脉 脉诀云∶疟脉自弦。弦迟多寒。弦数多热。弦小紧者宜下。弦迟宜温。弦数宜汗。浮大
而滑宜吐。洪数无力为虚。代散则死。
症 内经曰∶夏伤于暑。秋必痢疟。盖先热后寒。名曰温疟。但热不寒。名曰瘅疟。经年不
瘥。结成 瘕。名为老疟。亦曰疟母。寒热身重。骨节烦疼。胀满自汗。为湿疟。寒热不除
。但惨 振栗。病以时作。为牝疟。因伤食而得为食疟。一岁之中。长幼相似。谓之疫疟。
愚按内经、明言夏伤于暑所致。何世医悉谓脾寒。而用温热之药。盖战栗恶寒者。火极似水。
亢则害。承乃制故也。又按丹溪云∶疟因暑邪舍于荣卫之间。腠理不密。复遇风寒。闭而不
出。舍于肠胃之外。与荣卫煎行。昼行于阳。夜行于阴。并则病作。离则病止。并于阳则热
。并于阴则寒。浅则日作。深则间日。在气则早。在血则晏。渴者燥胜。不渴者湿胜也。机
要云∶在太阳经为寒疟。治多汗之。阳明经为热疟。治多下之。少阳经为寒热疟。治多汗之
。此三阳经受病。谓之暴疟。发在夏至后处暑前。乃伤之浅者。在三阴经。则总谓之温疟。
发在处暑后冬至前。乃伤之重者。此说良是。其三阴经则作于子午卯酉日。少阴疟也。作于
寅申巳亥日。厥阴疟也。辰戌丑未日。太阴疟也。临症宜详辨之。
治 丹溪云∶疟得于暑。当以汗解。或汗不得出。郁而成痰。宜养胃化痰。发汗为主。邪气
得出。自然和也。无汗要有汗。散邪为主。带补。小柴胡,加川芎、苍术、升麻、葛根之
类。有汗要无汗。扶正为主。带散。以参、 、归、术、芍药、黄柏、麦冬、五味、之类。
补而收之。虚者。必用参术一二帖托住。其气不使下陷。后随症用他药。大渴大热。头疼如
破。小柴胡,去半夏,加川芎、石膏、知母主之。暑疟。宜人参白虎汤。有痰者。二陈加
常山吐之。不食者。必从食上得。当以食治。平胃散。加山楂、神曲、草果、青皮主之。
疟母在左胁下。令人自汗作痛。以青蒿、鳖甲为主。佐以三棱、莪术、香附、青皮、桃仁
、治之。凡疟数发之后。便宜小柴胡,加常山、草果、青皮、乌梅、截之。久则中气虚弱。
病愈深而难治矣。
方 柴苓二陈汤治诸疟。热多寒少者宜服。
柴胡 白术 苍术(各一钱五分) 人参 半夏(姜制) 黄芩(各一钱) 藿香 川芎 茯苓 陈皮
青皮(各八分) 甘草(三分) 浓朴(七分)
上作一服。姜三片。枣一枚。水一钟半。煎八分。食远服。
初发阴阳未分。加猪苓、泽泻(各八分)、桂(四分)。
若一日一发。午前者邪在阳分。加黄 (一钱)、添茯苓、半夏(各五分)。
热甚。头痛。加石膏(一钱五分)、葱白汁(二匙)。
口渴。加石膏(一钱五分)、知母(一钱)、麦门冬(一钱)。
间日。或三日。午后。或夜发者。加当归、芍药、地黄、知母(各一钱)、酒红花、酒柏、升
麻(各四分)、此邪在阴分。提起阳分。方可截。
若间一日。连二日。或日夜各发者。气血俱病。加黄 (一钱)、添人参、茯苓(各五分)、以
补气。加当归、芍药、地黄(各一钱五分)、以补血。
阳疟多汗。加黄 (一钱五分)、以敛之。无汗。加葛根(一钱五分)、以发之。
阴疟多汗。加当归、芍药、地黄、黄柏、知母(各二钱)、以敛之。
无汗。倍柴胡、苍术,加升麻(七分)、葛根(一钱五分)、以发之。
胃弱食少。或服截药。伤脾胃。食少者。添人参(五分)、芍药(酒炒)、麦芽(各一钱)、砂仁、
(五分)、扁豆(八分)。
若因食积者。加山楂、神曲、枳实、草果(各一钱)、黄连(四分)、瘴疟。加槟榔、知母、葛
根、白芷(各一钱)、乌梅(三个)。
疟后变痢疾。补虚清热为主。添人参(五分),加砂仁(七分)、扁豆、黄连(各一钱)、木香、
(七分)、当归(一钱二分)、芍药(一钱五分)、槟榔(七分)、乌梅(二个)。
若欲截之。加常山(一钱五分)、槟榔、草果(各一钱)、乌梅(七个)、水二钟煎空心服。
若日久虚疟。或 疟。连岁不已。本方。去浓朴、苍术、川芎、藿香、青皮、减柴胡、
黄芩、一半。加黄 、当归(各一钱五分)、白芍药、知母、青蒿、地骨皮(各一钱)、鳖甲、
(九棱或七棱者炙二钱)。
热多枣少者。或大渴者。加石膏(一钱五分)、知母、葛根(各一钱)、麦冬、山栀(各八分)、
添黄芩(五分)。
寒多热少。或但寒不热。加丁香(七分)、官桂(一钱)、干姜(一钱)、草果(一钱)、甚者。加
附子(一钱)、减柴芩一半。
春疟。加防风、干葛、白芷(各一钱)。
夏疟。加黄连、扁豆(各一钱)、香薷(一钱
秋疟。加知母、归身、贝母、杏仁、麦冬(各一钱)。
冬疟。加杏仁(一钱)、桂枝(八分)、干姜(七分)、寒多。更加丁香(五分)。
若日久寒热不多。或无寒而但微热者。邪气已尽。夏月。用清暑益气汤。余月。用补中益气
汤。加麦冬、黄柏、短母(各八分)、滋补气血。截后调理。亦同此条。
又方 截疟丹截诸疟神效。历试有验。
人参(二两去芦) 雄黄(一两六钱另研) 辰砂(六钱另研)
上三味各为末。称定。于五月五日取五家粽为丸。豆大。大人十丸。小儿五丸。发日。五更
空心无根水煎青蒿汤送下。忌生冷鸡鱼一月。
[Pulse]
The *Mai Jue* (Pulse Mantra) states: The pulse of malaria naturally presents as a string-like (Xian) pulse. A string-like and slow pulse indicates excess cold; a string-like and rapid pulse indicates excess heat; a string-like, small, and tight pulse is suitable for purgation; a string-like and slow pulse is suitable for warming; a string-like and rapid pulse is suitable for diaphoresis; a floating, large, and slippery pulse is suitable for emesis; a洪 (Hong, surging) and rapid pulse that is forceless upon pressure indicates deficiency; a Dai (intermittent) or San (scattered) pulse portends death.
[Symptoms]
The *Neijing* (Inner Canon) states: Summer injury by summerheat leads to dysentery or malaria in autumn. If fever precedes chills, it is called Wen Nue (Warm Malaria); if there is only fever without chills, it is called Dan Nue (Fiery Malaria); if it persists for years and forms a mass, it is called Lao Nue (Old Malaria), also known as Nue Mu (Malaria Mass). If there are alternating chills and fever with heavy body, painful joints, abdominal distension, and spontaneous sweating, it is Shi Nue (Damp Malaria). If chills and fever do not cease, but there is only severe trembling and aversion to cold, with attacks occurring at regular times, it is Pin Nue (Yin Malaria). If caused by food stagnation, it is Shi Nue (Food Stagnation Malaria). If all ages in a year suffer similarly, it is Yi Nue (Epidemic Malaria).
My commentary: The *Neijing* explicitly states it is caused by summerheat injury in summer. Why do later physicians attribute it entirely to Spleen cold and use warming herbs? In fact, trembling and aversion to cold are manifestations of extreme heat resembling water; when hyperactivity reaches its limit, it causes harm, requiring a controlling force to regulate it.
Furthermore, according to Danxi: Malaria occurs when summerheat pathogens lodge between the Ying (Nutritive) and Wei (Defensive) levels. If the Couli (skin pores and interstices) are not dense, and wind-cold is encountered, they close up and cannot exit, lodging outside the stomach and intestines. They simmer and circulate with the Ying and Wei Qi. During the day, they travel in the Yang aspect; at night, in the Yin aspect. When they merge, disease arises; when they separate, disease ceases. Merging in Yang causes heat; merging in Yin causes cold. Shallow involvement leads to daily attacks; deep involvement leads to every-other-day attacks. Involvement in Qi results in early onset; involvement in Blood results in late onset. Thirst indicates dryness prevailing; no thirst indicates dampness prevailing.
The *Jiyao* states: Involvement of the Taiyang Channel manifests as Han Nue (Cold Malaria), treated mostly with diaphoresis; involvement of the Yangming Channel manifests as Re Nue (Heat Malaria), treated mostly with purgation; involvement of the Shaoyang Channel manifests as Han Re Nue (Cold-Heat Malaria), treated mostly with diaphoresis. Disease in these three Yang channels is called Bao Nue (Acute Malaria), occurring from after Summer Solstice to before End of Heat, indicating shallow pathogen invasion. Involvement of the three Yin channels is collectively called Wen Nue, occurring from after End of Heat to before Winter Solstice, indicating heavy pathogen invasion. This theory is sound. Among the three Yin channels: attacks on Zi, Wu, Mao, You days are Shaoyin Malaria; attacks on Yin, Shen, Si, Hai days are Jueyin Malaria; attacks on Chen, Xu, Chou, Wei days are Taiyin Malaria. Clinical differentiation should be detailed.
[Treatment Principles]
Danxi stated: Malaria acquired from summerheat should be resolved via diaphoresis. If sweat cannot be produced, stagnation transforms into phlegm; one should nourish the Stomach and resolve phlegm, prioritizing diaphoresis. Once the pathogen exits, harmony returns. For no sweat, promote sweating to scatter the pathogen, accompanied by tonification, using Xiao Chai Hu Tang (Minor Bupleurum Decoction) plus Chuanxiong, Cangzhu, Shengma, Ge Gen, etc. For excessive sweat, stop sweating by supporting the Righteous Qi, accompanied by scattering the pathogen, using Renshen, [missing character], Danggui, Baizhu, Shaoyao, Huangbai, Maidong, Wuweizi, etc., to tonify and astringe. For deficiency, Renshen and Baizhu must be used for one or two doses to support the Qi and prevent sinking, followed by other herbs based on symptoms. For extreme thirst, high fever, and headache like splitting, use Xiao Chai Hu Tang, remove Banxia, add Chuanxiong, Shigao, Zhimu. For Summerheat Malaria, use Renshen Baihu Tang (Ginseng White Tiger Decoction). For phlegm, use Er Chen Tang (Two-Cured Decoction) plus Changshan to induce vomiting. For anorexia, it stems from food; treat via digestion, using Pingwei San (Peaceful Stomach Powder) plus Shanzha, Shenqu, Caoguo, Qingpi.
For Nue Mu (Malaria Mass) under the left hypochondrium causing spontaneous sweating and pain, use Qinghao and Biejia as main herbs, assisted by Sanleng, Ezhu, Xiangfu, Qingpi, Taoren. After multiple malaria attacks, use Xiao Chai Hu Tang plus Changshan, Caoguo, Qingpi, Wumei to intercept the malaria. Prolonged duration weakens the Middle Qi, making the disease deeper and harder to treat.
[Formulas]
Chai Ling Er Chen Tang treats various malarias, suitable for those with more heat than cold.
Chaihu, Baizhu, Cangzhu (each 1.5 qian), Renshen, Banxia (processed with ginger), Huangqin (each 1 qian), Huoxiang, Chuanxiong, Fuling, Chenpi, Qingpi (each 0.8 qian), Gancao (0.3 qian), Nongpo (0.7 qian).
Take as one dose, add three slices of Shengjiang, one Zao, 1.5 zhong of water, decoct to 0.8 zhong, take far after meals.
At initial onset when Yin and Yang are undifferentiated, add Zhuling, Zexie (each 0.8 qian), Guizhi (0.4 qian).
If once daily, attacking before noon, the pathogen is in the Yang aspect; add Huangqi (1 qian), increase Fuling, Banxia (each 0.5 qian).
For intense heat and headache, add Shigao (1.5 qian), Congbai juice (2 chi).
For thirst, add Shigao (1.5 qian), Zhimu (1 qian), Mendumdong (1 qian).
For every-other-day or third-day attacks, or afternoon/night attacks, add Danggui, Shaoyao, Dihuang, Zhimu (each 1 qian), Jiu Honghua, Jiu Bai, Shengma (each 0.4 qian); this indicates pathogen in the Yin aspect, lift to the Yang aspect to intercept.
If skipping one day, then two consecutive days, or attacking once day and once night, both Qi and Blood are diseased; add Huangqi (1 qian), increase Renshen, Fuling (each 0.5 qian) to tonify Qi; add Danggui, Shaoyao, Dihuang (each 1.5 qian) to tonify Blood.
For Yang Malaria with excessive sweat, add Huangqi (1.5 qian) to astringe. For no sweat, add Gegen (1.5 qian) to induce sweat.
For Yin Malaria with excessive sweat, add Danggui, Shaoyao, Dihuang, Huangbai, Zhimu (each 2 qian) to astringe.
For no sweat, double Chaihu, Cangzhu, add Shengma (0.7 qian), Gegen (1.5 qian) to induce sweat.
For weak Stomach and poor appetite, or damage to Spleen/Stomach by interception drugs, adding Renshen (0.5 qian), Shaoyao (wine-fried), Maiya (each 1 qian), Sharen (0.5 qian), Bidou (0.8 qian).
For food accumulation, add Shanzha, Shenqu, Zhishi, Caoguo (each 1 qian), Huanglian (0.4 qian).
For Zhang Nue (Miasmic Malaria), add Binglang, Zhimu, Gegen, Baizhi (each 1 qian), Wumei (3 pieces).
If malaria transforms into dysentery, prioritize tonifying deficiency and clearing heat; add Renshen (0.5 qian), add Sharen (0.7 qian), Bidou, Huanglian (each 1 qian), Muxiang (0.7 qian), Danggui (1.2 qian), Shaoyao (1.5 qian), Binglang (0.7 qian), Wumei (2 pieces).
To intercept, add Changshan (1.5 qian), Binglang, Caoguo (each 1 qian), Wumei (7 pieces), decoct in 2 zhong of water, take on empty stomach.
For prolonged deficiency malaria, or [missing character] malaria persisting for years, use this formula, remove Nongpo, Cangzhu, Chuanxiong, Huoxiang, Qingpi; halve Chaihu, Huangqin. Add Huangqi, Danggui (each 1.5 qian), Baishaoyao, Zhimu, Qinghao, Digupi (each 1 qian), Biejia (roasted 2 qian, nine-pronged or seven-pronged).
For more heat and less sweat, or extreme thirst, add Shigao (1.5 qian), Zhimu, Gegen (each 1 qian), Maidong, Shanzhi (each 0.8 qian), increase Huangqin (0.5 qian).
For more cold and less heat, or only cold without heat, add Dingxiang (0.7 qian), Guanzi (1 qian), Ganjiang (1 qian), Caoguo (1 qian); for severe cases, add Fuzi (1 qian), halve Chaihu, Huangqin.
For Spring Malaria, add Fangfeng, Gange, Baizhi (each 1 qian).
For Summer Malaria, add Huanglian, Bidou (each 1 qian), Xiangru (1 qian).
For Autumn Malaria, add Zhimu, Guishen, Beimu, Xingren, Maidong (each 1 qian).
For Winter Malaria, add Xingren (1 qian), Guizhi (0.8 qian), Ganjiang (0.7 qian); for more cold, add Dingxiang (0.5 qian).
If long-term mild chills/fever or only slight heat without cold, the pathogen is exhausted. In summer, use Qingshu Yiqi Tang (Clear Summerheat and Boost Qi Decoction). In other months, use Buzhong Yiqi Tang (Tonify the Middle and Augment Qi Decoction), add Maidong, Huangbai, Zhimu (each 0.8 qian) to tonify Qi and Blood. Post-interception regulation follows this principle.
Another Formula: Jie Nue Dan (Malaria-Intercepting Pill) is miraculous for all malarias, proven effective.
Renshen (2 liang, remove rhizome), Xionghuang (1.6 liang, ground separately), Chensha (6 qian, ground separately).
Grind the three ingredients into powder, weigh accurately. On the fifth day of the fifth month, make pills from Zong rice of five families, size of beans. Adults: 10 pills; Children: 5 pills. On the attack day, at dawn, take on empty stomach, delivered with Qinghao decoction made with Wugen water (rainwater/snowwater). Avoid raw/cold foods, chicken, and fish for one month.