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(Renya, Human Teeth) Enters the Kidney channel to push out pathogenic toxins.
Renya (Human Teeth) (specifically enters the Kidney channel). Flavor: salty; Nature: warm. Its function is specifically for treating *douye* (inverted and depressed smallpox lesions, where lesions fail to erupt and instead become dark and sunken). This is because smallpox sometimes fails to erupt smoothly, instead presenting with black depression, mostly due to toxin qi penetrating deeply into the body.
Therefore, it is necessary
to use this herb to emit the toxin from within. Li Shizhen said: Teeth are the external indicator of the Kidney and the surplus of bone essence. The toxin of smallpox emerges from the Kidney. During the growth phase of the lesions, if externally invaded by wind-cold and turbid air, the couli (skin pores and interstices) become closed, blood flow becomes stagnant, and the toxin cannot exit. Or it may turn black and invert. It is appropriate to use this substance administered with wine and musk, allowing it to penetrate the Kidney channel, emit the toxic qi, restore the circulation of heat, and make the lesions naturally red and vibrant. This belongs to "jieji" (drastic agents that forcefully eliminate pathogens). If the toxin lies latent in the Heart, causing coma and unconsciousness, or if there is Qi deficiency with pale complexion, itching and collapse without pus formation, or symptoms of hot pruritus and purple blisters, only detoxification and tonifying deficiency are appropriate. If mistakenly used, it will cause oppression and hoarseness, leading to an incurable condition. How can one not be cautious!
(Gao Wu's *Douzhen Guanjian* records: Zuo Zhongshu stated that cases turning black and returning to the Kidney should use Renya San. However, if the toxin has already returned to the Kidney, how can Renya still treat it?)
Used to reduce fire toxin.

Although toxin manifestations appear on the exterior, the pathological trend has transmitted inward; therefore, herbs should clear and resolve from within. Thus, detoxification is an indispensable part of formulas for treating toxins.
However, people
only know that Jinyinhua (Honeysuckle Flower), Niubangzi (Arctii Fructus), and Gancao (Licorice Root) are detoxifying substances, and indiscriminately administer them for all types of toxin syndromes. They do not realize that toxins formed due to Heart heat can be resolved by Huanglian (Coptidis Rhizoma) and Lianqiao (Forsythiae Fructus); those formed due to Lung fire can be resolved by Huangqin (Scutellariae Radix); those formed due to Liver fire can be resolved by Danshencao (Gentianae Radix), Qingdai (Indigo Naturalis), and Lanzi (Isatidis Folium); those formed due to Stomach fire or Stomach toxin can be resolved by Shigao (Gypsum Fibrosum), Zhuye (Bambusae Folium), and Dahuang (Rhei Radix et Rhizoma); and those formed due to Kidney fire can be resolved by Huangbai (Phellodendri Cortex) and Zhimu (Anemarrhenae Rhizoma). Furthermore, when toxin resides in the intestines and stomach, manifesting as carbuncles, sores, or breast obstruction, Loulu (Leuzeae Rhizoma) is appropriate to unblock; when manifesting as unceasing xiaoke (wasting-thirst), Luudou (Vigna radiata) boiled in water for drinking is appropriate; when manifesting as intestinal bleeding, Baitouweng (Pulsatillae Radix) is appropriate to resolve; when manifesting as epidemic malignant toxin, Jinzhi (Gold Water) and Renzhonghuang (Human Excrement Cake) are appropriate to purge. As for Yangmei chuang (Kaposi's sarcoma-like lesions or syphilitic ulcers), which mostly belong to Liver-Kidney toxin eruption, Tufuling (Smilax Glabrae Rhizoma) is appropriate to clear; Houbi (sore throat) and yantong (throat pain), mostly belonging to phlegm-fire stasis knotting, Shegan (Belamcandae Rhizoma) is appropriate to open; Heart-Kidney fire blazing, Shan Dougen (Sophorae Tonkinensis Radix) is appropriate to extinguish; Guizhu (ghost infection) and luoli (scrofula), with ulceration and spreading, mostly belonging to meridian and Spleen toxin accumulation, Earthworm (Pheretima) is appropriate to transform; Kouyan xie (deviation of mouth and eye), carbuncles, hemorrhoids, and fistulas, mostly belonging to meridian and gastrointestinal toxin eruption, Snail (Helix Aspersa) is appropriate to treat; Ruyong (mastitis) and luyan (breast cancer), mostly arising from Liver-Stomach heat, Pugongying (Taraxaci Herba) is appropriate to heal; Echuang (malignant sores) failing to heal, mostly belonging to Heart-Lung phlegm knotting, Beimu (Fritillariae Bulbus) is appropriate to remove; Wuming dingzhong (nameless carbuncles), malignant sores, snake bites, luoli, and tubercles, mostly belonging to unresolved toxin condensation, Shancigu (Cremastrae Pseudobulbus) is appropriate to treat; Urgent toxin tendency with incessant coughing and expectoration, mostly belonging to Middle Qi deficiency, Qini (Asari Radix et Rhizoma? Note: Text says 荠苨, likely Adenophorae Radix or similar, here translated as Qini) is appropriate to moderate. Others include: for non-resolving carbuncles, using rice vinegar with herbs; for persistent hot saliva and uncleared accumulations, using Bai Fan (Alum) and Zao Bai Er Fan (likely referring to specific alum preparations or soap-based agents); for carbuncle swelling and persistent chest heat, using Gancao Jie (Licorice Node) is appropriate. All these contain profound intent and must not be neglected. For highly toxic substances like Banmao (Mylabris) and Fengxianzi (Croton Tiglium Seed), symptoms must be carefully assessed and treatment adjusted accordingly; negligence in any aspect is unacceptable.