zhuo Bi (Fixed/Heavy Bi). There are five names for Bi syndrome, all arising from these three pathogens invading the Zang organs. Contracted in Spring, it is Jin Bi (Sinew Bi), affecting the Liver, leading to sinew spasms, fright during sleep, increased appetite but frequent urination; contracted in Summer, it is Xue Bi (Blood Bi), affecting the Heart, leading to unsmooth blood vessels, palpitations like drumbeats in the epigastrium, sudden upward rushing of Qi causing panting, dry throat, and a tendency to belch; contracted in Mid-Summer, it is Ji Bi (Muscle Bi), affecting the Spleen, leading to lethargy of the four limbs, coughing, and vomiting of saliva; contracted in Autumn, it is Pi Bi (Skin Bi), affecting the Lung, leading to loss of sensation in the skin, chest fullness with vexation, and occasional retching with pain; contracted in Winter, it is Gu Bi (Bone Bi), affecting the Kidney, leading to heavy bones difficult to lift, frequent abdominal distension, and in severe cases, sitting on the buttocks instead of standing on heels, and bending the spine so the head leans forward. Generally, when Wind predominates, pain wanders up and down without staying in one place, interacting with deficient evil and Qi-Blood, gathering at joints, causing sinews to relax and fail to contract, named Feng Bi (Wind Bi); when Cold predominates, there are spasmodic pains in the four limbs and swollen joints, named Tong Bi (Painful Bi); when Dampness lingers and does not move, with excessive sweating, weakness of the four limbs, numbness of the skin, and mental confusion, named Zhuo Bi (Fixed Bi); when Wind, Cold, and Dampness combine to form Bi, the skin becomes thick and hard, or muscles ache, indicating evil invading the whole body. If evil combats in the blood vessels and persists for years, it forms wheals and wind sores, itching causes no pain, hair falls out, named Ben Bi (Root Bi); among these, there are differences such as Bao Bi (Bladder/Uterus Bi), Chang Bi (Intestine Bi), Xue Bi (Blood Bi), and Re Bi (Heat Bi). Bao Bi refers to internal pain and fullness upon pressing the Small Intestine and Bladder, failure of water pathways to transform, and clear mucus flowing from above; Chang Bi refers to the three pathogens taking advantage of deficiency to invade the Large Intestine, characterized by frequent drinking, mid-meal panting, occasional undigested diarrhea, and urinary obstruction; Xue Bi refers to evil entering the Yin-Blood level, presenting as if the body is constantly blown by a slight breeze, weak bones and emaciation, sweating, and restless tossing during sleep; Re Bi (Heat Bi) occurs when heat shifts from the Zang-Fu organs and encounters the mixture of Wind, Cold, and Dampness, lodging in the meridians and stagnating, where Yang encounters Yin, resulting in a stifling sensation of Bi. Muscles become extremely hot, the body feels like mice running under the skin, lips and tongue ulcerate, and skin color changes. The classics state: In Bi disease, there may be pain or no pain, numbness or coldness or heat, dryness or dampness. Pain is mostly due to Cold. No pain and numbness indicate long-standing disease with deep-seated evil, sluggish Ying-Wei circulation, blocked meridians, and lack of nourishment to the skin, hence no pain and numbness. If Yin Qi is abundant and Yang Qi is scarce, combining with the disease, it manifests as Cold; if Yin Qi is scarce and Yang Qi is abundant, disease Qi overcomes Yang encountering Yin, manifesting as Heat. Excessive sweating and wetness indicate extreme Dampness. Bi without pain: in Bone, heaviness; in Vessels, blood coagulation; in Sinews, flexion without extension; in Flesh, numbness; in Skin, cold. These five do not hurt. Additionally, Zhi Yin (Branching Fluid Retention) can also cause Bi. Zhi Yin is caused by fluid transforming into Phlegm. The treatment method should distinguish which meridian and part the three pathogens have stayed in, whether in the Exterior or Interior, and the excess or deficiency bias. Investigate the cause, examine the symptoms carefully. If caused by the three pathogens, treat according to the affected meridian; if not caused by the three pathogens but arising from other Bi diseases, treat according to those other diseases. Furthermore, Shui Bi (Water Bi) and Bai Hu Li Jie Feng (White Tiger Migratory Joint Wind) syndromes cannot be treated uniformly. It depends on the physician's sincere investigation and treatment for the condition to improve.