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Variola (smallpox) is caused by blood stasis. Treatment should primarily focus on invigorating blood circulation. Therefore, Radix Arnebiae (Zicao) and Flos Carthami (Honghua) are indispensable. However, they are contraindicated if the rash is intensely red accompanied by loose stools. Fructus Crataegi (Shanzha) disperses blood and resolves accumulation; it is contraindicated in cases of Spleen deficiency with anorexia. Radix Glycyrrhizae (Gancao) detoxifies and harmonizes the Middle Jiao; it is contraindicated in cases of abdominal fullness. Pericarpium Citri Reticulatae (Chenpi) strengthens the Spleen and promotes Qi movement; it is contraindicated in cases of spontaneous sweating. Fructus Arecae Catechu (Dafupi) promotes urination and reduces distension; it is contraindicated when diaphoretic methods are required. Semen Armeniacae Amarum (Niubangzi) dispels wind and improves complexion, unblocking orifices and reaching the skin; it is contraindicated in cases of diarrhea. Caulis Tetrapanacis (Mutong) unblocks and drains the Bladder; it is contraindicated in cases of polyuria. Fructus Chebulae (Hezi) and Fructus Mume (Wumei) stop diarrhea, relieve thirst, and astringe sweat; they are contraindicated in cases of constipation. Radix Ginseng (Renshen) and Rhizoma Atractylodis Macrocephalae (Baizhu) support primordial Qi and benefit the Stomach; they are contraindicated in cases of dry blood with severe toxin accumulation. Rhizoma Cimicifugae (Shengma) and Radix Puerariae Lobatae (Gegen) raise and lift Yang; they are contraindicated when the eruption is dense with profuse sweating, or when toxins are severe and interior excess exists. Radix Notopterygii (Qianghuo) and Rhizoma Angelicae Dahuricae (Baizhi) defeat toxins and promote pus discharge; they are contraindicated in cases of Qi deficiency. Radix Angelicae Sinensis (Danggui) and Rhizoma Chuanxiong (Chuanxiong) invigorate blood and nourish blood; they are contraindicated in cases of blood heat leading to black and rotting lesions. Radix Paeoniae Alba (Shaoyao) and Radix Rehmanniae Preparata (Dihuang) cool blood and assist Yin; they are contraindicated in cases of cold blood preventing eruption. Rubellus (Chensha) calms the spirit, removes heat, and relieves irritability; it is contraindicated in cases of grayish-white non-erupting rashes. Oryza Sativa (Nuomi) warms the Stomach and solidifies the Spleen; it is contraindicated in cases of Qi stagnation. Radix Saposhnikoviae (Fangfeng) dispels wind and clears heat; it is contraindicated in cases of asthma. Radix Aucklandiae (Muxiang) regulates Qi and disperses cold, stopping abdominal pain and draining Liver fire; it is contraindicated in cases of dark spots, dryness, and thirst. Cortex Magnoliae Officinalis (Houpo) warms the Stomach and treats distension; it is contraindicated in cases of irritability and thirst. Radix Asari (Xixin) disperses outward, moves upward, and unblocks the Lungs; it is contraindicated in cases of dryness and heat. Radix Bupleuri (Chaihu) releases the exterior and penetrates heat; it is contraindicated in cases of ascending Qi. Radix Peucedani (Qianhu) eliminates phlegm and treats cough; it is contraindicated in cases of diarrhea. Rhizoma Pinelliae Preparata (Banxia) eliminates phlegm and stops cough; it is contraindicated in cases of dryness and thirst. Herba Ephedrae (Mahuang) and Folium Perillae (Zisu) release the exterior and drive out cold; they are contraindicated in cases of exterior deficiency. Rhizoma Zingiberis Recens (Shengjiang) and Cortex Cinnamomi (Guirou) assist blood and warm the interior; they are contraindicated in cases of reckless bleeding due to blood heat, presenting as dry red or scorched purple eruptions. Radix Aconiti Lateralis Preparata (Fuzi) restores Yang and supplements Yuan Qi, treating deficiency-cold and cold extremities; it is contraindicated in cases of restlessness. Radix Rhei Palmati (Dahuang) purges intense heat; it is contraindicated in cases of Stomach deficiency and poor appetite. Human teeth (Renya) raise eruptions and expel sunken Kidney pathogens; they are contraindicated in cases of blood heat with toxin sinking. Fructus Gardeniae (Shanzhi) descends fire; it is contraindicated in cases of Qi deficiency with loose stools. Cornu Rhinocerotis (Xijiao) cools blood and stops epistaxis; it is contraindicated during the pustule stage. Cortex Moutan (Mudanpi) moves blood and returns it to its vessels; it is contraindicated in cases of excessive sweating before eruption. Fructus Myristicae (Roudoukou) strengthens the Spleen and stops diarrhea; it is contraindicated in cases of constipation. Radix Platycodi (Jiegeng) opens depression and guides downward; it is contraindicated when purgative methods are used. Periostracum Cicadae (Chantui) drives out wind and disperses toxins; it is contraindicated in cases of exterior deficiency with sweat collapse. Fructus Aurantii (Zhike) broadens the chest and directs Qi downward; it is contraindicated in cases of Qi deficiency with sinking. Fructus Coriandri (Huisui) and Resina Frankincense (Ruxiang) can be burned to open orifices; they are contraindicated in cases of blood heat with severe toxins, manifesting as irritability, thirst, epistaxis, and sweating. Decoction of Cortex Phellodendri (Huangbai), Semen Phaseoli Volubilis (Lvdou), and Radix Glycyrrhizae (Sheng Gancao) in equal parts applied as a paste to the eye orbits beforehand, or using carmine around the eyes and ears to prevent variolous invasion of the eyes, is contraindicated after the eruption has appeared. Upon the onset of fever, taking three cun of loofah near the stem, including seeds, calcined to ash, taken with wine and Rubellus, can make the eruption sparse; this is contraindicated once the macules appear. Taking this annually on the Dragon Boat Festival can prevent smallpox over time.