(味之浓者阴中之阴味浓则泄酸苦咸气寒是也)
黄连 气寒味苦无毒瓦斯味俱浓可升可降阴中阳也入手少阴经其用有六泻心藏火一也去中焦湿热二也诸疮必用
三也
去风湿四也赤眼暴发五也止中部见血六也张仲景治九种心下痞五等泻心汤皆用之〔海〕入手少阴苦燥故入心火就
燥也然
泻心其实泻脾也为子能令母实实则泻其子治血防风为上使黄连为中使地榆为下使去须铡细用
黄芩 气寒味苦无毒可升可降阴也阴中微阳入手太阳血分〔洁〕气凉味苦甘气浓味薄浮而升阳中阴也
入手少阳阳明
经酒炒则上行〔垣〕黄芩之中枯而飘者泻肺火利气消痰除风热消肌表之热细实而坚者泻大肠火养阴退阳补膀胱寒
水滋其
化源高下之分与枳实枳壳同例〔洁〕黄芩之用有九泻肺热一也上焦皮肤风热风湿二也去诸热三也利胸中气四也消
痰膈五
也除脾经诸湿六也夏月须用七也妇人产后养阴退阳八也安胎九也酒炒上行主上部积血非此不能除下利脓血腹痛后重身
热久不能止者与芍药甘草同用之凡诸疮痛不可忍者宜黄连苦寒之药详上下分身稍及引经药用之〔颂〕张仲景治伤
寒心下
痞满泻心汤凡四方皆用黄芩以其主诸热利小肠故也又太阳病下之利不止喘而汗出者有葛根黄芩黄连汤及主妊娠安胎散
亦多用之〔珍〕洁古老人言黄芩泻肺火治脾湿东垣言片芩治肺火条芩治大肠火丹溪言黄芩治上中二焦火而仲景治
少阳证
小柴胡汤太阳少阳合病下利黄芩汤少阳证下后心下满而不痛泻心汤并用之成无己言黄芩苦而入心泄痞热是黄芩能入手
少阴阳明手足太阴少阳六经矣盖黄芩气寒味苦色黄带绿苦入心寒胜热泻心火治脾之湿热一则金不受刑一则胃火不流入
肺即所以救肺也肺虚不宜者苦寒伤脾胃损其母也少阳之证寒热胸胁痞满默默不欲饮食心烦呕或烦或痞或小便不利虽曰
病在半表半里而胸胁痞满实兼心肺上焦之邪心烦喜呕默默不欲饮食又兼脾胃中焦之证故用黄芩以治手足少阳相火黄芩
亦少阳本经药也成无己注伤寒论但云柴胡黄芩之苦以发传邪之热芍药黄芩之苦以坚敛肠胃之气殊昧其治火之妙杨士瀛
直指方云柴胡退热不及黄芩盖亦不知柴胡之退热乃苦以发之散火之标也黄芩之退热乃寒能胜热折火之本也仲景又云少
阳病腹中痛者去黄芩加芍药心下悸小便不利者去黄芩加茯苓似与别录治少腹绞痛利小肠之文不合成氏言黄芩寒中苦能
坚肾故去之盖亦不然至此当以意逆之辨以脉证可也若因饮寒受寒腹中痛及饮水心下悸小便不利而脉不数者是里无热证
则黄芩不可用也若热厥腹痛肺热而小便不利者黄芩其可不用乎故善观书者先求其理毋徒泥其文去皮并黑腐铡细竹筛齐
用
黄柏 气寒味苦无毒瓦斯味俱浓沉而降阴也苦浓微辛阴中之阳入足少阴经为足太阳引经药〔垣〕治肾水
膀胱不足诸痿
厥脚膝无力于黄 汤中少加用之使两膝中气力涌出痿即去矣蜜炒此一味为细末治口疮如神瘫痪必用之药泻膀胱之热利
下窍泻膀胱经火补本经及肾不足苦寒安蛔疗下焦虚坚肾经曰苦以坚之足少阴剂肾苦燥故肾停湿也栀子黄芩入肺黄连入
心黄柏入肾燥湿所归各从其类也活人书解毒汤上下内外通治之去皮铡碎生用则降实火熟用酒制则治上盐制则治下蜜制
则治中而不伤胃
栀子 气寒味苦无毒〔洁〕气薄味浓轻清上行气浮而味降阳中阴也〔垣〕沉也阴也入手太阴肺
经血分〔海〕本草不言栀
子能吐仲景用为吐药栀子本非吐药为邪气在上拒而不纳食今上吐则邪因以出所谓其高者因而越之也或用为利小便药实
非利小便乃清肺也肺清则化行而膀胱津液之腑得此气化而出也本草言治大小肠热乃辛与庚合又与丙合又能泄戊先入中
州故也仲景治烦躁用栀子豉汤烦者气也躁者血也气主肺躁主血故用栀子以治肺烦香豉以治肾躁仲景以栀子色赤味苦入
心而治烦香豉色黑味咸入肾而治躁〔寇〕仲景治伤寒发汗吐下后虚寒不得眠若剧者必反复颠倒心中懊 栀子豉汤
治之因
其虚故不用大黄有寒毒故也栀子虽寒而无毒治胃中热气既亡血亡津液腑藏无润养内生虚热非此物不可去也又治心经留
热小便赤涩用去皮栀子火煨大黄连翘炙甘草等分末之水煎三钱服无不利也凡使须要如雀脑并须长有九路赤色者为上去
心胸中热用仁去肌表热用皮治上焦中焦连壳用下焦去壳治血病炒黑用
石膏 气寒味甘辛无毒入手太阴经少阳经足阳明经〔洁〕石膏性寒味辛而淡气味俱薄体重而沉降也阴
也乃
阳明经大
寒之药善治本经头痛牙痛止消渴中暑潮热然能寒胃令人不食非腹有极热者不宜轻用又阳明经中热发热恶寒燥热日晡潮
湿肌肉壮热小便浊赤大渴引饮自汗苦头痛之药仲景用白虎汤是也若无以上诸证勿服之多有血虚发热象白虎证及脾胃虚
劳形体病证初得之时与此证同医者不识而误用之不可胜救也〔垣〕石膏足阳明经也故仲景治伤寒阳明证身热目痛
鼻干不
得卧身以前胃之经也胸前肺之室也邪在阳明肺受火制故用辛寒以清肺气所以有白虎之名又治三焦皮肤大热入手少阳也
凡病脉数不退者宜用之胃弱者不可用按温热病烦热而渴脉洪大而数且长者非用石膏不能取效冬月有此脉证亦宜用之仲
景制白虎汤为正伤寒设也东垣处暑以后勿用之说不可拘泥此即市所谓寒水石者也亦谓之硬石膏细理白泽者良碎之如粟
米大先煮数十沸乃入余药以其气味难出故也
知母 气寒味苦气味俱浓沉而降阴也阴中微阳肾经本药入足阳明手太阴经气分〔垣〕其用有四泻无根
之肾
火疗有汗
之骨蒸止虚劳之热滋化原之阴仲景用此入白虎汤治不得眠者烦躁也烦出于肺躁出于肾君以石膏佐以知母之苦寒以清肾
之源缓以甘草粳米使不速下也又凡病小便 塞而渴者热在上焦气分肺中伏热不能生水膀胱绝其化源宜用气薄味薄淡渗
之药以泻肺火清肺金而滋水之化源若热在下焦血分而不渴者乃真水不足膀胱干涸乃无阴则阳无以化法当用黄柏知母大
苦寒之药以补肾与膀胱使阴气行而阳自化小便自通凡用拣肥润里白者去毛切引经上行则用酒浸焙干下行则用盐水润焙
(忌铁)
秦皮 气寒味苦无毒沉也降也〔海〕主热利下重下焦虚经云以苦坚之故用白头翁黄柏秦皮若苦之剂也
治风寒湿痹目
中青翳白膜男子少精妇人带下小儿惊痫宜作汤洗目俗呼为白 木取皮渍水浸出青蓝色与紫草同用以增光晕尤佳大戟为
之使恶吴茱萸〔珍〕 皮色青气寒味苦性涩乃是厥阴肝少阳胆经药也故治目病惊痫取其平木也治下利崩带取其收
涩也又
能治男子少精益精有子皆取其涩而补也故老子云天道贵涩此药乃服食及惊痫崩利所宜而人止知其治目一节几于废弃良
为可惋
白头翁 气寒味苦辛无毒瓦斯浓味薄可升可降阴中阳也主温疟狂易寒热 瘕积聚逐血止痛张仲景治热利下重用
白头
翁汤主之盖肾欲坚急食苦以坚之利则下焦虚故以纯苦之剂坚之男子阴疝偏坠小儿头秃膻腥鼻衄无此不效毒痢有此获功
亦多〔吴〕热毒下利紫血鲜血者宜之
大黄 气寒味苦无毒瓦斯味俱浓沉而降阴也用之须酒浸煨熟者寒因热用酒浸入太阳经酒洗入阳明经余经不用酒
〔垣〕
大黄苦峻下走用之于下必生用若邪气在上非酒不至必用酒浸引上至高之分驱热而下如物在高巅必射以取之也若用生者
则遗至高之邪热是以愈后或目赤或喉痹或头肿或膈上热疾生也〔寇〕仲景治心气不足吐血衄血泻心汤用大黄黄芩
黄连或曰
心气既不足而不用补心汤更用泻心何也答曰若心气独不足则当不吐衄也此乃邪热因不足而客之故令吐衄以苦补其心盖
一举而两得之有是证者用之无不效惟在量其虚实而已〔丹〕大黄苦寒善泄仲景用之泻心汤者正因少阴经不足本经
之阳亢
甚无辅以致阴血妄行飞越故用大黄泻去亢甚之火使之平和则血归经而自安夫心之阴气不足非一日矣肺与肝俱各受火而
病作故黄芩救肺黄连救肝肺者阴之主肝者心之母血之舍也肝肺之火既退则阴血复其旧矣寇氏不明说而云邪热客之何以
开悟后人也〔珍〕大黄乃足太阴手足阳明手足厥阴五经血分之药凡病在五经血分者宜用之若在气分用之是谓诛伐
无过矣
泻心汤治心气不足吐血衄血者乃真心之气不足而手厥阴心包络足厥阴肝足太阴脾足阳明胃之邪火有余也虽曰泻心实泻
四经血中之伏火也又仲景治心下痞满按之软者用大黄黄连泻心汤主之此亦泻脾胃之湿热非泻心也病发于阴而反下之则
作痞满乃寒伤荣血邪气乘虚结于上焦胃之上脘在于心故曰泻心实泻脾也素问云太阴所至为痞满又云浊气在上则生 胀
是矣病发于阳而反下之则成结胸乃热邪陷入血分亦在上脘分野仲景大陷胸汤丸皆用大黄亦泻脾胃血分之邪而降其浊气
也若结胸在气分则只用小陷胸汤痞满在气分则用半夏泻心汤矣成成氏注伤寒论亦不知分别此义〔颂〕本草称大黄
推陈致
新其效最神故古方下积滞多用之张仲景治伤寒用处尤多古人用毒药攻病必随人之虚实寒热而处治非一切轻用也梁武帝
因发热欲服大黄姚僧坦曰大黄乃是快药至尊年高不可轻用帝弗从几至委顿梁元帝常有心腹疾诸医咸谓宜用平药可渐宣
通僧坦曰脉洪而实此有宿积非用大黄无瘥理帝从之遂愈以此言之今医用一毒药而攻众病其偶中便谓此方神奇其差误则
不言用药之失可不戒哉去皮铡碎竹筛齐用
芒硝 气大寒味咸苦辛有小毒〔成〕内经云咸味下泄为阴又云咸以软之热淫于内治以咸寒气坚者以咸
软之热盛者以
寒消之故张仲景大陷胸汤大承气汤调胃承气汤皆用芒硝以软坚去实热结不至坚者不可用也〔海〕本草云朴硝味辛
是
辛以
润肾燥也今人不用辛字只用咸字咸能软坚也其义皆是本草言芒硝利小便而堕胎然伤寒妊娠可下者用此兼大黄引之直入
大腹润燥软坚泻热而母子俱安经云有故无殒亦无殒也此之谓欤以在下言之则便溺俱阴以前后言之则前气后血以肾言之
总主大小便难溺涩秘结俱为水少火盛经云热淫于内治以咸寒佐之以苦故用芒硝大黄相须为使也〔洁〕芒硝气薄味
浓沉而
降阴也其用有三去实热一也涤肠中宿垢二也破坚积热块三也〔珍〕朴硝是初得一煎而成者故力紧急而不和止可施
于粗犷
之人及敷涂之剂而已芒硝是朴硝淋过炼成故其性和缓仲景治伤寒多用之以此故也硝禀太阴之精水之子也气寒味咸走血
而润下荡涤三焦肠胃实热阳强之病乃折治火邪药也生用
香豉 气寒味苦无毒阴中之阴也主伤寒头痛烦躁满闷生用〔珍〕黑豆性平作豉则温既经蒸窨故能升能散
得葱则发汗得盐则能吐得酒则治风得薤则治痢得蒜则止血炒熟则大能止汗亦麻黄根节之义也
茵陈蒿 气微寒味苦辛无毒阴中微阳入足太阳经除烦热主风湿寒热邪气热结黄胆通身发黄小便不利〔寇〕
张仲景治伤寒热甚发黄身面悉黄者用之极效一僧因伤寒后发汗不彻有留热面身皆黄多热期年不愈医作
食治不对而食不减予与此药服五日病减三分之一十日减三分之二二十日病悉去方用山茵陈山栀子各三
分秦艽升麻各四钱为散每用三钱水四合煎二合去滓食后温服以知为度此药以山茵陈为本故书之
〔海〕仲景茵陈栀子大黄汤治湿热也栀子柏皮汤治燥热也如苗涝则湿黄旱则燥黄湿则泻之燥则润之可也
此二药治阳黄也韩祗和李思训治阴黄用茵陈附子汤大抵以茵陈为君主而佐以大黄附子各随其寒热也去
枝用叶手搓碎用
栝蒌实 气寒味甘微苦无毒〔丹〕栝楼实治胸痹者以其味甘性润甘能补肺润能降气胸中有痰
者乃肺受火逼失其降下之令今得甘缓润下之助则痰自降宜其为治嗽之要药也且又能洗涤胸膈中垢腻郁热
为治消渴之神药〔珍〕张仲景治胸痹痛引心背咳唾喘息及结胸满痛皆用栝蒌实乃取其甘寒不犯胃气能
降上焦之火使痰气下降也成无己不知此意乃云苦寒以泻热盖不尝其味原不苦而随文傅会尔肥大结实者
连子连皮细切用今人止用核仁非也
栝蒌根(一名天花粉) 气寒味甘微苦酸无毒主消渴身热烦满大热补虚安中通月水消肿毒瘀
血及热狂疮疖〔垣〕栝蒌根纯阴解烦渴行津液心中枯涸者非此不能除与辛酸同用导肿气
〔珍〕栝蒌根味甘微苦酸其茎叶味酸酸能生津感召之理故能止渴润枯微苦降火甘不伤胃昔人只言其苦寒
似未深察捣细罗过用
土瓜根 气寒味苦有小毒主疗诸邪气热结逐四时骨节中水疗天行热疾酒黄病壮热心烦闷热劳
能吐下人
连轺(连翘根也)气寒味甘苦有小毒主下热气益阴精故仲景治伤寒瘀热在里欲发黄用麻黄连
轺赤小豆汤
竹叶 气寒味甘无毒淡竹为上甘竹次之主胸中痰热咳逆上气〔寇〕诸笋性皆寒故知其叶
一致也张仲景竹叶汤惟用淡竹〔洁〕竹叶苦平阴中微阳〔垣〕竹叶辛苦寒可升可降阳中阴也
其用有二除新久风邪之烦热止喘促气胜之上冲
梓白皮 气寒味苦无毒主热毒去二虫时气温病头痛壮热初得一日用生梓木削去黑皮取里白
者切一升水二升五合煎汁每服八合取瘥折热之剂必以苦为主又曰大热之气寒以取之是也
(Those with strong flavors belong to Yin within Yin. Strong flavors have a purgative/descending effect. Sour, bitter, and salty flavors with cold qi belong to this category.)
*Scutellariae Radix* (Huanglian, 黄连): Cold in nature, bitter in taste, non-toxic. Its medicinal force and flavor are both strong; it can ascend and descend, belonging to Yang within Yin. It enters the Hand-Shaoyin Heart Meridian. Its functions include six aspects: first, clearing Heart Fire; second, removing damp-heat from the Middle Jiao; third, essential for treating various sores; fourth, dispelling wind-dampness; fifth, treating sudden onset of red eyes; sixth, stopping bleeding in the middle region. Zhang Zhongjing uses it in all five varieties of Xixin Decoction (Cordis Dispersing Decoction) for treating nine types of epigastric fullness. Li Dongyuan states: *Scutellariae Radix* enters the Foot-Shaoyin Kidney Meridian; due to its bitter dryness, it enters Heart Fire to address dryness. However, "clearing the Heart" actually clears Spleen Fire. According to Five Elements theory, "the child can make the mother full"; when excess occurs, drain the child. In treating blood disorders, Saposhnikoviae Radix (Fangfeng, 防风) acts as the ascending guide, *Scutellariae Radix* as the middle guide, and Sanguisorbae Radix (Diyu, 地榆) as the descending guide. Remove roots and fine-cut for use.
*Scutellariae Radix* (Huangqin, 黄芩): Cold in nature, bitter in taste, non-toxic. It can ascend and descend, belongs to Yin, specifically slight Yang within Yin. Enters the Blood aspect of the Hand-Taiyang Small Intestine Meridian. Li Guo states: Its qi is cool, taste bitter-sweet, qi is strong while flavor is thin, floating and ascending, belonging to Yin within Yang. Enters the Hand-Shaoyang Gallbladder and Hand-Yangming Large Intestine Meridians. Wine-fried to direct action upward. Li Dongyuan further notes: The hollow and light variety clears Lung Fire, benefits Qi, resolves phlegm, dispels wind-heat, and eliminates heat in the muscle layer. The solid and heavy variety clears Large Intestine Fire, nourishes Yin, reduces Yang, supplements Bladder cold water, and nourishes the source of transformation. This parallels the usage of Atractylodis Fructus (Zhishi, 枳实) and Aurantii Fructus (Zhiqiao, 枳壳). Li Guo summarizes nine uses: first, clearing Lung heat; second, resolving wind-heat and wind-dampness in the Upper Jiao skin; third, clearing various heat pathogens; fourth, benefiting Qi in the chest; fifth, eliminating phlegm in the diaphragm; sixth, removing dampness in the Spleen meridian; seventh, essential for summer use; eighth, nourishing Yin and reducing Yang postpartum; ninth, calming the fetus. Wine-fried to ascend, treating upper accumulation of blood. For dysentery with pus and blood, abdominal pain, tenesmus, and persistent fever, combine with Paeoniae Radix Alba (Baishao, 白芍) and Glycyrrhizae Radix (Gancao, 甘草). For painful sores, use bitter-cold herbs like *Scutellariae Radix*, distinguishing upper/lower regions and using guiding herbs. Su Song records: Zhang Zhongjing uses *Scutellariae Radix* in all four Xixin Decoctions for epigastric fullness because it treats various heats and benefits the Small Intestine. Ge Gen Huang Qin Huang Lian Tang (Kudzu, Scutellaria, and Coptis Decoction) is used for diarrhea, wheezing, and sweating after incorrect purgation in Taiyang disease. Sanmu An Tai San (Sanmu Calming Fetus Powder) also frequently uses it. Li Shizhen records: Li Guojie states *Scutellariae Radix* clears Lung Fire and treats Spleen dampness; Dongyuan states Pian Qin (slice form) treats Lung Fire, Tiao Qin (strip form) treats Large Intestine Fire; Danxi states it treats Upper and Middle Jiao fire. Zhang Zhongjing uses it in Xiao Chaihu Tang (Minor Bupleurum Decoction) for Shaoyang syndrome, Huang Qin Tang for Taiyang-Shaoyang combined disease with diarrhea, and Xixin Decoction for post-purgation epigastric fullness without pain. Cheng Wuji states *Scutellariae Radix* enters the Heart via bitterness to clear fullness heat, indicating it enters the Hand-Shaoyin, Hand-Yangming, Foot-Taiyin, and Foot-Shaoyang meridians. Generally, its cold nature and bitter taste enter the Heart to clear heat and treat Spleen damp-heat. This prevents Metal from being controlled by Fire and stops Stomach Fire from entering the Lung, thereby saving the Lung. It is unsuitable for Lung deficiency as bitter-cold damages the Spleen and Stomach (the Mother organ). Shaoyang syndrome presents with alternating chills and fever, hypochondriac fullness, silent desire not to eat, irritability, or vomiting. Although located half-exterior half-interior, hypochondriac fullness involves Upper Jiao pathogens of Heart and Lung, while irritability and aversion to food involve Middle Jiao Spleen and Stomach. Thus, *Scutellariae Radix* treats the Ministerial Fire of Shaoyang. Cheng Wuji’s commentary only mentions dispersing transmitted heat, missing the subtlety of treating Fire. Yang Shiying claims Bupleuri Radix (Chaihu, 柴胡) is inferior to *Scutellariae Radix* for reducing fever, not realizing Chaihu disperses the branch of fire, while *Scutellariae Radix* conquers heat to break the root. Zhang Zhongjing advises removing *Scutellariae Radix* for abdominal pain or adding Fu Ling (Poria) for palpitations and difficult urination, seemingly contradicting *Ben Cao* statements on treating lower abdominal cramps. Cheng Shi attributes this to *Scutellariae Radix* hardening the Kidney via bitterness, but this is likely incorrect. One must differentiate via pulse and symptoms: if caused by cold/drink with non-rapid pulse, avoid it; if caused by heat-jue or Lung heat, use it. Skilled readers seek principles rather than literal text. Remove skin and black rot, fine-cut, and sieve.
*Coptidis Rhizoma* (Huangbai, 黄柏): Cold in nature, bitter in taste, non-toxic. Strong medicinal force and flavor, sinking and descending, belonging to Yin, slightly pungent among Yin, thus Yang within Yin. Enters the Foot-Shaoyin Kidney Meridian, serving as a guiding herb for the Foot-Taiyang Bladder Meridian. Li Dongyuan states: Treats Wei syndrome, Jue syndrome, and weak knees/legs due to Kidney Water and Bladder insufficiency. Add small amounts to Huang Bai Tang to restore strength. Honey-fried powder treats mouth ulcers miraculously and is essential for paralysis. It clears Bladder heat, benefits the lower orifice, clears Bladder meridian fire, and supplements Kidney insufficiency. *Neijing* states: "Bitterness hardens." The Kidney dislikes dryness and retains dampness. Zhi Zi (Gardeniae Fructus) and Huang Qin enter the Lung, Huang Lian enters the Heart, Huang Bai enters the Kidney; each addresses dryness according to its affinity. Huoren Shu’s Jiedu Tang treats internally and externally. Use raw for descending real fire; wine-processed for upper body; salt-processed for lower body; honey-processed for middle body without damaging Stomach.
*Gardeniae Fructus* (Zhizi, 栀子): Cold in nature, bitter in taste, non-toxic. Li Guo states: Thin qi, strong flavor, light and clear ascending, floating qi, descending flavor, Yang within Yin. Li Dongyuan states: Sinking, Yin. Enters the Blood aspect of the Hand-Taiyin Lung Meridian. Li Shizhen notes: *Ben Cao* does not mention emetic properties, but Zhang Zhongjing used it as an emetic. It is not inherently emetic; rather, pathogenic factors in the upper region reject food, causing vomiting to expel pathogens ("The high ones, cause them to vomit"). Some use it to promote urination, but it actually clears the Lung. Clearing the Lung allows Qi transformation, enabling the Bladder to excrete fluids. *Ben Cao* mentions treating Large and Small Intestine heat due to elemental combinations. Zhang Zhongjing uses Zhizi Chi Tang (Gardenia and Fermented Soybean Decoction) for irritability (Qi/Lung) and restlessness (Blood/Kidney). Red color/bitter taste enters Heart for irritability; black color/salty taste enters Kidney for restlessness. Kou Zongshi records: Used after sweating/vomiting/purging for insomnia and mental agitation due to deficiency, avoiding Da Huang (Rhei Radix et Rhizoma) due to its cold toxicity. Zhizi treats internal empty heat from fluid/blood loss. For Heart heat and dark urine, combine with processed Da Huang, Forsythiae Fructus (Lianqiao, 连翘), and roasted Glycyrrhizae Radix. Select grains resembling quail brains with nine ridges and red color. Kernel for chest heat; peel for surface heat; whole shell for Upper/Middle Jiao; peeled for Lower Jiao; charred for blood disorders.
*Gypsum Fibrosum* (Shigao, 石膏): Cold in nature, sweet-pungent, non-toxic. Enters Hand-Taiyin Lung, Shaoyang, and Foot-Yangming Stomach meridians. Li Guo states: Cold, pungent-bland, thin qi/flavor, heavy and sinking, Yin. Major cold herb for Yangming Meridian. Treats headache, toothache, thirst, heatstroke, and tidal fever. However, it may chill the Stomach and suppress appetite; avoid unless extreme heat exists. Also treats Yangming heat, fever with aversion to cold, dryness, afternoon tidal fever, muscle fever, turbid urine, intense thirst, spontaneous sweating, and severe headache. Baihu Tang (White Tiger Decoction) addresses this. Avoid if these signs are absent; misdiagnosis of blood-deficiency fever or Spleen-Stomach deficiency can be fatal. Li Dongyuan adds: It clears Lung heat constrained by Yangming fire. For rapid pulse, use it; avoid in weak Stomach. Effective for warm diseases with thirst and surging pulse, even in winter. Do not strictly follow Dongyuan’s advice to avoid it after End of Heat. It is also known as Hanshui Shi (Cold Water Stone) or Ying Shigao (Hard Gypsum). Fine white texture is best. Crush to millet size, boil first before adding other herbs.
*Anemarrhenae Rhizoma* (Zhimu, 知母): Cold in nature, bitter in taste, strong qi/flavor, sinking, Yin, slight Yang within Yin. Primary herb for Kidney Meridian, entering Foot-Yangming and Hand-Taiyin Qi aspects. Li Dongyuan states: Four uses: clearing rootless Kidney fire, treating bone-steaming with sweat, stopping deficiency heat, and nourishing the source of Yin. Zhang Zhongjing combines it with Shigao in Baihu Tang for restlessness. Fang Feng guides up, Zhimu clears Kidney source, Gancao and Jing Mi (Coix Seed) slow descent. For urinary obstruction with thirst (Upper Jiao heat blocking Water generation), use bland-draining herbs to clear Lung fire. For urinary obstruction without thirst (Lower Jiao blood heat/Yin deficiency), use Huangbai and Zhimu to tonify Kidney/Bladder, allowing Yang to transform and urine to flow. Select plump, white interior, remove hairs. Wine-processed for ascending; salt-water processed for descending. (Avoid iron).
*Fraxini Cortex* (Qinpi, 秦皮): Cold in nature, bitter in taste, non-toxic, sinking. Treats heat-dysentery with heaviness and lower Jiao deficiency. *Neijing* states "bitterness hardens," hence used with Weitou Wang and Huangbai. Treats wind-cold-damp bi, eye opacities, male infertility, female leukorrhea, and pediatric convulsions. Wash eyes with decoction. Extract blue-green juice, mix with Lithospermi Radix (Zicao, 紫草) for better effect. Guided by Euphorbiae Humifusa Herba (Daji, 大戟); incompatible with Evodiae Fructus (Wuzhuyu, 吴茱萸). Li Shizhen adds: Green color, cold/bitter/astringent nature targets Liver/Gallbladder meridians. Treats eye disorders and convulsions by pacifying Wood; treats dysentery and leukorrhea by astringency; treats infertility by astringent tonification. Often overlooked except for eye treatments.
*Pulsatillae Radix* (Baitouweng, 白头翁): Cold in nature, bitter-pungent, non-toxic, thick qi/thin flavor, ascending/descending, Yang within Yin. Treats warm malaria, mania, cold-heat alternations, masses, blood stasis, and pain. Zhang Zhongjing uses Baitouweng Tang for heat-dysentery with urgency. Hardens lower Jiao via bitter taste. Treats hernia, alopecia, fetid discharge, and epistaxis. Effective for toxic dysentery. Wu Qian states: Suitable for heat-toxin dysentery with purple/fresh blood.
*Rhei Radix et Rhizoma* (Dahuang, 大黄): Cold in nature, bitter in taste, non-toxic, strong qi/flavor, sinking, Yin. Use wine-soaked/roasted for "cold treated with heat." Wine directs to Taiyang; washing directs to Yangming. Li Dongyuan states: Bitter and峻 (severe) downward movement. Raw for lower body; wine-processed for upper body to drive heat down ("shooting at high targets"). Raw use leaves upper heat, causing post-recovery eye/throat/head issues. Kou Zongshi records: Zhang Zhongjing uses Dahuang in Xixin Decoction for hematemesis/epistaxis due to deficient Heart Qi invaded by heat. Bitterness tonifies Heart by clearing pathogenic heat. Zhu Danxi states: Dahuang clears excessive Yang fire causing blood rebellion. Huang Qin saves Lung, Huang Lian saves Liver. Li Shizhen states: Dahuang enters Blood aspect of Taiyin, Yangming, and Jueyin meridians. Use for blood disorders; avoid for Qi disorders. Xixin Decoction treats excess fire in Pericardium, Liver, Spleen, and Stomach. Epigastric fullness after incorrect purgation involves Cold injuring Nutritive Blood and pathogenic factors in Upper Jiao; "clearing Heart" actually clears Spleen. Chest binding involves Heat entering Blood aspect. Dahuang descends turbid Qi. Su Song records: Dahuang pushes out old and generates new. Ancient physicians used toxic herbs cautiously based on deficiency/excess. Yaoengt Tan advised against Dahuang for Emperor Wu of Liang due to age, but he refused and nearly died. For Emperor Yuan of Liang, Yaoingt Tan correctly diagnosed stagnation requiring Dahuang. Physicians should beware of indiscriminate use. Remove skin, cut, sieve.
*Natrii Sulfas* (Mangxiao, 芒硝): Very cold, salty-bitter-pungent, slightly toxic. *Neijing*: Salty drains downward and softens hardness. Cold dissipates heat. Zhang Zhongjing uses it in Daxiexiong Tang, Dachengqi Tang, and Tiaoweichengqi Tang to soften hardness and clear heat. Not for non-hard accumulations. Li Shizhen notes: Puxiao (Mirabilite) has pungent property to moisten Kidney dryness; modern texts emphasize salty property to soften. Safe in pregnancy with Dahuang for heat constipation ("If there is pathology, no harm"). Promotes urination and bowel movements. Li Guo states: Three uses: clearing real heat, cleansing intestinal residue, breaking hard heat masses. Li Shizhen distinguishes Puxiao (initial extraction, harsh) from Mangxiao (refined, mild). Mangxiao derives from Taiyin essence, enters Blood, moistens downward, clears Sanjiao/Stomach-Intestine real heat, and treats Yang-excess fire. Use raw.
*Dietary Fermented Soybean* (Xiangchi, 香豉): Cold in nature, bitter in taste, non-toxic, Yin within Yin. Treats cold damage headache, irritability, and oppression. Use raw. Li Shizhen notes: Black beans are neutral; fermentation makes them warm, capable of ascending and dispersing. Combined with Congei Caulis (scallion) induces sweating; with Sal (salt) induces vomiting; with Alcohol treats wind; with Allii Macrostemonis Bulbus (leek) treats dysentery; with Allii Sativi Bulbus (garlic) stops bleeding; cooked stops sweating.
*Artemisiae Scopariae Herba* (Yinchen Hao, 茵陈蒿): Slightly cold, bitter-pungent, non-toxic, slight Yang within Yin. Enters Foot-Taiyang Meridian. Clears irritability, treats wind-cold-damp-heat, heat-binding jaundice, generalized yellowing, and difficult urination. Kou Zongshi records: Effective for severe jaundice. Case study: Monk with lingering heat jaundice cured over 20 days using Yinchen, Zhizi, Qin Jiao, and Shengma. Li Shizhen notes: Yinchen Hao Tang treats damp-heat; Zhizi Baipi Tang treats dry-heat. Differentiate wet vs. dry jaundice. Han Zhihe and Li Sixun use Yinchen Fuzi Tang for cold jaundice. Remove stems, use leaves, crush by hand.
*Trichosanthis Fructus* (Gualou Shi, 栝蒌实): Cold in nature, sweet-mildly bitter, non-toxic. Zhu Danxi states: Sweet and moistening, tonifies Lung, directs Qi downward. Resolves phlegm in chest caused by Fire constraining Lung. Cleanses chest heat, treating thirst. Li Shizhen records: Zhang Zhongjing uses it for chest bi pain, coughing saliva, asthma, and chest binding. Its sweet-cold nature does not damage Stomach Qi, directs upper heat down, and moves phlegm. Cheng Wuji mistakenly called it bitter-cold. Use large, firm fruits with seed and skin, finely cut. Using only kernel is incorrect.
*Trichosanthis Radix* (Tianhuafen, 栝蒌根): Cold in nature, sweet-mildly bitter-sour, non-toxic. Treats thirst, fever, irritability, emptiness, regulates menstruation, reduces swelling, detoxifies, treats blood stasis, mania, and sores. Li Dongyuan states: Pure Yin, relieves thirst, moves fluids. Essential for dry heart. Combine with pungent-sour to guide swelling. Li Shizhen adds: Sour generates fluids; mild bitter clears heat; sweet does not damage Stomach. Past texts focusing only on bitter-cold missed this. Sift finely.
*Polypodi Rhizoma* (Tugua Gen, 土瓜根): Cold in nature, bitter, slightly toxic. Treats various pathogens, heat binding, water retention in joints, epidemic fevers, alcohol jaundice, fever, irritability, and consumption. Can induce vomiting or purging.
*Forsythiae Radix* (Lianyao, 连轺): Cold in nature, sweet-bitter, slightly toxic. Descends heat, benefits Yin essence. Zhang Zhongjing uses Ma Huang Lian Qiao Chi Dou Tang for heat-toxin jaundice.
*Bambusae Folium* (Zhuye, 竹叶): Cold in nature, sweet, non-toxic. Light bamboo is superior. Treats chest phlegm-heat, cough, and rebellious Qi. Kou Zongshi notes: Bamboo shoots are cold, so leaves are too. Zhang Zhongjing’s Zhuye Tang uses light bamboo. Li Guo states: Bitter-flat, slight Yang within Yin. Li Dongyuan states: Pungent-bitter-cold, ascending/descending, Yin within Yang. Two uses: clears new/old wind-heat irritability; stops wheezing and rebellious Qi.
*Broussonetiae Cortex* (Zibai Pi, 梓白皮): Cold in nature, bitter, non-toxic. Treats heat-toxin, parasites, seasonal warm diseases, headache, and fever. Use fresh inner bark boiled. Bitter is primary for clearing heat; cold nature conquers heat.