此剂以同气之阴相易。引之使邪原从阴窍而出。以交媾遗泄，热邪必从阴户受之，谚所谓来处来，
去处去是也。他如生地、麦冬、知母、黄柏、犀角、黄连、滑石皆可采用。〔加柴胡，亦可用。〕
普济消毒饮〔重订〕泰和二年四月，民多疫疠，初觉憎寒，壮热体重，次传头面肿盛，目不
能闭，上喘咽喉不利，舌干口燥，俗云大头伤寒诸风药不愈。东垣曰∶身半以
上，天之气也，邪热客于心肺之间，上攻头目，而为肿耳。此方治之，活者甚众。
连翘 黄连 黄芩〔泻心肺之火。〕 玄参〔治无根之火，〕 青黛〔散郁火，止热
烦。〕 薄荷 荆芥〔散风热，清头目。〕 牛蒡〔散风热，消浮肿。〕 甘菊〔治头目肿痛。〕
甘草 桔梗〔为舟楫之剂，恐其速下也。〕 柴胡〔为升提之药，欲其达上也。〕 橘红〔利
气以开壅。〕 人参〔扶正以驱邪，不虚勿加。〕便秘加酒炒大黄。〔从其实而泻，釜底抽薪之
法也。共为细末，半用汤调，时时呷之。病在上者，服药不厌少而频也，半用蜜丸，噙化就卧，令药
性上行也。〕
此方总以散邪退热消毒为主。大抵治法不宜峻攻，攻则邪气不去，反伤其正。若大便热结，方可
用酒浸大黄，或玄明粉，微下通之。若人虚脉弱者，方可认加人参三、五分。此症若先发于鼻额，面
目红肿者，是属阳明，渴者加石膏。若发于耳目之前后上下，头角红肿者，乃属少阳，倍加柴胡、花
粉。若发于头顶，连于巅顶者，乃属太阳，加羌活。若三阳受邪，合并头面前后耳鼻，头大如瓮者，加
羌、葛，倍柴胡治之。外用清凉救苦散敷之。
清凉救苦散〔重订〕 黄连、黄柏、大黄、芒硝、雄黄、青黛〔等分，为末。〕 芭蕉
根〔捣汁〕同蜜调敷肿处。
阳症见阳脉为顺，若见阴脉为逆。〔以其气血精津，未病先亏故也。有素禀阴脉者宜审。〕汗后
身凉，脉静则吉，汗下后复大热，脉躁乱者，〔邪气太盛，不为药衰。〕不治，加喘急必死。发热脉躁
急，〔真阴竭而邪独胜也。〕狂言〔肾绝也。〕不能食，〔胃绝也。〕见此三者，病虽小愈
必死。脉阴阳俱虚，热不止者〔正虚邪盛也。〕死。热病
七、八日，脉微小，〔正气虚也。〕溲血口中干者〔真阴伤也。〕死。病温虚甚者〔以本元虚而不
能御邪也。〕死。热病不知所痛，〔有痛而不得其所在。〕耳聋口干不能自收，〔体重不能收持。〕
阳〔阳胜之时。〕热甚，阴〔阴胜之时。〕颇有寒者，热在髓，死不治。热而痉者死。〔肢体抽搐，
腰脊反强，切牙切齿，皆痉之症，热极大伤阴血而然。〕热病目不明，〔脏腑之精气已竭也。〕热不
已者死。热病舌本烂，〔脾肾脉皆系舌本，二脏之阴俱绝。〕热不已者死。谵语舌强舌硬舌黑
者〔热甚津竭也。〕死。阳症谵语，身当有热，脉当洪大，而反手足逆冷，脉沉细而微者〔邪气盛而
正气败也。〕死。直视〔则肾水垂绝。〕谵语〔为心热神昏。〕喘满者〔气从上脱也。〕死。下
利者〔气从下脱也。〕亦死。直视摇头，体如烟熏，心绝死。直视狂言，遗尿不知，肾绝死。环口
黧黑，冷汗发黄，脾绝死。汗出发润，喘而不休，肺绝死。唇吻反青，手足振动，肝绝死。结胸症
具，烦躁者死。〔误下津竭，孤阳无附而欲脱也。〕吐则烦躁，〔上下交征，中气立断。〕四肢逆冷
者〔脾胃气绝也。〕死。下利发热，厥逆躁不得卧者〔阴阳两绝也。〕死。下利发热，〔阴从下脱，
阳从外越。〕汗出不止者〔汗多亡阳故也。〕死。下利厥逆不能食，忽反能食，〔是胃阳发露，灯尽
复明之兆。〕此名除中死。〔言胃中阳气消除尽也，亦有属胃气来复者。当合形气断之耳。〕下利
恶寒，身蜷手足逆冷者〔阴盛无阳也。〕死。〔热病中或过用寒凉，间亦有之。〕泄而腹满甚者〔脾
气败也。〕死。下利止而头眩；时时自冒者死，〔此阴尽利止，孤阳无附而上越也。〕冷汗如油，贯
珠不流者〔绝汗出也。〕死。循衣摸床，两手
撮空者死。〔亦有因热神昏，当参脉症救之。〕目乱无神气，目无精光者死。〔失神者亡也。〕张口
如鱼，出气不返者〔肾绝不能纳气归原也，〕死。口臭不可近者〔内热极而脏腑伤也。〕死。舌上赤紫
干光者〔心火自焚也。〕死。舌卷囊缩者〔厥阴气绝也。〕死。皮肤枯燥，大肉脱者〔太阴气绝也。〕
死。
This formula utilizes the principle of "same qi attracting same qi," using Yin to counteract Yin, guiding the pathogenic factor to exit through the yin orifices from which it originally entered. Since during sexual intercourse and seminal emission, heat pathogens must enter via the yin aperture, as the proverb says: "From where it comes, there let it go." Other herbs such as Shengdi Huang (Rehmanniae Radix), Maidong (Ophiopogonis Radix), Zhimu (Anemarrhenae Rhizoma), Huangbai (Phellodendri Cortex), Xijiao (Rhinocerotis Cornu), Huanglian (Coptidis Rhizoma), Huashi (Talcum) can also be adopted. [Chai Hu (Bupleuri Radix) may also be added.]
Puji Xiaodu Yin (Revised Edition): In the fourth month of Taihe Year 2, many people suffered from epidemics. Initially, they felt aversion to cold, high fever, and heaviness of the body. Subsequently, severe swelling occurred on the head and face, eyes could not be opened, upper asthma and throat obstruction developed, with a dry tongue and mouth. Commonly known as "Big Head Cold," various wind-dispelling drugs were ineffective. Li Dongyuan stated: "The upper half of the body is governed by Heaven's Qi. When pathogenic heat lodges between the Heart and Lungs, it attacks upward to the head and eyes, causing swelling." This formula treats this condition, saving many lives.
Lian Qiao (Forsythiae Fructus), Huang Lian (Coptidis Rhizoma), Huang Qin (Scutellariae Radix) [clears and purges Heart and Lung fire], Xuan Shen (Scrophulariae Radix) [treats rootless fire], Qing Dai (Indici Folium) [disperses stagnant fire, stops heat-induced irritability], Bo He (Menthae Haplocalycis Herba), Jing Jie (Schizonepetae Spica) [disperses wind-heat, clears head and eyes], Niu Bang Zi (Arctii Fructus) [disperses wind-heat, reduces edema], Gan Ju (Chrysanthemi Flos) [treats head and eye pain/swelling], Gan Cao (Glycyrrhizae Radix et Rhizoma), Jie Geng (Platycodonis Radix) [acts as a carrier agent to prevent rapid downward action], Chai Hu (Bupleuri Radix) [as an ascending drug, aiming to reach the upper part], Ju Hong (Citri Reticulatae Pericarpium) [regulates Qi to open congestion], Ren Shen (Ginseng Radix et Rhizoma) [supports healthy Qi to expel pathogenic factors; do not add if there is no deficiency]. If constipation occurs, add Da Huang (Rhei Radix et Rhizoma) stir-fried with wine [drains according to excess, a method akin to removing firewood from under the cauldron]. Grind all into fine powder. Use half mixed with decoction, sipping frequently. For diseases located in the upper jiao, do not disdain small doses taken frequently. Use the other half to make honey pills, hold in the mouth to dissolve before lying down, allowing the medicinal properties to ascend.
This formula primarily focuses on dispersing pathogenic factors, reducing fever, and detoxifying. Generally, treatment methods should avoid harsh purgation; if forced, pathogenic factors will not be expelled, but rather healthy Qi will be damaged. If there is heat accumulation in the bowels, one may use Da Huang soaked in wine or Xuan Ming Fen (Mirabilite) for mild purgation. If the patient is weak with a faint pulse, consider adding Ren Shen (Ginseng Radix et Rhizoma) 3-5 fen. If this condition starts at the nose and forehead with redness and swelling of the face and eyes, it belongs to the Yangming channel; add Shi Gao (Gypsum Fibrosum) if thirsty. If it starts around the ears and eyes, front, back, top, and bottom, with redness and swelling of the temporal region, it belongs to the Shaoyang channel; double the dosage of Chai Hu (Bupleuri Radix) and Hua Fen (Trichosanthis Radix). If it starts on the crown, extending to the vertex, it belongs to the Taiyang channel; add Qiang Huo (Notopterygii Rhizoma et Radix). If all three Yang channels are affected, with combined swelling of the head, face, anterior and posterior ears/nose, and the head is large as a jar, add Qiang Huo (Notopterygii Rhizoma et Radix) and Ge Gen (Puerariae Lobatae Radix), and double Chai Hu (Bupleuri Radix) for treatment. Externally apply Qingliang Jiuku San (Cooling and Saving from Suffering Powder).
Qingliang Jiuku San (Revised Edition): Huang Lian (Coptidis Rhizoma), Huang Bai (Phellodendri Cortex), Da Huang (Rhei Radix et Rhizoma), Mang Xiao (Mirabilite), Xiong Huang (Realgar), Qing Dai (Indici Folium) [equal parts, ground into powder]. Ba Jiao Gen (Musa Basjoo Radix) [crushed for juice] mixed with honey, applied to the swollen area.
Yang syndromes presenting with Yang pulses are favorable (shun); presenting with Yin pulses is unfavorable (ni) [because Qi, Blood, Essence, and Fluids were deficient before illness onset. Those with innate Yin pulses should be examined carefully]. After sweating, if the body cools and the pulse becomes calm, it is auspicious. If after sweating or purging, high fever returns with a restless pulse [pathogenic factor is too strong, not subdued by medicine], it is incurable; if accompanied by asthma/shortness of breath, death is certain. Fever with a restless pulse [True Yin exhausted, pathogenic factor prevails], delirious speech [Kidney Qi exhausted], inability to eat [Stomach Qi exhausted], seeing these three signs means death even if symptoms temporarily subside. Pulses both Yin and Yang are deficient, fever does not stop [Healthy Qi deficient, Pathogenic factor excessive], death. Heat disease lasting seven or eight days, pulse minute/small [Healthy Qi deficient], blood in urine and dry mouth [True Yin injured], death. Severe deficiency in warm disease [Original Yuan Qi deficient, unable to resist pathogenic factors], death. Heat disease with unknown pain location [pain exists but location unclear], deafness, dry mouth, inability to self-control [body heavy, unable to support itself], when Yang wins heat is severe, when Yin wins cold is significant, heat in marrow, death, incurable. Heat disease with spasms [limb convulsions, opisthotonos, teeth grinding, all signs of spasm caused by extreme heat injuring Yin and Blood], death. Heat disease with blurred vision [Essence and Qi of Zang-Fu organs exhausted], fever not stopping, death. Heat disease with rotting tongue base [Spleen and Kidney meridians connect to the tongue base, Yin of both organs exhausted], fever not stopping, death. Delirium, stiff tongue, hard tongue, black tongue [Heat severe, fluids exhausted], death. Yang syndrome with delirium, body should be hot, pulse should be surging and large, but instead hands and feet are cold, pulse deep, thin, and faint [Pathogenic factor excessive, Healthy Qi defeated], death. Fixed gaze [Kidney Water about to exhaust], delirium [Heart heat causing spirit confusion], asthma and fullness [Qi escaping from above], death. Diarrhea [Qi escaping from below], also death. Fixed gaze with head shaking, body like smoked color, Heart exhaustion death. Fixed gaze with wild speech, enuresis unaware, Kidney exhaustion death. Black ring around mouth, cold sweat turning yellow, Spleen exhaustion death. Sweating with wet hair, continuous asthma, Lung exhaustion death. Lips and corners of mouth turning blue, hand and foot tremors, Liver exhaustion death. Chest binding symptoms complete, with irritability, death [Misguided purging exhausted fluids, solitary Yang has no attachment and desires to escape]. Vomiting then irritability [Upper and lower attacking each other, Middle Qi severed], cold hands and feet [Spleen and Stomach Qi exhausted], death. Diarrhea with fever, cold limbs, restlessness unable to lie down [Yin and Yang both exhausted], death. Diarrhea with fever, continuous sweating [Excessive sweating leads to loss of Yang], death. Diarrhea, cold limbs, inability to eat, suddenly able to eat again [This is the exposure of Stomach Yang, a sign of the lamp dying but flaring up again], named "Chu Zhong" (Elimination of Middle), death [Meaning Stomach Yang is completely eliminated; sometimes it belongs to recovery of Stomach Qi, judgment should be made based on form and Qi]. Diarrhea with aversion to cold, curled body, cold hands and feet [Yin excessive, no Yang], death [In heat diseases, overuse of cold/cool drugs may cause this occasionally]. Diarrhea with severe abdominal fullness [Spleen Qi failed], death. Diarrhea stops but dizziness occurs; frequent spontaneous vertigo, death [This is Yin exhausted, diarrhea stops, solitary Yang has no attachment and floats upward]. Cold sweat like oil, beads not flowing [Absolute sweat exiting], death. Grasping clothes, touching bed, hands picking at empty air, death [Sometimes due to heat causing spirit confusion, rescue should refer to pulse and symptoms]. Eyes chaotic without spirit, eyes lacking luster, death [Loss of spirit means death]. Mouth open like a fish, breath not returning [Kidney cannot grasp Qi and return it to origin], death. Bad breath that cannot be approached [Internal heat extreme, Zang-Fu organs injured], death. Tongue surface red-purple, dry and shiny [Heart Fire self-burning], death. Tongue curled and scrotum contracted [Jueyin Qi exhausted], death. Skin dry and rough, large muscles wasted away [Taiyin Qi exhausted], death.