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When the Liver is diseased, there is fullness in the hypochondriac regions extending to the lower abdomen, causing irritability. When deficient, vision becomes blurred, hearing diminishes, fear arises easily, and one feels as if being pursued. Treatment should select points on the Liver Meridian. If Qi rebels upward in the Jueyin and Shaoyang meridians causing headache, deafness, and poor hearing, bloodletting should be performed.

When the Heart is diseased, there is pain in the chest, distension and fullness in the hypochondria, pain under the ribs, pain in the chest, back, and between the scapulae, and pain in the medial aspect of the arm. When deficient, the chest and abdomen become distended, and pain is felt with traction between the hypochondria and the waist. Treatment should select points on the Heart Meridian. For cases involving sublingual blood vessels of the Shaoyin and Taiyang meridians, or complications from accidental vessel injury during needling, appropriate blood management is required.

When the Spleen is diseased, the body feels heavy, hunger is frequent but muscles are atrophic and weak, the feet are flaccid and difficult to lift for walking, and there is pain in the soles. When deficient, abdominal fullness, borborygmus, and undigested stool diarrhea occur. Treatment should select points on the Spleen Meridian; if abnormalities exist in the blood vessels of the Foot-Taiyang, Foot-Yangming, and Foot-Shaoyin meridians, corresponding treatment is applied.

When the Lungs are diseased, there is wheezing, coughing, rebellious Qi, shoulder and back pain, sweating, coldness in the sacral region, and pain in the inner thigh, knee, calf, and foot. When deficient, there is shortness of breath, inability to complete inhalation, deafness, and dry throat. Treatment should select points on the Lung Meridian, specifically targeting blood vessels located lateral to the Foot-Taiyang meridian and medial to the Foot-Jueyin meridian.

When the Kidneys are diseased, there is abdominal distension, swelling of the calves, wheezing, coughing, heaviness of the body, restless sleep, sweating with aversion to wind. When deficient, there is pain in the chest, distending pain in the greater and lesser abdomen, cold extremities (Jue), and mental depression. Treatment should select points on the Kidney Meridian; if abnormalities exist in the blood vessels of the Foot-Shaoyin and Foot-Taiyang meridians, corresponding treatment is applied.

If the Taiyang organ Qi is exclusively excessive, presenting with Jue-ni (rebellious Qi), wheezing, and upward rushing of deficient Qi, this indicates Yin deficiency and Yang excess. Both exterior and interior meridians should be reduced, using the Shu-Stream points of the lower limbs. If the Yangming organ Qi is exclusively excessive, indicating a concentration of Yang Qi internally, Yang should be reduced and Yin supplemented, using the Shu-Stream points of the lower limbs. If the Shaoyang organ Qi is exclusively excessive, indicating Jue Qi, sudden swelling occurs anterior to the Qiao vessels. The Shu-Stream points of the lower limbs should be selected. Exclusive excess in Shaoyang represents an overabundance of One-Yang. If the Taiyin organ Qi is combative (excessive pathogenic factor), careful examination of True Qi is needed; when Qi of the five pulses is scanty and Stomach Qi is unbalanced, it is a disease of the Three-Yin meridians, suitable for treating the lower Shu-Stream points. Use tonification of Yang and reduction of Yin. "One-Yang whistling alone" indicates Shaoyang Jue, where Yang Qi merges upward, causing tension in the four limbs and Qi filling the Kidneys. Treating the meridians with reduction of Yang and tonification of Yin is indicated. Arrival of One-Yin pertains to the treatment of Jueyin. For True Deficiency affecting the Heart, where Jue Qi lingers and combines, causing spontaneous sweating, diet and herbs should be regulated, and treatment focused on the lower Shu-Stream points.

When diseases affect the Five Zang organs, the Twelve Yuan-Source points should be selected. The Twelve Yuan-Source points are where the Qi of the Five Zang organs is endowed and where the Qi and flavor of the 365 acupoints converge. When the Five Zang organs are diseased, reactions manifest at the Twelve Yuan-Source points. Each Yuan-Source point has its specific origin. Knowing these origins and observing their reactions allows one to understand damage to the Five Zang organs. The Lesser Yin within Yang is the Lung, its Yuan-Source point is Taiyuan (LU9), bilateral. The Greater Yang within Yang is the Heart, its Yuan-Source point is Daling (PC7), bilateral. The Lesser Yang within Yin is the Liver, its Yuan-Source point is Taichong (LR3), bilateral. The Supreme Yin within Yin is the Spleen, its Yuan-Source point is Taibai (SP3), bilateral. The Greater Yin within Yin is the Kidney, its Yuan-Source point is Taixi (KI3), bilateral. The Yuan-Source of the Gao (Epigastrium) is Jiugwei (CV15), single. The Yuan-Source of the Mang (Blind area/Metabolism) is Bozhong (ST15/Shimen KI5 context dependent, here referred to as Bó Yīng), single. These Twelve Yuan-Source points govern diseases of the Five Zang and Six Fu organs.