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On the upper face, the center of the philtrum (Ren Zhong) is called Longquan (Dragon Spring), the sides of the philtrum are called Huxu (Tiger's Whiskers), and the high bone on the face is called Quangu (Zygomatic Bone). These areas are all locations where the Yangming meridians and collaterals circulate. Carbuncles (Ding, 疔) arising in these three places vary in severity; physicians should treat them based on their light or heavy nature, without needing to distinguish between their specific differences.

The milder cases often result from the confluence of Wind-Heat pathogens. Initially, the lesion resembles a mosquito bite, but the base and surrounding area are already hard and swollen, accompanied by aversion to cold and fever. By the next day, the apex breaks open like a peppercorn. Externally, a perimeter paste (Wei Yao) is applied. The apex is treated with Baixue Dan (Snow White Pill), covered with Wanying Gao (Ten Thousand Responses Plaster). Every other day, the plaster is removed; if the apex appears stiff and necrotic, Sheng Gao (Ascension Paste) is applied. After another interval, removing the paste allows the hard necrotic tissue to fall off naturally, followed by the discharge of pus. Internal medication includes Antelope Horn (Lingyang Jiao), Dandelion Root (Dideng Cao), Honeysuckle Flower (Yinhua), Moutan Cortex (Danpi), Anemarrhena Rhizome (Zhimu), Forsythia Fruit (Lianqiao), Coptis Rhizome (Huanglian), and Gardenia Fruit (Shanzhi). If fire heat is excessive and severe, Xijiao Dihuang Tang (Rhinoceros Horn and Rehmannia Decoction) or Huanglian Jiedu Tang (Coptis Detoxification Decoction) should be used immediately. If the toxin does not penetrate, processed silkworms or horn thorns are used to pierce it. Once pus is discharged and swelling subsides, the course is generally seven days, after which the pus is absorbed and the wound closes.

The severe cases may arise from internal injury due to the Seven Emotions (Qi Qing), or from consuming rich, greasy foods, strong wine, and roasted meats, leading to the accumulation of heat toxins in the Five Zang organs, causing pathogenic toxins to cluster and erupt. The Classics state: "Rich and greasy foods cause carbuncles and ulcers." This refers to such cases. Initially, the shape resembles a millet grain or a blister. Palpation reveals a deep root, as if nailed to the bone, with unbearable pain. The base spreads diffusely without penetrating, the face and eyes swell, or there is hard red swelling, aversion to cold, burning fever, nausea, vomiting, and limb stiffness or spasms. After three to four days, trismus (lockjaw) resembling spasm may occur, along with blurred consciousness. This is because fire toxins have penetrated into the Pericardium (Xin Bao), known as "Zouhuang Ding" (Roaming Yellow Carbuncle, referring to septicemia/toxemia from carbuncle), a critical condition with a mortality rate of nine out of ten. Suitable treatments include Zixue Dan (Purple Snow Pill), Zhibao Dan (Precious Treasure Pill), and Xijiao Dihuang Tang. External treatment follows the previous methods. Additionally, an ancient formula, Mingdan (Life-Restoring Pill), can be used by placing one pill into the wound head and covering it with a plaster. If the patient loses consciousness or has tight jaw muscles, Mingdan powder mixed with green onion and wine can be administered forcibly. If red threads (red streaks indicating lymphangitis) appear, they should be promptly pricked with a needle at the end of the red thread to release bad blood and drain the toxin, offering a chance for survival. In cases where residual toxins flow through the collaterals, causing widespread Liu Zhu (flowing abscesses) throughout the body, the treatment is the same as that for Yang-pattern Liu Zhu.